Results 191 to 200 of about 3,746,590 (263)

Efficacy of a Computerized Therapeutic Decision-Making Algorithm in a Fracture Liaison Service Targeting Hip Fracture Patients. [PDF]

J Clin Med
Rosenblum RC, Kogan A, Herzberg D, Najjar M, Hershkovich O, Twito O, Lotan R.   +6 more
europepmc   +1 more source

Structure‐Guided Engineering of a Cas12i Nuclease Unlocks Near‐PAMless Genome Editing

Advanced Science, EarlyView.
CRISPR‐Cas nucleases are limited by PAM requirements, restricting genome accessibility. Structure‐guided engineering of the compact Cas12i nuclease SF01 produced three variants with near‐PAMless, enabling efficient editing at diverse 5'‐NNTN‐3' sites. These nucleases expand the editable portion of the human genome more than fourfold, enabling efficient
Qitong Chen, Hanlin Gou, Chao Xu, Sihan Wang, Huitao Zhang, Minglei Song, Mengge Wang, Xingkun Ji, Xiaofei Wei, Yuanyan Tan, Hehua Quan, Pengyu Luo, Hanyu Shou, Pengpeng Liu, Yafeng Liang, Jian‐Kang Zhu   +15 more
wiley   +1 more source

Binding of Hg(I) and Hg(II) Ions to Amyloid-Beta (Aβ) Peptide Variants Affect their Structure and Aggregation. [PDF]

Chembiochem
Berntsson E, Noormägi A, Padari K, Jarvet J, Gräslund A, Pooga M, Palumaa P, Wärmländer SKTS.   +7 more
europepmc   +1 more source

Tobacco Smoke Exposure From Prenatal To Adolescent Periods Drives IBD Pathogenesis: Dynamic DNA Methylation Signatures Across Lifespan Stages

Advanced Science, EarlyView.
This study illustrates that maternal smoking during pregnancy (MSDP) is an independent risk factor for IBD in offspring, and DNA methylation serves as a key mechanistic pathway connecting early‐life smoking exposure with IBD risk in offspring. That highlights the urgent need for preventive interventions targeting prospective parents and minors to ...
Han Zhang, Jianhui Zhao, Jie Chen, Xinyi Ma, Siyun Zhou, Alexandra Noble, Rahul Kalla, Judith Wellens, Kun Liu, Evropi Theodoratou, Jack Satsangi, Xue Li   +11 more
wiley   +1 more source

Comparative Diagnostic Accuracy of MRI and Ultrasound in Meniscal Tear Detection: Evaluating Reliability and Limitations Against Arthroscopic Outcomes. [PDF]

Radiol Res Pract
Noorelahi Y.
europepmc   +1 more source

A Mini‐Spidroin Forms High‐Performance Artificial Spider Silk via Edge‐Cysteine–Locked β‐Sheet Assembly

Advanced Science, EarlyView.
Cysteine‐engineered mini‐spidroins (∼33 kDa) undergo phosphate‐induced liquid–liquid phase separation (LLPS), where disulfide bonds lock partially aligned polyA segments. Subsequent microfluidic spinning promotes directional β‐sheet crystallization, producing fibers with 531 MPa strength and 182 MJ/m3 toughness.
Min Li, Huan Chen, Qi Zhang, Xiaoyun Xu, Yini Zheng, Chunyu Lyu, Weibin Jia, Jun Fan, Fu‐Rong Chen, Wei Liu, Jinlian Hu   +10 more
wiley   +1 more source

Phylogenetic Aspects of Higher Plant Lipid Fatty Acid Profile. [PDF]

Int J Mol Sci
Voronkov A, Ivanova T.
europepmc   +1 more source

Single‐Cell Mitochondrial Lineage Tracing Decodes Fate Decision and Spatial Clonal Architecture in Human Hematopoietic Organoids

Advanced Science, EarlyView.
This study repurposes mitochondrial DNA mutations as endogenous barcodes for lineage tracing in human pluripotent stem cell‐derived organoids. Integrated with transcriptomic and spatial data, it reveals NOTCH‐mediated stromal‐progenitor crosstalk orchestrates clonal dynamics and spatial zonation during early hematopoietic development, offering a non ...
Yan Xue, Junhao Su, Yiming Chao, Lu Liu, Xinyi Lin, Yang Xiang, Mun Kay Ho, Zezhuo Su, Junyi Chen, Zhuojuan Luo, Chengqi Lin, Ruibang Luo, Theo Aurich, Jianfeng Wu, Kelvin Sin Chi Cheung, Yuanhua Huang, Joshua W. K. Ho, Ryohichi Sugimura   +17 more
wiley   +1 more source

Long-Term Efficacy and Safety of Secukinumab in Children and Adolescents with Moderate-to-Severe Chronic Plaque Psoriasis: Four-Year Results of a Randomized, Phase III, Open-Label Trial. [PDF]

Paediatr Drugs
Kingo K, Papanastasiou P, Beissert S, Lazareva S, Villa AV, Bartonova J, Ballona R, Bansal A, Martin R, Fan H, O'Doherty C, Ravichandran S, Magnolo N.   +12 more
europepmc   +1 more source

Modification Strategies of Carbon‐Based Electrodes From Structural Regulation to Multifunctional Integration

Advanced Science, EarlyView.
Tracing the evolution from structural regulation to multifunctional integration, this paper systematically analyzes modification strategies for carbon‐based electrodes. It evaluates how element doping, surface functionalization, and composite material design affect the electrode performance, and offers perspectives on future applications and challenges
Yunlei Wang, Shitao Dou, Yifan Wu, Mingguang Wang, Taibin Wu   +4 more
wiley   +1 more source