Results 211 to 220 of about 2,371,621 (363)

The effects of sodium–glucose cotransporter 2 inhibitors on the ‘forgotten’ right ventricle

open access: yesESC Heart Failure, Volume 12, Issue 2, Page 1045-1058, April 2025.
Abstract With the progress in diagnosis, treatment and imaging techniques, there is a growing recognition that impaired right ventricular (RV) function profoundly affects the prognosis of patients with heart failure (HF), irrespective of their left ventricular ejection fraction (LVEF).
Liangzhen Qu, Xueting Duan, Han Chen
wiley   +1 more source

Dynamic clinical trial success rates for drugs in the 21st century. [PDF]

open access: yesNat Commun
Zhou Y   +18 more
europepmc   +1 more source

Consensus findings of an International Workshops on Genotoxicity Testing workshop on using transcriptomic biomarkers to predict genotoxicity

open access: yesEnvironmental and Molecular Mutagenesis, EarlyView.
Abstract Gene expression biomarkers have the potential to identify genotoxic and non‐genotoxic carcinogens, providing opportunities for integrated testing and reducing animal use. In August 2022, an International Workshops on Genotoxicity Testing (IWGT) workshop was held to critically review current methods to identify genotoxicants using ...
Roland Froetschl   +14 more
wiley   +1 more source

Seismic Design of Concrete Dams: An Integrated Risk‐Informed Performance‐Based (RIPB) Framework

open access: yesEarthquake Engineering &Structural Dynamics, EarlyView.
ABSTRACT This paper advances the integration of risk‐informed principles into the seismic design of dams—a domain long guided by standards‐based, largely deterministic approaches. While performance‐based earthquake engineering is well established for buildings and bridges, its systematic adoption in dam engineering remains limited. We first address two
M. Amin Hariri‐Ardebili, Larry K. Nuss
wiley   +1 more source

Topographically-controlled contribution of avalanches to glacier mass balance in the 21st century. [PDF]

open access: yesNat Commun
Kneib M   +11 more
europepmc   +1 more source

Comprehensive Feasibility Study of Solar Power Plants

open access: yesEnergy Science &Engineering, EarlyView.
ABSTRACT The global transition to solar energy is frequently impeded by high project failure rates, largely due to feasibility assessments that emphasize geographic and economic aspects while overlooking critical technical, environmental, and socio‐administrative dimensions.
Seyyed Mohammad Hadi Mohammadi   +2 more
wiley   +1 more source

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