Results 111 to 120 of about 698,678 (191)

Single-Ion Imaging Native Mass Spectrometry: Unraveling the Structural Features and Dissociation Energetics of Macromolecular Assemblies. [PDF]

J Am Soc Mass Spectrom
Mathew A, Mendes Godinho da Silva Veloso L, Giskes F, Eijkel GB, Papanastasiou D, Heck AJR, Makarov AA, Ellis SR, Heeren RMA.   +8 more
europepmc   +1 more source

A Multistrategy AI‐Assisted Consensus Screening Pipeline for Discovery of Candidate p53 Monomer Binders

Advanced Intelligent Discovery, EarlyView.
An ultra‐fast small‐sample AI consensus pipeline combines co‐folding and docking to target structure‐lacking p53 monomers. Its optimal mini‐protein binder shows robust interfacial affinity and promising druggability, supplying unprecedented antitumor p53 templates.
Ningyao Li, Xueyi Liu, Qiuyue Li, Chengfeng Yue, Xin Li, Yugang Huang, Xin Deng, Junfei Zhang, Xue Liang, Guodong Ye   +9 more
wiley   +1 more source

Structural quality-tier assessment for TCR-pMHC functional enrichment. [PDF]

Front Immunol
Ascunce-París A, Romero-Durana M, Valencia A, Farriol-Duran R, Guallar V.   +4 more
europepmc   +1 more source

Astrocyte SMN Restoration and Forskolin Treatment Improve SMA Synaptic Pathology

Annals of Neurology, EarlyView.
Objective Early phenotypic presentation of central afferent synapse dysfunction within patients with spinal muscular atrophy (SMA) represents a key target for therapeutic development; however, the underlying disease mechanisms remain unresolved. By further investigating motor neuron synapse and peri‐synaptic astrocyte process (PAP) defects in human SMA
Emily Welby, Xiaojie Liu, Melinda Wojtkiewicz, Linda Berg Luecke, Rebekah L. Gundry, Qing‐Song Liu, Allison D. Ebert   +6 more
wiley   +1 more source

Correction: miR-1260b, mediated by YY1, activates KIT signaling by targeting SOCS6 to regulate cell proliferation and apoptosis in NSCLC. [PDF]

Cell Death Dis
Xia Y, Wei K, Yang FM, Hu LQ, Pan CF, Pan XL, Wu WB, Wang J, Wen W, He ZC, Xu J, Xu XF, Zhu Q, Chen L.   +13 more
europepmc   +1 more source

Найкращі білінійні наближення класів $ $ В_ {{p,\theta}}^{\varOmega}$ $ періодичних функцій багатьох змінних

, 2011
Одержано точні за порядком оцінки найкращих білінійних наближень класів $B^{\Omega}_{p,\theta}$ періодичних функцій $2d$ змінних у просторі $L_{q}$ лінійними комбінаціями добутків функцій $d$ змінних.
Solich, Kateryna, Соліч, Катерина   +1 more
core  

Minimising mutation load as a mechanism for low-dose hyper-radiosensitivity and induced radioresistance. [PDF]

Sci Rep
Polgár S, Madas BG.
europepmc   +1 more source

Comparative analysis of molecular targeted radiosensitizers in 2D and 3D cancer cell line models. [PDF]

Acta Oncol
Ramirez Parra M, Dietrich A, Pfeifer M, Willers H, Krause M, Borgeaud N.   +5 more
europepmc   +1 more source

LncRSFD Alternative Splicing Modulates the Proliferation and Differentiation of Adipocytes Through Sponging miRNAs

Animal Research and One Health, EarlyView.
This study identified a molecule named lncRSFD, which is highly expressed in sheep adipose tissues. The lncRSFD gene generates two distinct transcript variants via alternative splicing: lncRSFD‐L and lncRSFD‐S. Functionally, lncRSFD alternative splicing (lncRSFD‐L/S) promotes the proliferation, differentiation, and lipid metabolism of adipocytes ...
Jinpeng Wang, Qiuyang Li, Zhiying Wang, Shan Zhang, Kassahun Bekana, Qingfeng Zhang, Juanshan Zheng, Hongwei Xu, Xianyong Lan, Chuanying Pan   +9 more
wiley   +1 more source

Liquiritin restores metabolic homeostasis in NAFLD by modulating AKT1/FOXO1 signaling. [PDF]

Front Pharmacol
Zhang Z, Jiao S, Jiang T, Zhang R, Sun Z, Zhang Z, Pan Y, Guo J.   +7 more
europepmc   +1 more source