Results 171 to 180 of about 19,232 (256)

Empowering Masters of Creative Problem Solvers: The Impact of STEM Professional Development Training on Teachers' Attitudes, Self-Efficacy, and Problem-Solving Skills. [PDF]

J Intell
Durnali M, Gökbulut B.
europepmc   +1 more source

Development and Release of the Munich UICC Staging Tool (MUST): Advancing UICC Staging in Real‐World Data With Insights From Pancreatic and Stomach Cancer

International Journal of Cancer, EarlyView.
Accurate cancer staging is essential for cancer research and treatment evaluation. However, real‐world data often include incomplete or inconsistent UICC staging classifications. The presented Munich UICC Staging Tool (MUST) automates UICC stage derivation from TNM classifications and tumor characteristics, incorporating novel real‐world data rules to ...
Brigitte Kühnel, Sophie Schneiderbauer, Sebastian Lange, Dirk Wilhelm, Helmut Friess, Marcus Feith, Ursula Ehmer, Florian Bassermann, Julian W. Holch, Stefan M. Munker, Jens Neumann, Jens Werner, Hubert J. Stein, Theres Fey, Ulrich Mansmann, Hana Algül, Karin Berger‐Thürmel, H. Carlo Maurer, Daniel Nasseh   +18 more
wiley   +1 more source

Progress of metabolomics‐centric multi‐omics research in medicine

iMetaOmics, EarlyView.
The graphical abstract illustrates a holistic roadmap for metabolomics‐centric multi‐omics integration in medical research. The upper panel depicts the technological transition from traditional bulk analysis to high‐resolution single‐cell and spatial methodologies, specifically addressing inherent challenges such as molecular complexity and dynamic ...
Ziyi Wang, Shiwen Deng, Xiaoxu Wang, Xiao Chang, Na Guo, Peng Chen, Hongjun Yang   +6 more
wiley   +1 more source

Are we ready for AI-augmented generalists? [PDF]

BMJ Evid Based Med
Zhang J.
europepmc   +1 more source

Hypervision Proton Surgery: The Future Direction of Proton Therapy

iNew Medicine, EarlyView.
ABSTRACT Proton beams provide unique physical advantages characterized by a low entrance dose, negligible exit dose, and a sharp Bragg peak, which enable superior sparing of normal tissues and support safe dose escalation for improved tumor control. However, conventional photon‐based fractionation remains widely used in proton therapy, where prolonged ...
Li Li, Shuanghu Yuan
wiley   +1 more source

Why people matter in 21st century hydrology: lessons learnt from flood forecasting and warning. [PDF]

Philos Trans A Math Phys Eng Sci
Speight L.
europepmc   +1 more source

Respiratory Syncytial Virus Under the Lens of Structure: From Prefusion Stabilization to Next‐Generation Immunotherapies

iNew Medicine, EarlyView.
This illustration integrates key concepts covered in the review, including high‐risk populations, viral structure, host entry factors, the replication cycle, and licensed antibody‐based prevention strategies. ABSTRACT Respiratory syncytial virus (RSV) is a negative‐sense RNA virus belonging to the genus Orthopneumovirus within the family Pneumoviridae.
Zekai Cheng, Qianqian Wang, Jiachen Zhang, Sandra Chiu   +3 more
wiley   +1 more source

Integrating digital tools and constructivist learning: a ubiquitous learning framework for enhancing creativity in music education. [PDF]

BMC Psychol
Aoonlamai N, Kwangmuang P.
europepmc   +1 more source

Adss1–HDAC3 Interaction: A Novel Mechanism for Epigenetic Regulation of Metabolism in Adipose Tissue

iNew Medicine, EarlyView.
ABSTRACT Obesity and its related metabolic disorders have emerged as global public health challenges with underlying mechanisms involving an imbalance between energy storage and expenditure in the adipose tissue. In recent years, with the deepening research on adipose tissue metabolism, the cross talk between metabolic enzymes and epigenetic regulation
Jiarui Zhao, Jingjing Sun, Yan Lu, Ying Yang   +3 more
wiley   +1 more source

SUMOylation regulates tumorigenesis and progression: Molecular mechanisms and therapeutic applications

Interdisciplinary Medicine, EarlyView.
SUMOylation, a dynamic post‐translational modification, acts as a master regulator at the heart of tumor malignancy. Our work delineates how the SUMOylation cycle—mediated by E1/E2/E3 enzymes and reversed by SENPs—orchestrates multiple hallmarks of cancer. The central pathway converges on three critical pathological axes: 1.
Yimao Wu, Zichang Chen, Yinting Hu, Gokhan Zengin, Qian Zhang, Meng‐Yao Li, Wenlong Sun   +6 more
wiley   +1 more source