Results 131 to 140 of about 2,511,182 (316)

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

open access: yesFEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani   +3 more
wiley   +1 more source

Garissa County Annual Development Plan 2025/2026 [PDF]

open access: yes
Sections 104, 105 and 108 of the County Government Act, 2012 provides that County Governments are responsible for the preparation of the integrated development plans which guides integrated planning within their counties taking into consideration the ...
County Government of Garissa
core   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

open access: yesFEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi   +6 more
wiley   +1 more source

Wajir County Annual Development Plan 2026/2027 [PDF]

open access: yes
This is the fourth County Annual Development Plan (CADP) in implementation of our transformative five-year County Integrated Development Plan (CIDP) 2023 - 2027.
County Government of Wajir
core   +1 more source

Bibliography of the Journal Metalurgija 1962–2026

open access: yesMetalurgija
Bibliography of the journal Metalurgija from the first issue published in 1962 until the last issue published in 2025, ga. until the 2026. Content: – 1962 - 2026 the publishing of the Metalurgija Journal - pp. 255 – – Abstract - pp.
Ilija Mamuzić
doaj  

Investigating transcription factor dynamics in health and disease using FRAP

open access: yesFEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj   +3 more
wiley   +1 more source

Isiolo County Annual Development Plan 2025/2026 [PDF]

open access: yes
The Isiolo County Annual Development Plan (CADP) for 2025/26 is the third of the five consecutive year plans of the CIDP III (Y1, Y2, Y3, Y4 & Y5). Section 126 of the Public Finance Management Act 2012 clearly states that: Every county government shall ...
County Government of Isiolo
core   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

open access: yesMolecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce   +11 more
wiley   +1 more source

Budget Speech for FY 2025/2026 [PDF]

open access: yes
Mr. Speaker, it is with great honour and privilege that I present to this esteemed house and the people of Kenya the Budget speech for the FY 2025/2026 budget.
The National Treasury and Economic Planning
core  

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

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