Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Davis County Utah Pride 2023 Connell O\u27Donovan, Marilyn Johnson Faulkner, Tracy Johnson Faulkner
, 2023 Color photograph (left to right) Connell O\u27Donovan, Marilyn Johnson Faulkner, Tracy Johnson Faulkner at the 2023 Davis County Pride ...
Unknown
core
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Cardiologia HungaricaThe annual report of the Hungarian Myocardial Infarction Registry (HUMIR) is traditionally published in Cardiologia Hungarica. In 2023, we registered 13,451 myocardial infarction (MI) events (STEMI 47.6%, NSTEMI 52.4%), which is 88.5% of all financed ...
Jánosi András
doaj +1 more source
Aktivnosti Centra za istraživanje moderne i savremene historije Tuzla u 2023. godini // Activities of Center for Research of Modern and Contemporary History Tuzla in 2023 [PDF]
Historijski poglediAktivnosti Centra za istraživanje moderne i savremene historije Tuzla u 2023.
Jasmin Jajčević
doaj +1 more source
FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis
FEBS Letters, EarlyView.Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee +7 more
wiley +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Burden of 375 diseases and injuries, risk-attributable burden of 88 risk factors, and healthy life expectancy in 204 countries and territories, including 660 subnational locations, 1990–2023: a systematic analysis for the Global Burden of Disease Study 2023 [PDF]
BACKGROUND: Comprehensive, comparable, and timely estimates of demographic metrics—including life expectancy and age-specific mortality—are essential for evaluating, understanding, and addressing trends in population health.
Mario D'Oria +4 more
core +3 more sources
33rd volume and 4th issue of Current Research in Dental Sciences 2023
Current Research in Dental SciencesIn the 33rd volume and 4th issue of Current Research in Dental Sciences 2023, "Songür E, Aksoy M, Özçelik B, Tulga Öz F. Disinfection effect of gaseous ozone on candida albicans and enterococcus faecalis: A randomized clinical trial in infected primary ...
Erratum E.
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