Results 61 to 70 of about 8,021,995 (282)
JAMA, 2019 Metformin is the first-line pharmacologic treatment for type 2 diabetes and the most commonly prescribed drug for this condition worldwide, either alone or in combination with insulin or other glucose-lowering therapies. Metformin is a biguanide, a drug class of herbal origin that has been widely used to treat diabetes since the 1950s.1,2 Two other ...
James, Flory, Kasia, Lipska
openaire +3 more sources
Molecular Oncology, EarlyView.LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David +12 more
wiley +1 more source
Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy
Molecular Oncology, EarlyView.We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley +1 more source
Jurnal Maksipreneur: Manajemen, Koperasi, dan Entrepreneurship, 2019 Edisi kali ini diawali oleh penelitian Krisnawati, Santoso, dan Sutarmin yang mengungkap potensi kekayaan alam perdesaan untuk menciptakan kemandirian ekonomi Desa Sunyalangu Kabupaten Banyumas melalui aplikasi konsep satu desa satu produk (OVOP).
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The impact of leukocyte‐associated RNA retention on platelet RNA‐based cancer detection
Molecular Oncology, EarlyView.Platelets carry RNA signals that may help detect cancer, but platelet samples can also retain RNA from white blood cells. We found that this retained white blood cell signal did not significantly affect machine learning cancer classification, suggesting that the cancer‐related RNA signal in platelets is largely independent of leukocyte‐associated RNA ...
Michał Sieczczyński +12 more
wiley +1 more source
Extraction of HCV-RNA from Plasma Samples: Development towards Semiautomation
International Journal of Analytical Chemistry, 2015 A semiautomated extraction protocol of HCV-RNA using Favorgen RNA extraction kit has been developed. The kit provided protocol was modified by replacing manual spin steps with vacuum filtration. The assay performance was evaluated by real-time qPCR based
Imran Amin +3 more
doaj +1 more source
, 2019 Nominata referente ao volume 9 (2019) da revista Cadernos CIMEAC. A revista agradece a contribuição dos(as) pesquisadores(as) e docentes relacionados para a manutenção da qualidade científica e editorial do ...
2019, Nominata de
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FEBS Open Bio, EarlyView.The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley +1 more source
, 2019 Research Background ‘Scatter 2019’ is a solar-powered installation, sonic composition, and ongoing artistic research project. Sound emanates from twelve loudspeakers that hang from six motorised rotors, which are each mounted at a height of four metres ...
Ferguson, John +3 more
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