Results 151 to 160 of about 2,511,182 (316)

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

West Pokot County Annual Development Plan 2025/2026 [PDF]

This Annual Development Plan presents the County Government priorities, proposals and development programmes for financial year 2025/26. The priorities under the plan have been anchored on the County Integrated Development Plan (2023-2027), Public ...
County Government of West Pokot
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Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Trans Nzoia County Annual Development Plan 2025/2026 [PDF]

Article 220 (2) of the Constitution of Kenya, the County Governments Act, 2012 and the Public Finance Management Act (PFMA), 2012 mandate the County Government to prepare development plans which form the basis for appropriation of public funds.
County Government of Trans Nzoia
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Introduction to the Special Issue on Emerging Trends of Systemic Family Therapy Around the World. [PDF]

J Marital Fam Ther
Nadan Y, Guanaes-Lorenzi C, Sesma-Vazquez M.   +2 more
europepmc   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Nakuru City County Annual Development Plan 2025/2026 [PDF]

The ADP 2025/2026 was developed through a collaborative and inclusive process involving all stakeholders, including the public, organized groups, professionals, development partners, and investors.

core   +1 more source

Application of Mobile 3D C-Arm Technology for Diagnostic Imaging of Cleft Palate in an Adult Rhesus Macaque (Macaca mulatta). [PDF]

J Med Primatol
Wegman M, van der Bie J, Maaskant A, Langermans JAM, Casas SS, Stammes MA, Bakker J.   +6 more
europepmc   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Kochi to host International Seaweed Expo, Summit in January 2026 Metro Vaartha dated 1st December 2025 [PDF]

The ICAR-CMFRI will host the 7th India International Seaweed Expo and Summit 2026 (IISE&S 2026), one of the largest gatherings in the seaweed industry, on January 29-30, 2026. The event will be organised by the Indian Chamber of Commerce (ICC), CMFRI and
CMFRI, Library
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