Results 121 to 130 of about 34,531 (209)

Neuroactive steroid exposure impacts neurodevelopment: Comparison of human and rodent placental contribution

Journal of Neuroendocrinology, EarlyView.
Abstract The placenta is a fetal endocrine organ that secretes many neuroactive factors, including steroids, that play critical roles in brain development. The study of the placenta‐brain axis and the links between placental function and brain development represents an emerging research area dubbed “neuroplacentology.” The placenta drives many ...
Claire‐Marie Vacher, Alex Tsompanidis, Morgan R. Firestein, Anna A. Penn   +3 more
wiley   +1 more source

Refsum disease [PDF]

, 2015
Leroy, Bart, Wanders, Ronald JA, Waterham, Hans R   +2 more
core  

Remodeling of the terpenoid metabolism during prolonged phosphate depletion in the marine diatom Phaeodactylum tricornutum

Journal of Phycology, EarlyView.
Abstract Terpenoids are a diverse class of naturally occurring organic compounds, which derive from five‐carbon isoprene units and play crucial roles in physiology, ecological interactions such as defense mechanisms, or adaptation to environmental stresses.
Florian Pruckner, Luca Morelli, Payal Patwari, Michele Fabris   +3 more
wiley   +1 more source

The road less taken: Dihydroflavonol 4‐reductase inactivation and delphinidin anthocyanin loss underpins a natural intraspecific flower colour variation

Molecular Ecology, EarlyView.
Abstract Visual cues are of critical importance for the attraction of animal pollinators, however, little is known about the molecular mechanisms underpinning intraspecific floral colour variation. Here, we combined comparative spectral analysis, targeted metabolite profiling, multi‐tissue transcriptomics, differential gene expression, sequence ...
Darren C. J. Wong, Zemin Wang, James Perkins, Xin Jin, Grace Emma Marsh, Emma Grace John, Rod Peakall   +6 more
wiley   +1 more source

Mechanisms of enteric neuropathy in diverse contexts of gastrointestinal dysfunction

Neurogastroenterology &Motility, EarlyView.
Abstract The enteric nervous system (ENS) commands moment‐to‐moment gut functions through integrative neurocircuitry housed in the gut wall. The functional continuity of ENS networks is disrupted in enteric neuropathies and contributes to major disturbances in normal gut activities including abnormal gut motility, secretions, pain, immune dysregulation,
Julia R. Jamka, Brian D. Gulbransen
wiley   +1 more source

Central mechanisms of emesis: A role for GDF15

Neurogastroenterology &Motility, Volume 37, Issue 3, March 2025.
Abstract Background Nausea and emesis are ubiquitously reported medical conditions and often present as treatment side effects along with polymorbidities contributing to detrimental life‐threatening outcomes, such as poor nutrition, lower quality of life, and unfavorable patient prognosis.
Tito Borner, Allison M. Pataro, Bart C. De Jonghe   +2 more
wiley   +1 more source

BAF60/SWP73 subunits define subclasses of SWI/SNF chromatin remodelling complexes in Arabidopsis

New Phytologist, EarlyView.
Summary Evolutionarily conserved switch‐defective/sucrose nonfermentable (SWI/SNF) ATP‐dependent chromatin remodelling complexes (CRCs) alter nucleosome positioning and chromatin states, affecting gene expression to regulate important processes such as proper development and hormonal signalling pathways.
Sebastian P. Sacharowski, Szymon Kubala, Pawel Cwiek, Jaroslaw Steciuk, Dominika Gratkowska‐Zmuda, Paulina Oksinska, Ernest Bucior, Anna T. Rolicka, Monika Ciesla, Klaudia Nowicka, Saleh Alseekh, Takayuki Tohge, Patrick Giavalisco, Dorota L. Zugaj, Sara C. Stolze, Anne Harzen, Rainer Franzen, Bruno Huettel, Elzbieta Grzesiuk, Mohammad‐Reza Hajirezaei, Hirofumi Nakagami, Csaba Koncz, Alisdair R. Fernie, Tomasz J. Sarnowski   +23 more
wiley   +1 more source

Stereochemical insights into sarpagan and akuammiline alkaloid biosynthesis

New Phytologist, EarlyView.
Summary Sarpagan and akuammiline monoterpenoid indole alkaloids (MIAs) are a class of bioactive plant‐derived compounds with significant pharmaceutical potential. These alkaloids are formed through oxidative cyclization of geissoschizine, catalyzed by homologous cytochrome P450 monooxygenases (CYP) known as sarpagan bridge enzymes (SBEs) and rhazimal ...
Scott Galeung Alexander Mann, Melina Paz‐Galeano, Mohammadamin Shahsavarani, Jacob Owen Perley, Jun Guo, Jorge Jonathan Oswaldo Garza‐Garcia, Yang Qu   +6 more
wiley   +1 more source

Genetic diversity and adaptive evolutionary history of Sapindus in China: insights from whole‐genome resequencing of 100 representative individuals

Plant Biotechnology Journal, EarlyView.
Summary Sapindus is an important forest tree genus with utility in biodiesel, biomedicine, biochemistry and forestry. Similar to many perennial crop plants, its breeding is hampered by long generation times and lack of genetic resources. To understand the genome evolution underlying the important bioeconomic traits, we carried out a common garden ...
Jiming Liu, Guochun Zhao, Yulin Zheng, Yuanyuan Xu, Mianzhi Wang, Lu Li, Caowen Sun, Qiuyang He, Rami‐Petteri Apuli, Joan Jing Yi Jong, Jia Jun Ngiam, Andrey Vaulin, Roy Jun Kai Tham, Liming Jia, Zhong Chen, Jarkko Salojärvi   +15 more
wiley   +1 more source

Molecular changes in agroinfiltrated leaves of Nicotiana benthamiana expressing suppressor of silencing P19 and coronavirus‐like particles

Plant Biotechnology Journal, EarlyView.
Summary The production of coronavirus disease 2019 vaccines can be achieved by transient expression of the spike (S) protein of severe acute respiratory syndrome coronavirus 2 in agroinfiltrated leaves of Nicotiana benthamiana. Relying on bacterial vector Agrobacterium tumefaciens, this process is favoured by co‐expression of viral silencing suppressor
Louis‐Philippe Hamel, Francis Poirier‐Gravel, Marie‐Ève Paré, Rachel Tardif, Marc‐André Comeau, Pierre‐Olivier Lavoie, Andréane Langlois, Marie‐Claire Goulet, Dominique Michaud, Marc‐André D'Aoust   +9 more
wiley   +1 more source