Results 101 to 110 of about 14,235,430 (340)
Molecular Oncology, EarlyView.Genetic testing in epithelial ovarian cancer includes both germline and tumor‐testing. This approach often duplicates resources. The current prospective study assessed the feasibility of tumor‐first multigene testing by comparing tumor tissue with germline testing of peripheral blood using an 18‐gene NGS panel in 106 patients.
Elisabeth Spenard +12 more
wiley +1 more source
Labor Law: Bargaining Lockout Held Lawful Absent Interference With Protected Rights or a Proscribed Purpose [PDF]
, 1966 The Sixth Circuit Court of Appeals recently extended the limits within which an employer might lock out his employees. While the Supreme Court has allowed a lockout initiated after an impasse in negotiations between the employer and the union, the Sixth ...
core +1 more source
Screening for lung cancer: A systematic review of overdiagnosis and its implications
Molecular Oncology, EarlyView.Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz +12 more
wiley +1 more source
Doğal Afetler ve Çevre DergisiFloods and flash floods are among the natural disasters that frequently occur in the world and have high destructive power. This study was prepared to evaluate the geographical factors that are effective in the formation of the flood and flash floods ...
Mustafa Recep İrcan, Neşe Duman
doaj +1 more source
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
Stanovení nejistoty měření přetvoření a mechanického napětí získané z odporových tenzometrů [PDF]
, 2017 The article deals with the determination of measurement uncertainty of strain and stress using resistance strain gages. You can find two methods to define the uncertainty in the article, GUF and MMC, and both are applied for measurements carried out with
Dokoupil, Pavel
core +1 more source
2023 ESC Guidelines for the management of cardiomyopathies.
European Heart Journal, 2023 Elena Arbelo +132 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source