Results 61 to 70 of about 25,032,398 (311)
AAA+ protein unfoldases—the Moirai of the proteome
FEBS Letters, EarlyView.AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley +1 more source
Anotações a “Brasil, 2020: tentativa de diagnóstico”, de David F. L. Gomes
Revista de Ciências do Estado, 2021 Este artigo apresenta alguns comentários ao ensaio de David F. L. Gomes, “Brasil, 2020: tentativa de diagnóstico”. Ao fazer isso, seu principal objetivo é contribuir para um debate crítico sobre nossa sociedade e nosso tempo.
Marcelo Andrade Cattoni de Oliveira
doaj
Sobre Belerofonte/Belorofonte. De Boccaccio a Napoleón [PDF]
, 2009 En un pasaje del Quijote (II, 40), se menciona al jinete del caballo Pegaso como Belorofonte, nombre que los editores desde la segunda edición de 1605, salvo los más conservadores, que no anotan nada peculiar, enmiendan de acuerdo con la tradición ...
Blecua, Alberto, 1941-2020
core +1 more source
Development and Management of Canine Adverse Food Reactions and its Connections to the Grain-Free Dog Food Movement [PDF]
, 2020 Canine Adverse Food Reactions include immunologically-mediated food allergies as well as non-immunological food intolerances. Although popular belief holds grains are responsible for AFR, the majority are aggravated by the common protein sources found in
Dunn, Savannah
core +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Molecular Oncology, EarlyView.Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Revue Annales du patrimoine numéro 20 [PDF]
Annales du Patrimoine, 2020 Revue Annales du patrimoine, Faculté des Lettres et des Arts, Université de Mostaganem, Algérie, N° 20/2020.
Pr Mohammed Abbassa
doaj
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source