Results 21 to 30 of about 11,578 (241)
Molecules, 2022 Prodigiosins (prodiginines) are a class of bacterial secondary metabolites with remarkable biological activities and color. In this study, optimized production, purification, and characterization of prodigiosin (PG) from easily accessible Serratia ...
Jelena Lazic +8 more
doaj +1 more source
Decarboxylative Halogenation of Indoles by Vanadium Haloperoxidases
, 2023 Halogenated heteroarenes are key building blocks across numerous chemical industries. Here, we report that vanadium haloperoxidases are capable of producing 3-haloindoles through decarboxylative halogenation of 3-carboxyindoles.
Lauren P.T., Ramos +6 more
core +1 more source
Halogenation of tyrosine perturbs large-scale protein self-organization [PDF]
, 2022 Protein halogenation is a common non-enzymatic post-translational modification contributing to aging, oxidative stress-related diseases and cancer. Here, we report a genetically encodable halogenation of tyrosine residues in a reconstituted prokaryotic ...
Kendall, O. +18 more
core +2 more sources
Introducing N-X Anomeric Amides: Powerful Electrophilic Halogenation Reagents
, 2023 Electrophilic halogenation is a widely-used tool employed by medicinal chemists to either pre-functionalize molecules for further diversity or incorporate a halogen atom in drugs or drug-like compounds to solve metabolic problems or modulate off-target ...
Doris, Chen +16 more
core +1 more source
Technical Note: Reactivity of C1 and C2 organohalogens formation – from plant litter to bacteria [PDF]
Biogeosciences, 2012 C1/C2 organohalogens (organohalogens with one or two carbon atoms) can have significant environmental toxicity and ecological impact, such as carcinogenesis, ozone depletion and global warming.
J. J. Wang +6 more
doaj +1 more source
Synthesis and Reactions of 3-Halogenated 2-CF3-Indoles
Molecules, 2022 Halogenation of 2-trifluoromethylindole afforded 3-chloro-, 3-bromo- and 3-iodo derivatives in up to 98% yield. Methyl-, benzyl- and tosyl-groups can be installed at the nitrogen atom of prepared indoles in high yields by base catalyzed reaction with the
Vasiliy M. Muzalevskiy +2 more
doaj +1 more source
Intramolecular halogen–halogen bonds?
Physical Chemistry Chemical Physics, 2013 By analysing the properties of the electron density in the structurally simple perhalogenated ethanes, X3C-CY3 (X, Y = F, Cl), a previously overlooked non-covalent attraction between halogens attached to opposite carbon atoms is found. Quantum chemical calculations extrapolated towards the full solution of the Schrödinger equation reveal the complex ...
Johansson, Mikael P., Swart, Marcel
openaire +5 more sources
Halogenation as a Strategy to Improve Antiplasmodial Activity: A Report of New 3-Alkylpyridine Marine Alkaloid Analogs [PDF]
International Journal of Travel Medicine and Global Health, 2019 Introduction: Due to the emergence of resistance to antimalarial drugs as well as the lack of vaccination for malaria, there is an urgent demand for the development of new antimalarial alternatives.
Camila Barbosa +6 more
doaj +1 more source
Role of a secondary coordination sphere residue in halogenation catalysis of non-heme iron enzymes
, 2022 Chemo- and regio-selective catalysis of C(sp3)-H halogenation reaction is a formidable goal in chemical synthesis. 2-oxo-glutarate (2OG) dependent non-heme iron halogenases catalyze selective chlorination/bromination of C-H bonds and exhibit high ...
Sourav, Chatterjee +4 more
core +1 more source
Molecules, 2021 A series of halogenated 1,5-diarylimidazole compounds were synthesized and their inhibitory effects on LPS-induced PGE2 production in RAW 264.7 cells were evaluated.
Zunhua Yang +4 more
doaj +1 more source