Results 111 to 120 of about 2,808,871 (212)
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Gauge theory constraints on the fermion-boson vertex [PDF]
, 1995 In this thesis we investigate the role played by fundamental properties of QED in determining the non-perturbative fermion-boson vertex. These key features are gauge invariance and multiplicative renormalisability. We use the Schwinger-Dyson equations as
Kizilersü, Ayşe, Kizilersu, A
core
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Dimensional regularisation and gauge theories [PDF]
, 1994 Dimensional regularisation is formulated without using the assumption that f d(^D)k(k(^2))(^n) = 0. Alternative definitions of ϵ(_kλµv) and γ(^5) are also considered.
Shaban, N.T, Shaban, Neil Tamim
core
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Basic Principles in 23-, 25-, and 27-Gauge Pars Plana Vitrectomy
, 2019 Although sutureless techniques for 20-gauge vitrectomy had previously been described, it was not until the advent of 25-gauge vitrectomy that transconjunctival sutureless vitrectomy became popular.
Weng Onn Chan +5 more
core +1 more source
Comparison of Characteristics and Clinical Outcomes between 27 versus 23 Vitrectomy Gauge in Diabetic Vitrectomy Surgery [PDF]
Al-Azhar International Medical JournalBackground: The most serious type of diabetic eye disease, proliferative diabetic retinopathy, affects about 1.4% of all diabetics around the world.Aim: To find out how well 27-G and 23-G probes work in diabetic vitrectomy surgery by looking at their ...
doaj +1 more source
Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding
FEBS Letters, EarlyView.In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança +2 more
wiley +1 more source