Results 191 to 200 of about 171,840 (265)

BIN1 and ALDH1B1 Deficiency in Colonic Smooth Muscle Drives Mitochondrial Dysfunction and Fibrosis in Slow‐Transit Constipation

Advanced Science, EarlyView.
Slow‐transit constipation (STC) is a disabling motility disorder with unclear smooth‐muscle mechanisms. Spatial proteomic analysis of STC patient colon reveals both the central pathogenic role of smooth muscle cells (SMCs) in STC and novel regulators of intestinal motility, BIN1 and ALDH1B1.
Jianbo Liu, Hao Zhang, Wenhao Qiao, Ran Liu, Jie Sun, Xiaopei Li, Qin Li, Dongbo Zhao, Dawei Chen, Jingxin Li, Shuxiao Dong   +10 more
wiley   +1 more source

Nucleophilic cyclization of <i>N</i>-propargylated pyrazole-5-carboxylates: synthesis of pyrazolo[1,5-<i>a</i>]pyrazin-4(5<i>H</i>)-one derivatives. [PDF]

Turk J Chem
Mengeş MF, Tan Uygun M.
europepmc   +1 more source

Single‐Cell Transcriptomic Analysis of Tumor Heterogeneity and the Microenvironment in Pseudomyxoma Peritonei

Advanced Science, EarlyView.
This study presents a single‐cell atlas of pseudomyxoma peritonei spanning primary and paired metastatic lesions. Distinct epithelial substates, stromal remodeling, immune exclusion, lipid metabolic reprogramming, and a candidate angiogenic network were identified in metastatic lesions.
Xi Li, Lei Wang, Lei Ai, Zimeng Li, Zhaochangci Chen, Yuchen Luo, Tianran Zhang, Mengjia Liao, Songhao Wang, Jiajia Cui, Ke Liu, Chengxian Guo, Guodong Liu, Jiye Yin, Wei Wu   +14 more
wiley   +1 more source

Compound 17 Inhibits Lung Cancer Progression via Inducing Cellular Apoptosis and Blocking TNF Signaling Pathway Activation. [PDF]

Int J Mol Sci
Zhang J, Zhang Y, Zhao Y, Shen H, Zhao Y, Teng H.   +5 more
europepmc   +1 more source

Optimized Ex Vivo Human Liver Slice Culture Maintains Extended Viability and Function for Hepatotoxicity Testing

Advanced Science, EarlyView.
An optimized ex vivo human liver slice culture system preserves tissue architecture, hepatocyte function, and immune‐stromal complexity for at least five days. By refining slice thickness, oxygenation, air‐liquid interface, and extracellular matrix support, the platform enables human‐relevant hepatotoxicity testing and mechanistic studies, offering a ...
Huiche Feng, Cinzia Esposito, Andrej Benjak, Matthias S. Matter, Miriam Cieri, Camilla De Carlo, Philipp Sedlaczek, Fabian Haak, Mattia Marinucci, Gabriel Fridolin Hess, Otto Kollmar, Mairene Coto‐Llerena, Luca Di Tommaso, Visar Vela, Lukas Bubendorf, Luigi M. Terracciano, Charlotte K. Y. Ng, Salvatore Piscuoglio   +17 more
wiley   +1 more source

Synthesis, Biological Evaluation, and Theoretical Study of Indenoquinolinylphosphine Oxide Derivatives as Topoisomerase 1 Inhibitors and Antiproliferative Agents. [PDF]

ChemMedChem
Rodriguez A, Formoso E, Knudsen BR, Tesauro C, Fuertes M, Alonso C.   +5 more
europepmc   +1 more source

Bifunctional Metformin-Phenolic Hybrids with Improved Anticancer and Antioxidant Properties: Evaluation on Glioma Cells. [PDF]

Int J Mol Sci
Delehedde C, Chocry M, Nguyen C, Asteian A, Robin M, Leloup L, Cassien M, Mercier A, Culcasi M, Kovacic H, Pietri S.   +10 more
europepmc   +1 more source

Ni(II) Chiral Square-Complex-Mediated Mannich Alkynylation for the Synthesis of Enantiomerically Enriched Unnatural α‑Amino Acids with Collagenase Inhibitory Activity. [PDF]

ACS Omega
Grigoryan A, Hayriyan L, Gevorgyan H, Sargsyan A, Langer P, Saghyan A, Mkrtchyan A.   +6 more
europepmc   +1 more source

Crystal structure and Hirshfeld surface analysis of 10-(3-benzyl-thio-phen-2-yl)-5,5-di-fluoro-5<i>H</i>-4λ⁴,5λ⁴-di-pyrrolo-[1,2-<i>c</i>:2',1'-<i>f</i>][1,3,2]di-aza-borinine. [PDF]

Acta Crystallogr E Crystallogr Commun
Polianskaia ZA, Larionov AS, Khrustalev VN, Akkurt M, Manahelohe GM, Guliyeva NA, Hasanov KI.   +6 more
europepmc   +1 more source

Azo-Povarov Cycloaddition of <i>N</i>-Carbonyl Aryldiazenes with <i>cis</i>,<i>trans</i>-Cycloocta-1,5-diene as a Fluorogenic Click Reaction for the Synthesis of Cinnoline Derivatives. [PDF]

J Org Chem
Jiménez-Aberásturi X, Vicario J, Abendroth F, Vázquez O, de Los Santos JM.   +4 more
europepmc   +1 more source