Results 81 to 90 of about 4,785,875 (311)
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source
Wiejska femme fatale czy ofiara patriarchatu? Filmowe portrety Jagny Paczesiówny
Acta Universitatis Lodziensis. Folia Litteraria PolonicaNajnowsza adaptacja filmowa powieści Reymonta Chłopi, która w centrum fabuły stawia celebrującą swoją kobiecość i odmienność, tłamszoną przez zbiorowość w imię dobra wspólnoty, Jagnę, zachęca do skonfrontowania tego portretu z filmowymi kreacjami z ...
Monika Bator
doaj +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Mağallaẗ Kulliyyaẗ Al-Adāb, Ǧāmiʿaẗ Al-Zaqāzīqيتناول موضوع البحث دراسة لدور مواقع القنوات الفضائية الإخبارية المصرية والعربية في عرض وتقديم أحداث الحرب الإسرائيلية على قطاع غزة وأهم الأطر الإعلامية التي تم التركيز عليها في تناول ومعالجة هذه الأحداث وعلاقتها بالتعاطف الإنساني والوجداني للجمهور المصري
بسمة بهاء
doaj +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Quantifying the fatal and non-fatal burden of disease associated with child growth failure, 2000–2023: a systematic analysis from the Global Burden of Disease Study 2023 [PDF]
Summary Background: Child growth failure (CGF), which includes underweight, wasting, and stunting, is among the factors most strongly associated with mortality and morbidity in children younger than 5 years worldwide.
GBD 2023 Child Growth Failure Collaborators
core +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
7th Iranian Congress on Brain Mapping 2023
Frontiers in Biomedical TechnologiesNo Abstract.
7th Iranian Congress on Brain Mapping 2023 (ICBM 2023)
doaj
Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source
Global, Regional, and National Burden of Cardiovascular Diseases and Risk Factors in 204 Countries and Territories, 1990-2023 [PDF]
Background: Cardiovascular diseases (CVDs) are the leading cause of mortality and are among the foremost causes of disability globally. CVD burden has continued to increase in most countries since 1990, with trends driven by changing exposures to harmful
Mario D'Oria +4 more
core +1 more source