Results 81 to 90 of about 25,032,398 (311)

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Pouvoir-Hirak an 2 : les signes de l’impasse ?

L’Année du Maghreb, 2022
Louisa Dris-Aït Hamadouche
doaj   +1 more source

Güncel Yargı Kararları

Anadolu Üniversitesi Hukuk Fakültesi Dergisi, 2021
Bu çalışmada, son dönemde yayınlanan güncel mahkeme kararları arasında dikkat çeken, başta Anayasa Mahkemesi, Yargıtay ve Uyuşmazlık Mahkemesi olmak üzere, çeşitli yargı mercilerince verilmiş kararları ele alan kısa karar özet ve değerlendirmelerine yer ...
Damla Özden Çelt, Burak Işık, Mehmet Arif Tuğ, Gözde Çağlayan Aygün, Asuman İnce Tunçer, Merve Gül Gün Büyüksütçü, Figen Tabanlı, Abdülhamit Yılmaz, Ömer Ali Girgin, Derya Ormanoğlu, Doğukan Küçük, Ayşe Kübra Altıparmak, Gülser Banu Uslu, Mehmet Şükrü Yıldız, Burcu Ezer   +14 more
doaj  

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Front Cover Dinarek

Dinamika Rekayasa, 2020
Agustus 2020
doaj   +1 more source

Chronologie Mauritanie 2020

L’Année du Maghreb, 2022
Camille Evrard, Erin Pettigrew
doaj   +1 more source

Arquivos 2020 [PDF]

Arquivos de Neuro-Psiquiatria, 2020
Hélio Afonso Ghizoni TEIVE, Paulo CARAMELLI   +1 more
openaire   +4 more sources

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Molecular cancer prevention: Intercepting disease

Molecular Oncology, EarlyView.
Oncological practice must evolve, from treating established tumours to proactive cancer interception before clinical manifestation. This will require mechanistic insight into tumour initiation, validated biomarkers of early disease development and redesigned clinical trials, enabling cancer interception to become a core pillar of oncology with the ...
Charlotte Grieco, Tej Pandya, Charles Swanton   +2 more
wiley   +1 more source

Contributors

Journal of Early Modern Studies, 2020
2020 Issue - Authors
doaj   +1 more source