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Novel Halolactones Derived from Vanillin: Design, Synthesis, Structural Characterization, and Evaluation of Antiproliferative and Hemolytic Activities [PDF]
MoleculesA series of novel γ-halo-δ-lactones and δ-halo-γ-lactones bearing a phenolic ring at the β-position were synthesized from vanillin. The divergent seven-step synthetic route commenced with the benzyl protection of the hydroxy group of the starting ...
Anna Dunal +7 more
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Stereoselective synthesis of whisky lactone isomers catalyzed by bacteria in the genus Rhodococcus
Frontiers in Microbiology, 2023 Whisky lactone is a naturally occurring fragrance compound in oak wood and is widely used as a sensory additive in food products. However, safe and efficient methods for the production of its individual enantiomers for applications in the food industry ...
Dawid Hernik +5 more
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Antioxidants, 2022 Paraoxonases (PONs) are a family of hydrolytic enzymes consisting of three members, PON1, PON2, and PON3, located on human chromosome 7. Identifying the physiological substrates of these enzymes is necessary for the elucidation of their biological roles ...
Chrysan J. Mohammed +8 more
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Frontiers in Plant Science, 2022 Arnica montana L. (AM, Asteraceae) is a perennial, herbaceous vascular plant species of commercial importance. The flower heads’ pharmacological properties are attributed mainly to sesquiterpene lactones (SLs), with phenolic acids and flavonoids also ...
Anja Greinwald +6 more
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Molecules, 2021 Background: The study investigated four flavanone-derived γ-oxa-ε-lactones: a parent unsubstituted compound and its three derivatives with the methoxy group in positions 2′, 4′ and 8. Our objective was to find out if the introduction of the methoxy group
Aleksandra Pawlak +7 more
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Synthesis and biological evaluation of novel N-α-haloacylated homoserine lactones as quorum sensing modulators [PDF]
, 2014 Novel N-α-haloacylated homoserine lactones, in which a halogen atom was introduced at the α-position of the carbonyl function of the N-acyl chain, have been studied as quorum sensing (QS) modulators and compared with a library of natural N-acylated ...
De Kimpe, Norbert +4 more
core +2 more sources
Microbial Reduction of Ketopantoyl Lactone to Pantoyl Lactone [PDF]
Applied Microbiology, 1974 The results of a microbial survey study have shown that the ability to reduce added ketopantoic acid (or ketopantoyl lactone) and accumulate pantoic acid (or pantoyl lactone) in the growth medium is widespread among diverse fungi. The reductions generally proceeded with less than full stereoselectivity.
R P, Lanzilotta +2 more
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Biomolecules, 2021 Alzheimer’s disease (AD) is a gradually growing irreversible illness of the brain that almost affects every fifth person (aged > 80 years) in the world. World Health Organization (WHO) also revealed that the prevalence of this disease will enhance (upto ...
Ashwani Arya +12 more
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Synthesis and analysis of stable isotope-labelled N-acyl homoserine lactones [PDF]
, 2016 Aliphatic aldehydes were deuterated at the alpha-position via a base-catalyzed exchange reaction with D2O. These deuterated building blocks were used for the synthesis of labelled analogues of quorum sensing signal molecules belonging to the three major ...
De Kimpe, Norbert +3 more
core +2 more sources
Synthesis of Spiroisoxazolines by 1,3-Dipolar Cycloaddition
Molecules, 1997 The cycloaddition of the chiral nitrile oxide 1 to 1-R-substituted 3,3-methylene-5,5-dimethyl-2-pyrrolidinones 2 (where R is H, n-butyl-, 1,1-dimethylethoxycarbonyl-, 1-methylethenyl- and acetyl-) proceeds regioselectively under the formation of ...
Peter Ertl +3 more
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