Results 101 to 110 of about 5,796,601 (292)
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
, 2021 Fil: Rector (R). Universidad Nacional de Río Negro. Río Negro, ArgentinaResolución Rectoral Nº 172/2021. Aprobar el dictado del "Seminario Juventud-es: Nadie Como Tú.
Rector (R)
core
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
, 2021 Fil: Consejo Superior de Programación y Gestión Estratégica (P). Universidad Nacional de Río Negro. Río Negro, ArgentinaResolución CSPyGE N° 37/2021. Sustituir el Artículo 2° del Anexo I de la Resolución CSPyGE N° 21/2021. Derogar la Resolución CSPyGE N°
Consejo Superior de Programación y Gestión Estratégica (P)
core
FEBS Open Bio, EarlyView.CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point +7 more
wiley +1 more source
Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies
FEBS Open Bio, EarlyView.We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli +8 more
wiley +1 more source
Proteção e Defesa Civil: introdução à Política Nacional - Curso 1
, 2021 O Curso 1 - Proteção e Defesa Civil: introdução à Política Nacional foi desenvolvido pelo Ceped em parceria com a Sedec, em 2021, e faz parte da Capacitação em Proteção e Defesa Civil.
Oliveira, Marcos de (Conteudista, 2021) +4 more
core
Evaluation du système de surveillance de la méningite dans la région de Niamey, Niger en 2021
Journal of Interventional Epidemiology and Public HealthIntroduction: Les méningites sont une inflammation des méninges. Elle reste un problème de santé publique par sa mortalité élevée et ses séquelles lourds chez les enfants.
Hadjara Aboubacar +4 more
doaj +1 more source
FEBS Open Bio, EarlyView.Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane +11 more
wiley +1 more source