Continuous evolution of a halogenase enzyme with improved solubility and activity for sustainable bioproduction [PDF]
Nature CommunicationsHalogenation enhances the stability and function of pharmaceuticals, biomaterials, and industrial compounds. However, chemical halogenation of molecules and peptides can lack stereoselectivity and require the use of toxic chemicals.
Andre Arashiro Pulschen +10 more
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Microbially-mediated halogenation and dehalogenation cycling of organohalides in the ocean [PDF]
Nature CommunicationsMicrobially mediated organohalide cycling in the ocean has profound implications for global biogeochemical cycles and climate, but the geographic distribution and diversity of the halogenation-dehalogenation cycling microorganisms remain unknown.
Na Zhou +8 more
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Pillar[5]arene-catalyzed anti-Markovnikov halogenations through cationic intermediates stabilization in confined spaces [PDF]
Nature CommunicationsThe confinement of reactants within catalytic cavities is important for achieving efficient and selective chemical transformations. Macrocyclic organic covalent hosts, which mimic enzymatic environments, offer well-defined, tunable cavities capable of ...
Tianyue Xu +4 more
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Halogenation and Dehalogenation Potential of Microorganisms in Yangtze River Waters [PDF]
MicroorganismsThe discharge of pollutants into rivers has been increasing with the rapid industrial development and extensive agricultural use of pesticides and herbicides. Halogenated organic compounds (HOCs) represent a significant class of environmental pollutants.
Zhixuan Wang +3 more
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The Halogenation Effects of Electron Acceptor ITIC for Organic Photovoltaic Nano-Heterojunctions
Nanomaterials, 2021 Molecular engineering plays a critical role in the development of electron donor and acceptor materials for improving power conversion efficiency (PCE) of organic photovoltaics (OPVs). The halogenated acceptor materials in OPVs have shown high PCE. Here,
Yu Wang +7 more
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Halogenation of Peptides and Proteins Using Engineered Tryptophan Halogenase Enzymes
Biomolecules, 2022 Halogenation of bioactive peptides via incorporation of non-natural amino acid derivatives during chemical synthesis is a common strategy to enhance functionality.
Barindra Sana +6 more
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Frontiers in Bioengineering and Biotechnology, 2022 Biocatalytic C-H halogenation is becoming increasingly attractive due to excellent catalyst-controlled selectivity and environmentally benign reaction conditions. Significant efforts have been made on enzymatic halogenation of industrial arenes in a cost-
Eunice Hui Yen Li +6 more
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Halogenation in Fungi: What Do We Know and What Remains to Be Discovered?
Molecules, 2022 In nature, living organisms produce a wide variety of specialized metabolites to perform many biological functions. Among these specialized metabolites, some carry halogen atoms on their structure, which can modify their chemical characteristics ...
Bastien Cochereau +4 more
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Halogenation generates effective modulators of amyloid-Beta aggregation and neurotoxicity. [PDF]
PLoS ONE, 2013 Halogenation of organic compounds plays diverse roles in biochemistry, including selective chemical modification of proteins and improved oral absorption/blood-brain barrier permeability of drug candidates.
H Edward Wong +2 more
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Mechanochemical halogenation of unsymmetrically substituted azobenzenes
Beilstein Journal of Organic Chemistry, 2022 The direct and selective mechanochemical halogenation of C–H bonds in unsymmetrically substituted azobenzenes using N-halosuccinimides as the halogen source under neat grinding or liquid-assisted grinding conditions in a ball mill has been described ...
Dajana Barišić +4 more
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