Results 71 to 80 of about 5,796,601 (292)
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
2021 Michigan Geophysical Union Annual Symposium Program Booklet
, 2021 This volume collects student abstracts presented at the 2021 Michigan Geophysical Union symposium.http://deepblue.lib.umich.edu/bitstream/2027.42/167204/1/MGU Booklet 1.5 Final w DOI.pdfDescription of MGU Booklet 1.5 Final w DOI.pdf : MGU 2021 Abstract ...
Michigan Geophysical Union 2021
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Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Resolución Rectoral Nº 688/2021. Sustituir el Anexo III de la Resolución N°165/2021 .
, 2021 Fil: Rector (R). Universidad Nacional de Río Negro. Río Negro, ArgentinaResolución Rectoral Nº 688/2021.
Rector (R)
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, 2021 This book constitutes refereed proceedings of the 20th International Conference on Mathematical Optimization Theory and Operations Research, MOTOR 2021, held in Irkutsk, Russia, in July 2021.
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Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
, 2021 Fil: Consejo de Docencia, Extensión y Vida Estudiantil de Sede Andina (BD). Universidad Nacional de Río Negro. Río Negro, ArgentinaResolución CDEyVE Sede Andina N° 10/2021.
Consejo de Docencia, Extensión y Vida Estudiantil de Sede Andina (BD)
core
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source