Results 81 to 90 of about 4,869,221 (316)

Development of human monoclonal antibodies against TARM1 by yeast display

FEBS Open Bio, EarlyView.
Human monoclonal antibodies against TARM1 are generated by yeast display‐guided selection. These antibodies bind to soluble and cell‐surface forms of TARM1. Also, these antibodies exhibit agonistic activity in the NFAT‐GFP reporter assay, indicating that TARM1 signaling can be functionally modulated by antibodies and suggesting TARM1 as a potential ...
Rikio Yabe, Mayumi Saeki, Masaaki Hashiguchi, Sayaka Ono, Kazuhisa Aoki, Hidetaka Tanno   +5 more
wiley   +1 more source

Étudier l’autre : approches croisées de l’Empire britannique - Compte rendu de la séance du 15 mars 2024

Séminaire « Centres et marges de l’histoire » Consacrée à l'étude de l'autre, cette dernière séance, pour l’année 2023-2024, du séminaire « Centres et marges de l’histoire » a constitué à la fois une synthèse et une ouverture à l'échelle du séminaire. Un
Promotion 2024
core   +1 more source

Iron homeostasis disruption and lipid peroxidation in skeletal muscle during short‐term immobilization

FEBS Open Bio, EarlyView.
14‐day casting‐induced immobilization reduced gastrocnemius muscle mass and increased non‐heme iron and ferritin heavy chain levels. Despite iron accumulation, transferrin receptor 1 and iron regulatory protein 2 were paradoxically upregulated. Lipid peroxidation was elevated without compensatory antioxidant responses.
Haruka Yokogawa, Kazuhiko Higashida, Naoya Nakai   +2 more
wiley   +1 more source

The Dynamics of Processing Knowledge in Citizen Science Projects. Enhancing Participation in Public Citizen Science Formats

Citizen Science: Theory and Practice
Scientific practice has increasingly integrated participatory approaches, with citizen science (CS) serving as a prominent mode of engaging publics in knowledge production.
Eva L. Wyss, Jannik Saal, Andrea Rapp, Stefan Schmunk, Nadine Dietz, Lena Dunkelmann, Nina Korb, Anna Naunheim   +7 more
doaj   +1 more source

V.9 N.2 (2024)

Issue 2 of 2024 of our journal features intriguing contributions that span various scales, urban, architectural, and artistic, while never losing sight of the broader historiographical issues related to the transformations of the city's image.
N.2 (2024), V.9
core   +1 more source

Effect of the over-ageing treatment on the mechanical properties of AA2024 aluminum alloy. [PDF]

, 2012
The evolution of the hardness of the over-ageing AA2024 alloy scale was followed by measurements of Vickers hardness. The nanoindentation is adapted to the determination of elastoplastic properties (hardness and Young’s modulus) of the matrix and also of
Alexis, Joël, Vulpe, Sanda, Radutoiu, Nicoleta, Abrudeanu, Marioara, Marioara Abrudeanu, Petit, Jacques-Alain, Lacroix, Loïc, Rizea, Vasile, Vasile Rizea, Nicoleta Radutoiu, Jacques-Alain Petit, Joël Alexis, Loic Lacroix, Sanda Vulpe   +13 more
core  

Editors’ Best of 2024 [PDF]

JAACAP Open
In our second year as JAACAP Open, which is now available on PubMed Central, we are proud to support the dissemination of among the highest quality research being conducted in our field. Choosing the "best" among stars is always a tall order and most certainly misses the many ways that articles make an impact: is the "best" the most interesting, the ...
Robert R. Althoff, Kara S. Bagot, Joseph Blader, Daniel P. Dickstein, Robert L. Findling, Manpreet K. Singh   +5 more
openaire   +2 more sources

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Suppress or Not to Suppress … CRAFT It: A Targeted Metabolomics Case Study Extracting Essential Biomarker Signals Directly from the Full ¹H NMR Spectra of Horse Serum Samples

Metabolites
Background: There are a few very specific inflammation biomarkers in blood, namely lipoprotein NMe+ signals of protein clusters (GlycA and GlycB) and a composite resonance of phospholipids (SPC).
James Chen, Ayelet Yablon, Christina Metaxas, Matheus Guedin, Joseph Hu, Kenith Conover, Merrill Simpson, Sarah L. Ralston, Krish Krishnamurthy, István Pelczer   +9 more
doaj   +1 more source

Why human connection is the true metric of research success

FEBS Open Bio, EarlyView.
Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan, Mattias Wei Ren Kon, Xavier Coumoul, Fun Man Fung   +3 more
wiley   +1 more source