Results 41 to 50 of about 12,869 (241)

Halogenation of tyrosine perturbs large-scale protein self-organization [PDF]

, 2022
Protein halogenation is a common non-enzymatic post-translational modification contributing to aging, oxidative stress-related diseases and cancer. Here, we report a genetically encodable halogenation of tyrosine residues in a reconstituted prokaryotic ...
Kendall, O., Dragelj, J., Dragelj, Jovan, Schwille, Petra, Baumann, Tobias, Sun, H., Mroginski, M., Budisa, Nediljko, Kendall, Olivia, Jia, Haiyang, Schwille, P., Budisa, N., Jia, H., Sun, Huan, Baumann, T., Mroginski, Maria-Andrea, Kubyshkin, V., Kubyshkin, Vladimir, Mroginski, Maria Andrea   +18 more
core   +1 more source

Halogenation Strategies In Natural Product Biosynthesis [PDF]

, 2008
Halogenation is a frequent modification of secondary metabolites and can play a significant role in establishing the bioactivity of a compound. Enzymatic halogenation through oxidative mechanisms is the most common route to these metabolites, though ...
Fujimori, Danica Galonić, Neumann, Christopher S., Walsh, Christopher T.   +2 more
core   +1 more source

C─S Bond Formation of Aryl Germanes

Angewandte Chemie, EarlyView.
Site‐selective C─S bond formation of aryl germanes, even in the presences of other functional groups such as silane or boron derivatives, is described. The protocol operates under metal‐free conditions at room temperature without the need of inert atmosphere.
Jaime Ponce‐de‐León, Markus D. Schoetz, Amit Dahiya, Susanna L. Kirsten, Kristina Deckers, Steffen Benkhoff, Franziska Schoenebeck   +6 more
wiley   +2 more sources

Oxidative halogenation enabled by 2-haloethanol and aqueous H2O2 under metal-free conditions

Green Synthesis and Catalysis
Electrophilic halogenation reactions have been recognized as robust approaches to accessing synthetically useful organohalides. Herein, we disclose an exclusive oxidative halogenation pathway, which highlights the use of 2-haloethanol (X ​= ​Cl, Br, I ...
Jingran Zhang, Haofeng Shi, Dongke Zhang, Jiaxin He, Yuli Sun, Fengxia Sun, Yunfei Du   +6 more
doaj   +1 more source

Flavin Catalysts in Organic Synthesis

Angewandte Chemie, EarlyView.
Flavins and their congeners are potent catalysts for organic synthesis inspired by enzymatic transformations. In addition to catalysis in the flavin ground state via covalent intermediates, the excited singlet and triplet states unlock applications including photooxidation, photoreduction, and energy transfer via sensitization.
Jan Freudenberg, Golo Storch
wiley   +2 more sources

Deprotonation and Alkylation of Weakly Acidic C(sp3)─H Bonds Through In Situ Generation of a Strong Hydride Base From 1,1,3,3‐Tetramethyldisiloxane and Potassium tert‐Butoxide

Angewandte Chemie, EarlyView.
The use of 1,1,3,3‐tetramethyldisiloxane (TMDSO) and potassium tert‐butoxide enables direct alkylation of weakly acidic carbon–hydrogen bonds with alkyl halides. Experimental and computational studies support the formation of a substrate‐associated hydride‐like base, providing a single‐step alternative to the classical deprotonation and electrophile ...
Piers St. Onge, Brandon White, Han Yao, Travis Dudding, Stephen G. Newman   +4 more
wiley   +2 more sources

Iron-Promoted Cyclization/Halogenation of Alkynyl Diethyl Acetals

, 2009
FeCl(3)(-) and FeBr(3)-promoted cyclization/halogenation of alkynyl diethyl acetals has been efficiently realized, selectively affording (E)-2(1-halobenzylidene or alkylidene)-substituted five-membered carbo- and heterocycles which were then efficiently ...
Xu, Tongyu, Wang, Liandi, Yu, Zhengkun, 余正坤   +3 more
core   +1 more source

1,4‐Brook Rearrangement of β‐Silyl Allylic Alcohols: Trisubstituted Alkenes by Copper‐Mediated Stereoretentive ipso‐Substitution Reactions

Angewandte Chemie, EarlyView.
To fully leverage the power of the ruthenium‐catalyzed trans‐hydrosilylation of propargyl alcohols, it was necessary to develop a practical and robust method for the activation of those products that carry the silyl group distal to the hydroxy substituent.
Paul Haf‐Moths, Jack L. Sutro, Alois Fürstner   +2 more
wiley   +2 more sources

1,2‐Bis(boronate) Arenes by Borylation Directed Borylation

Angewandte Chemie, EarlyView.
Boron electrophiles derived from tetrabromo‐pyrazaboles and AlCl3 affect the regioselective vicinal double C–H borylation of a range of arenes and polycyclic aromatic hydrocarbons (PAHs). A subsequent pinacol installation step then affords the vicinal bis‐boronate ester‐substituted arene/PAH.
Anna V. Schellbach, Mathew J. Cross, Emily Noone, Cate S. Anstöter, Michael J. Ingleson   +4 more
wiley   +2 more sources

Azobenzene's Cross‐Scale Optics and Photonics: Molecular Photoswitching, Mesoscopic Material Motions, and Adaptive Devices

Advanced Materials, EarlyView.
Azobenzene photoswitches translate molecular‐scale E/Z photoisomerization into macroscopic material responses and device‐level photonic functions. This Review highlights how azobenzene research has evolved from molecular photochemistry to photoalignment, mass migration, photomechanics, and heat release, ultimately enabling holography, reconfigurable ...
Heeju Son, Soyul Kwak, Heerin Noh, Minsang Kim, Doyeon Noh, Subhayan Chakraborty, Jaewon Lee, YongDeok Cho, Kyeongsoo Kim, Taewoong Eom, Moonyoung Kim, Jangwon Kim, Hoyoung Lee, Soyoung Lee, Jaehun Kim, Grace G. D. Han, Shin‐Tson Wu, Stefano Oscurato, Arri Priimagi, Marina Saphiannikova, Seungwoo Lee   +20 more
wiley   +1 more source