Results 51 to 60 of about 4,235,492 (269)
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source
Science, 2020 We begin 2020 (or should I say 20/20) awash in references to ophthalmology. In that vein, we hope to make science clearer and brighter in the months ahead—which brings me to the issue of transparency.
openaire +2 more sources
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
wiley +1 more source
Contens of CJSR 2020, Vol.15, No.2
Zhongguo Jianchuan Yanjiu, 2020 Numerical simulation of ice resistance of ship turning in level ice zone considering fluid effects…NI Baoyu, HUANG Qi, CHEN Wanshou, et al(1) Comparison of hydrodynamic characteristics of SUBOFF with cruciform and X-form rudder arrangement…CHEN Jijun ...
Chinese Journal of Ship Research
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Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Acta Medica Alanya, 2020 We would like to thank our peer reviewers who take the time to submit thoughtful contributions to Acta Medica Alanya. We know how much time and effort goes into writing a good peer review, and we deeply value the input of reviewers who volunteer their ...
Seda Avni̇oğlu, Ahmet Aslan
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A remarkable year with new opportunities for transdisciplinarity
The Journal for Transdisciplinary Research in Southern Africa, 2020 No abstract available.
Johann W.N. Tempelhoff
doaj +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Studi di Storia Medioevale e di Diplomatica: Nuova Serie, 2020 Presentazione dei curatori e autori del volume.
Andrea Gamberini, Marta Luigina Mangini
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