Results 1 to 10 of about 584 (88)

Fungal Strains as Catalysts for the Biotransformation of Halolactones by Hydrolytic Dehalogenation with the Dimethylcyclohexane System [PDF]

Molecules, 2012
Bicyclic chloro-, bromo- and iodo-γ-lactones with dimethylcyclohexane rings were used as substrates for bioconversion by several fungal strains (<em>Fusarium</em>, <em>Botrytis</em> and <em>Beauveria</em>). Most of the
Małgorzata Grabarczyk, Grabarczyk Małgorzata   +1 more
exaly   +4 more sources

Community-integrated multi-omics facilitates screening and isolation of the organohalide dehalogenation microorganism [PDF]

The Innovation, 2023
Summary: A variety of anthropogenic organohalide contaminants generated from industry are released into the environment and thus cause serious pollution that endangers human health.
Yiqun Huang, Lingyu Wen, Lige Zhang, Jijun Xu, Weiwei Wang, Haiyang Hu, Ping Xu, Zhao Li, Hongzhi Tang   +8 more
doaj   +2 more sources

Continuous Spectrophotometric Assay for Defluorinase and Dechlorinase Activities With α-Halocarboxylic Acids. [PDF]

Microb Biotechnol
Microbial hydrolytic defluorinases and dechlorinases assayed by coupling the reaction product to NAD‐linked dehydrogenases will facilitate screening for and characterising new and known enzymes. ABSTRACT Many environmental pollutants have a fluorine or chlorine atom on a carbon atom adjacent to a carboxylic acid.
Ronnander M, Dodge AG, O'Neal E, Pauls C, Hanson J, Christenson JK, Wackett LP.   +6 more
europepmc   +2 more sources

New Hydroxylactones and Chloro-Hydroxylactones Obtained by Biotransformation of Bicyclic Halolactones and Their Antibacterial Activity [PDF]

Molecules
The aim of this study was to obtain new halolactones with a gem-dimethyl group in the cyclohexane ring (at the C-3 or C-5 carbon) and a methyl group in the lactone ring and then subject them to biotransformations using filamentous fungi.
Małgorzata Grabarczyk, Anna Duda-Madej, Fedor Romanenko, Gabriela Maciejewska, Wanda Mączka, Agata Białońska, Katarzyna Wińska   +6 more
doaj   +2 more sources

Combination of a UPO-Based Epoxidation With a Subsequent Ring-Opening Reaction for the Synthesis of Amino Alcohols. [PDF]

Chembiochem
The synthesis of aromatic amino alcohols via a combination of an unspecific peroxygenase‐catalysed reaction, oxyfunctionalization, and addition of selected nucleophiles and electrophiles in a highly atom‐efficient manner was investigated. This study presents the design to aim for an atom‐efficient chemo‐enzymatic synthesis route towards aromatic amino ...
Last S, Dietz N, Weissenborn MJ, von Langermann J.   +3 more
europepmc   +2 more sources

Macroalgal microbiomes unveil a valuable genetic resource for halogen metabolism [PDF]

Microbiome
Background Macroalgae, especially reds (Rhodophyta Division) and browns (Phaeophyta Division), are known for producing various halogenated compounds. Yet, the reasons underlying their production and the fate of these metabolites remain largely unknown ...
Anna Lavecchia, Bruno Fosso, Aschwin H. Engelen, Sara Borin, Caterina Manzari, Ernesto Picardi, Graziano Pesole, Antonio Placido   +7 more
doaj   +2 more sources

EnzRetro: Enzymatic Retrosynthetic Planning With Site-Specific Reaction Edits Based on Sequence Generative Architecture. [PDF]

Exploration (Beijing)
EnzRetro bridges retrosynthesis planning and enzymatic engineering through site‐specific reaction edits. This end‐to‐end framework integrates pathway synthesis and enzyme identification into a unified process, achieving superior accuracy and enabling the efficient reconstruction of diverse biosynthetic pathways.
Cao Y, Chen H, Zhang T, Zhao X, Li B, Zheng X.   +5 more
europepmc   +2 more sources

The Operon Encoding Hydrolytic Dehalogenation of 4-Chlorobenzoate Is Transcriptionally Regulated by the TetR-Type Repressor FcbR and Its Ligand 4-Chlorobenzoyl Coenzyme A [PDF]

Applied and Environmental Microbiology, 2021
Minggen Cheng, Pingping Zhu, Xin Yan
exaly   +2 more sources

Designing Enzymatic Reactivity with an Expanded Palette. [PDF]

Chembiochem
Innovation in biocatalysis is rapidly increasingly the diversity of catalytic reactivity that can be mediated by enzymes, addressing a key bottleneck for their widespread adoption in industrial chemical synthesis. A key approach to this is building enzymes with unnatural catalytic components that provide an expanded palette with new possibilities for ...
Leveson-Gower RB.
europepmc   +2 more sources

Evolutionary obstacles and not C-F bond strength make PFAS persistent. [PDF]

Microb Biotechnol
C–F bonds can be cleaved by microbes. However, evolution must overcome many obstacles to biodegrade PFAS. Abstract The fate of organic matter in the environment, including anthropogenic chemicals, is largely predicated on the enzymatic capabilities of microorganisms.
Wackett LP.
europepmc   +2 more sources