Results 71 to 80 of about 4,785,875 (311)
The Banco de España Business Activity Survey: 2023 Q4 [PDF]
, 2023 Rationale The Banco de España Business Activity Survey (EBAE) provides real-time information on a broad sample of Spanish firms’ turnover, employment and costs and prices.
Izquierdo, Mario +1 more
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Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Bulletin archéologique des Écoles françaises à l’étrangerThe joint French-Austrian mission of the IFAO, the University of Strasbourg/UMR 7044 Archimède and the Austrian Archaeological Institute (ÖAI) worked at Kūm al-Ḫarāba al-Kabīr Ğirza, in the ruins of ancient Philadelphia, from 8 May to 4 June 2023.
Chang, Ruey-Lin +10 more
openaire +3 more sources
Vision 2023: Turkey’s National Technology Foresight Program – a contextualist description and analysis [PDF]
This paper describes and analyses Vision 2023 Turkish National Technology Foresight Program. The paper is not about a mere description of the activities undertaken. It analyses the Program from a contextualist perspective, where the Program is considered
Erol Taymaz, Turgut Tumer, Ozcan Saritas
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Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
An analysis of the impact of the increase in social security contributions approved in 2023 [PDF]
, 2023 Rationale The latest pension reform, approved in 2023, included three measures to increase social security contributions, aiming to boost social security revenue. This article analyses the impact and calculates the ex ante effect of the changes approved.
Puente, Sergio +2 more
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Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Frontiers in Global Women's HealthBackgroundMaternal health is crucial for women's well-being during pregnancy, childbirth, and postpartum. Antenatal care (ANC) is essential for monitoring health and preventing complications, yet only 35.5% of women in low- and middle-income regions ...
Habtu Kifle Negash +15 more
doaj +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source