Results 131 to 140 of about 57,073 (302)

11β-Hydroxylase deficiency

, 2018
11Β-hydroxylase deficiency (11ΒOHD) is a rare variant of congenital adrenal hyperplasia causing reduced or absent activity of the 11Β-hydroxylase (CYP11B1) enzyme.
Krupali Bulsari, Falhammar, Henrik, Henrik Falhammar, Bulsari, Krupali   +3 more
core   +1 more source

Harnessing microbial power to degrade hydrocarbon‐based plastics

mLife, EarlyView.
Abstract The growing global plastic waste crisis demands the development of urgent, effective, and sustainable solutions. While conventional recycling methods present intrinsic limitations, microbial biodegradation of plastic waste has emerged as a promising alternative.
Hui Li, Xuanyu Tao, Lina Sun, Aifen Zhou, Jizhong Zhou   +4 more
wiley   +1 more source

Long-read sequencing solves complex structure of CYP21A2 in a large 21-hydroxylase deficiency cohort_Supplemental Table 1.xlsx

Long-read sequencing solves complex structure of CYP21A2 in a large 21-hydroxylase deficiency cohort_Supplemental Table ...
Wenjuan Qiu (11161892), Yongguo Yu (9710830), Ruifang Wang (18112462), Xiaomei Luo (502040)   +3 more
core   +1 more source

Current Cell/Organoid and Animal Models for Primary Sclerosing Cholangitis

Portal Hypertension &Cirrhosis, EarlyView.
Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease with limited therapeutic options and a marked risk of progression to biliary fibrosis, cirrhosis, and malignancy. Progress in PSC research has been hindered by the lack of models that faithfully recapitulate the complex biliary microenvironment and disease heterogeneity ...
Qigu Yao, Sheng Cheng, Qiaoling Pan, Jiong Yu, Hongcui Cao   +4 more
wiley   +1 more source

Amino acid vectorization of salicylic acid enables efficient activation of NPR1‐dependent defense without phytotoxicity

Pest Management Science, EarlyView.
Amino acid‐vectorized salicylic acid activates PR1/NPR1‐dependent defenses without phytotoxicity, showing an efficient strategy for controlled delivery and enhanced plant immunity. Abstract BACKGROUND Addressing global food security under rapid population growth and climate change requires sustainable strategies to protect crops from pathogens while ...
Ruth Oussou, Benoit Guichard, Loïc Lemée, Vincent Lebeurre, Cécile Marivingt‐Mounir, Jean‐François Chollet, Sylvain La Camera   +6 more
wiley   +1 more source

Development of a physiologically‐based pharmacokinetic model for Ritonavir characterizing exposure and drug interaction potential at both acute and steady‐state conditions

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 523-539, March 2025.
Abstract Ritonavir (RTV) is a potent CYP3A inhibitor that is widely used as a pharmacokinetic (PK) enhancer to increase exposure to select protease inhibitors. However, as a strong and complex perpetrator of CYP3A interactions, RTV can also enhance the exposure of other co‐administered CYP3A substrates, potentially causing toxicity.
Lien Thi Ngo, Woojin Jung, Tham Thi Bui, Hwi‐yeol Yun, Jung‐woo Chae, Jeremiah D. Momper   +5 more
wiley   +1 more source

Evaluation of Potential Hormonal Activities of Ashwagandha (Withania somnifera)

Phytotherapy Research, EarlyView.
ABSTRACT Ashwagandha is a widely used herb in traditional medicine systems, particularly Ayurveda. Despite its extensive tradition, growing concerns regarding its potential endocrinological effects have prompted scientific scrutiny. This review systematically evaluates the current preclinical, clinical, and case study evidence concerning AS's effects ...
Günter Vollmer, Thomas Brendler
wiley   +1 more source

21-Hydroxylase Deficiency [PDF]

, 2020
openaire   +1 more source

Flavonoids in Nasal Therapeutics: Biological Activities, Delivery Challenges, and Formulation Strategies–A Systematic Review

Phytotherapy Research, EarlyView.
Overview of the therapeutic potential of flavonoids in nasal delivery systems, highlighting their benefits to the human nasal cavity, and applications in the treatment of respiratory and brain‐related diseases. ABSTRACT Flavonoids represent a significant group of secondary metabolites.
Jeniffer Viviana Ramirez Hernández, Sara Elis Bianchi, Flávia Nathiely Silveira Fachel, Elizandra Braganhol, Sheila Porto de Matos, Valquíria Linck Bassani   +5 more
wiley   +1 more source

Congenital Adrenal Hyperplasia with Combined 21-hydroxylase deficiency and 17α-hydroxylase/17,20-lyase deficiency: An undervirilized male

21-hydroxylase deficiency stands as the most prevalent form of congenital adrenal hyperplasia, primarily resulting from mutations in the CYP21A2 gene. On the other hand, mutations within the CYP17A1 gene lead to 17 alpha-hydroxylase/17,20-lyase enzyme ...
GÜL ŞİRAZ, ÜLKÜ, GÖK, EBRU, BERBER, UĞUR, KENDİRCİ, MUSTAFA, Erdogan, Murat, KARA, LEYLA, KURTOĞLU, Selim, SARIKAYA, EMRE, HATİPOĞLU, NİHAL, ÇİÇEK, DİLEK   +9 more
core   +1 more source