Results 91 to 100 of about 75,592 (343)

Testicular adrenal rest tumors in boys with 21-hydroxylase deficiency, timely diagnosis and follow-up

Endocrine Connections, 2018
Background Testicular adrenal rest tumors (TARTs) are found in 30–94% of adult males with congenital adrenal hyperplasia (CAH). We sought to explore TART appearance through yearly ultrasound examination of testes in young boys with CAH, and its ...
M. Kocova, V. Janevska, V. Anastasovska
semanticscholar   +1 more source

Association between Human Leukocyte Antigen Alleles and Neuropathological Outcomes in Lewy Body Disease

Annals of Neurology, EarlyView.
Objective Lewy body disease (LBD) is a complex neurodegenerative disorder characterized by the accumulation of misfolded α‐synuclein in the brain. Neuroinflammation has long been implicated in LBD pathogenesis, and recent genetic studies in Parkinson's disease (a clinical manifestation of LBD) have shown consistent association with the human leukocyte ...
Marios Gavrielatos, Michael G. Heckman, Alexandra I. Soto‐Beasley, Sophia G. Blumenfeld, Xu Hou, Shunsuke Koga, Melissa E. Murray, Koji Kasanuki, Daisuke Ono, Fabienne C. Fiesel, Ryan J. Uitti, Julie A. Fields, Hugo Botha, Vijay K. Ramanan, Kejal Kantarci, Val J. Lowe, Clifford R. Jack, Nilufer Ertekin‐Taner, J. Raphael Gibbs, Bryan J. Traynor, Clifton L. Dalgard, Rodolfo Savica, Jonathan Graff‐Radford, Ronald C. Petersen, R. Ross Reichard, Neill R. Graff‐Radford, Tanis J. Ferman, Bradley F. Boeve, Zbigniew K. Wszolek, Wolfdieter Springer, Ziv Gan‐Or, Emmanuel Mignot, Sonja W. Scholz, Dennis W. Dickson, Owen A. Ross   +34 more
wiley   +1 more source

Measurement of salivary adrenal-specific androgens as biomarkers of therapy control in 21-hydroxylase deficiency.

Journal of Clinical Endocrinology and Metabolism, 2019
BACKGROUND Monitoring of hormonal control represents a key part of the management in congenital adrenal hyperplasia (CAH). Monitoring strategies remain suboptimal as they rely on frequent blood tests and are not specific for adrenal-derived hormones ...
Irina-Alexandra Bacila, J. Adaway, J. Hawley, Sundus Mahdi, R. Krone, L. Patel, S. Alvi, T. Randell, E. Gevers, M. Dattani, T. Cheetham, A. Kyriakou, L. Schiffer, F. Ryan, E. Crowne, J. Davies, S. F. Ahmed, B. Keevil, N. Krone   +18 more
semanticscholar   +1 more source

Deferring surgical treatment of ambiguous genitalia into adolescence in girls with 21-hydroxylase deficiency: a feasibility study

International Journal of Pediatric Endocrinology, 2017
BackgroundGenital surgery in Disorders of Sex Development (DSD) has been an area of debate over the past 20 years. Emerging scientific evidence in the late 1990s defied the then routine practice to surgically align genitalia to the sex of rearing, as ...
P. Bougnères, C. Bouvattier, M. Cartigny, L. Michala   +3 more
semanticscholar   +1 more source

Overview of Encapsulated Lysine and Methionine and Their Impacts on Transition Cow Performance and Health

Animal Research and One Health, EarlyView.
The transition period in dairy cows, spanning 3 weeks before and after calving, is a critical phase characterized by increased nutrient demands, reduced dry matter intake (DMI), and elevated risk of metabolic disorders such as negative nutrient balance (NNB), lipolysis, proteolysis, and oxidative stress.
Mohammed S. Seleem, Samy A. Elsaadawy, Zhaohai Wu, Lu Ma, Todd R. Callaway, Dengpan Bu   +5 more
wiley   +1 more source

Association between genotype, clinical presentation, and severity of congenital adrenal hyperplasia: a review

The Turkish Journal of Pediatrics, 2012
Congenital adrenal hyperplasia (CAH) applies to a family of inherited disorders of steroidogenesis caused by an abnormality in one of the five enzymatic steps necessary in the conversion of cholesterol to cortisol.
Abdulmoein E Al-Agha, Ali H Ocheltree, Masha'el D Al-Tamimi   +2 more
doaj  

Blood pressure effects of SGLT2 inhibitors and GLP‐1 receptor agonists: Mechanisms, trial evidence and Real‐world data

British Journal of Clinical Pharmacology, EarlyView.
SGLT2 inhibitors and GLP‐1 receptor agonists modestly lower blood pressure across diverse patient populations, including those without diabetes. These effects appear largely independent of glycaemic control and offer additive value in high‐risk patients with overlapping comorbidities.
Andrej Belančić, Yusuf Ziya Sener, Marijana Vučković, Joseph Edgar Blais, Almir Fajkić, Emina Sher, Mislav Radić, Josipa Radić   +7 more
wiley   +1 more source

The Use of Routine Laboratory 17-Hydroxyprogesterone for Identification of Cases of 21-Hydroxylase Deficiency Congenital Adrenal Hyperplasia. [PDF]

Clin Endocrinol (Oxf)
ABSTRACT Background Clinical outcome studies of 21‐hydroxylase deficiency congenital adrenal hyperplasia (21OHD CAH) may be subject to selection bias due to incomplete case ascertainment. This study aimed to develop a methodology for identifying existing CAH cases and explore its utility to study clinical outcomes. Methods 17‐hydroxyprogesterone assays
McElvaney J, Ali SR, Frank AR, Longmuir S, McNeilly J, Alimussina M, McGowan R, Faisal Ahmed S.   +7 more
europepmc   +2 more sources

3D‐Printed Protein Models as an Educational Tool in Biochemistry Outreach

Biochemistry and Molecular Biology Education, EarlyView.
ABSTRACT The abstract and complex nature of molecular biology often presents significant challenges for students at all levels of study. Traditional teaching methods, such as the use of 2D diagrams, may not fully convey the intricacies of these topics, leading to difficulties in comprehension and engagement. This study aimed to introduce 3D‐printed and
Oliver Osborne, Siobhan Clennell, Shaun K. Bremner‐Hart   +2 more
wiley   +1 more source

Relationship between adipokines and androgens in children and young adults with congenital adrenal hyperplasia

Frontiers in Endocrinology
IntroductionChildren and young adults with congenital adrenal hyperplasia (CAH) are at increased risk of obesity and insulin resistance. There is evidence that children with CAH have increased visceral adiposity, which has been linked to metabolic ...
Jennifer Apsan, Oksana Lekarev, Charlene Thomas, Yuan-Shan Zhu, Kaela Cohan, Karen Lin-Su   +5 more
doaj   +1 more source