Results 41 to 50 of about 11,578 (241)

Further Characterization of Fungal Halogenase RadH and Its Homologs

Biomolecules, 2023
RadH is one of the flavin-dependent halogenases that has previously exhibited promising catalytic activity towards hydroxycoumarin, hydroxyisoquinoline, and phenolic derivatives.
GuangRong Peh, Gregory A. Gunawan, Terence Tay, Elaine Tiong, Lee Ling Tan, Shimin Jiang, Yi Ling Goh, Suming Ye, Joel Wong, Christopher J. Brown, Huimin Zhao, Ee Lui Ang, Fong Tian Wong, Yee Hwee Lim   +13 more
doaj   +1 more source

In Silico and Experimental Investigation of the Biological Potential of Some Recently Developed Carprofen Derivatives

Molecules, 2022
The efficient regioselective bromination and iodination of the nonsteroidal anti-inflammatory drug (NSAID) carprofen were achieved by using bromine and iodine monochloride in glacial acetic acid.
Florea Dumitrascu, Ana-Maria Udrea, Mino R. Caira, Diana Camelia Nuta, Carmen Limban, Mariana Carmen Chifiriuc, Marcela Popa, Coralia Bleotu, Anamaria Hanganu, Denisa Dumitrescu, Speranta Avram   +10 more
doaj   +1 more source

Selective Halogenation of Pyridines Using Designed Phosphine Reagents

, 2019
Halopyridines are key building blocks for synthesizing pharmaceuticals, agrochemicals, and ligands for metal complexes, but strategies to selectively halogenate pyridine C–H precursors are lacking.
Andrew, McNally, Jeffrey N., Levy, Ren-Rong, Liu   +2 more
core   +1 more source

Cryptic Halogenation Reactions in Natural Product Biosynthesis [PDF]

, 2021
Enzymatic halogenation reactions are essential for the production of thousands of halogenated natural products. However, in recent years, scientists discovered several halogenases that transiently incorporate halogen atoms in intermediate biosynthetic ...
Adak, Sanjoy, Moore, Bradley S., Moore, Bradley S   +2 more
core   +1 more source

Iron-Promoted Cyclization/Halogenation of Alkynyl Diethyl Acetals

, 2009
FeCl(3)(-) and FeBr(3)-promoted cyclization/halogenation of alkynyl diethyl acetals has been efficiently realized, selectively affording (E)-2(1-halobenzylidene or alkylidene)-substituted five-membered carbo- and heterocycles which were then efficiently ...
Xu, Tongyu, Wang, Liandi, Yu, Zhengkun, 余正坤   +3 more
core   +1 more source

Heterogeneous photocatalytic recycling of FeX2/FeX3 for efficient halogenation of C−H bonds using NaX [PDF]

, 2023
Environmental-friendly halogenation of C−H bonds using abundant, non-toxic halogen salts is in high demand in various chemical industries, yet the efficiency and selectivity of laboratory available protocols are far behind the conventional photolytic ...
Richards, Emma, Jiani Ye, Federico Rosei, Su, Ren, Salli, Sofia, Emma Richards, Niemantsverdriet, Hans, Yang, Yong, Dongsheng Zhang, Rosei, Federico, Li, Yajiao, Flemming Besenbacher, Yongwang Li, Ren Su, Sofia Salli, Feiyu Han, Ye, Jiani, Li, Yongwang, Yajiao Li, Besenbacher, Flemming, Han, Feiyu, Mai, Yuanqiang, Zhang, Dongsheng, Yong Yang, Hans Niemantsverdriet, Yuanqiang Mai   +25 more
core   +1 more source

A Kinetic–Energetic Bottleneck of Charge‐Transfer Injection Governs Energy Loss in Organic Solar Cells

Advanced Energy Materials, EarlyView.
Kinetic–energetic projection of time‐resolved photoluminescence reveals that charge‐transfer injection acts as a universal bottleneck in organic solar cells. A physics‐constrained Bayesian framework identifies an emergent effective CT injection rate governing the trade‐off between charge generation and nonradiative energy loss.
Rong Wang, Tobias Osterrieder, Atul Shukla, Christos L. Chochos, Vasilis G. Gregoriou, Yakun He, Hua Tang, Julian Matthias Haffner‐Schirmer, Karen Forberich, Ning Li, Thomas Heumueller, Frédéric Laquai, Jens Hauch, Safa Shoaee, Dieter Neher, Larry Lüer, Christoph J. Brabec   +16 more
wiley   +1 more source

Two-Component FAD-Dependent Monooxygenases: Current Knowledge and Biotechnological Opportunities

Biology, 2018
Flavoprotein monooxygenases create valuable compounds that are of high interest for the chemical, pharmaceutical, and agrochemical industries, among others. Monooxygenases that use flavin as cofactor are either single- or two-component systems.
Thomas Heine, Willem J. H. van Berkel, George Gassner, Karl-Heinz van Pée, Dirk Tischler   +4 more
doaj   +1 more source

Catalytic, Asymmetric α-Halogenation

, 2016
Catalytic, Asymmetric α ...
Ahmed M. Hafez (2714233), Harald Wack (2694217), Andrew E. Taggi (2520316), William J. Drury (2101174), Thomas Lectka (1357518)   +4 more
core   +1 more source

Site-selective chlorination of pyrrolic heterocycles by flavin dependent enzyme PrnC

Communications Chemistry
Halogenation of pyrrole requires strong electrophilic reagents and often leads to undesired polyhalogenated products. Biocatalytic halogenation is a highly attractive approach given its chemoselectivity and benign reaction conditions.
GuangRong Peh, Terence Tay, Lee Ling Tan, Elaine Tiong, Jiawu Bi, Yi Ling Goh, Suming Ye, Fu Lin, Cheryl Jia Xin Tan, Yong Zi Tan, Joel Wong, Huimin Zhao, Fong Tian Wong, Ee Lui Ang, Yee Hwee Lim   +14 more
doaj   +1 more source