Results 201 to 210 of about 5,167,336 (292)

A Decoy‐Receptor‐Armed Biomimetic Nanotherapeutic With Inherent Tropism for Conserved Pathogenic Macrophages for Treating Osteoarthritis and Intervertebral Disc Degeneration

Advanced Science, EarlyView.
A biomimetic doppelgänger nanosystem neutralizes extracellular inflammatory cytokines and silences intracellular pyroptosis, reprogramming pathogenic macrophages to attenuate both joint and spine degeneration. ABSTRACT Osteoarthritis (OA) and intervertebral disc degeneration (IVDD) are debilitating musculoskeletal disorders driven by shared ...
Fudong Li, Bin Zhang, Zhiqiu Zhang, Bing Zheng, Linhui Han, Chen Yan, Jialin Li, Kaiqiang Sun, Tianyi Zhao, Jiangang Shi   +9 more
wiley   +1 more source

SpotMAX: A generalist framework for multidimensional automatic spot detection and quantification. [PDF]

Sci Adv
Padovani F, Čavka I, Neves ARR, López CP, Al-Refaie N, Bolcato L, Chatzitheodoridou D, Chadha Y, Lagos P, Stegmaier T, Su XA, Lengefeld J, Cabianca DS, Köhler S, Schmoller KM.   +14 more
europepmc   +1 more source

Carrier‐Free Berberine/Nitidine Chloride Self‐Assembled Nanoparticles Induce Ferroptosis to Overcome Bortezomib Resistance in Multiple Myeloma

Advanced Science, EarlyView.
A schematic illustrating the fabrication process and ferroptosis‐mediated therapeutic mechanism of carrier‐free self‐assembled BBR/NC‐SAPs for overcoming bortezomib resistance in multiple myeloma. ABSTRACT Therapeutic relapse driven by bortezomib resistance represents a formidable clinical barrier in the management of multiple myeloma (MM).
Yiwen Lv, Shuang Liu, Hong Wu, Guiluan Li, Ying Rong, Guangchao Li, Yangmin Zhu, Qi Zhong, Ruiming Ou, Huijuan Shen, Zhi Liu, Jing Huang, Zhenwei Wang, Pei Lin, Qing Zhang, Guopan Yu, Zhao Yin   +16 more
wiley   +1 more source

Hydrogel Phase Transition-Driven Soft Gating Circumvents Debye Screening for Advanced Biosensing. [PDF]

Adv Sci (Weinh)
Shi L, Zhang Z, Li B, Gao Y, Zhang R, Mu Z, Ni J, Bo B, Li G.   +8 more
europepmc   +1 more source

The CXCL5/CXCR2 Axis Attenuates Ferroptosis in Intrahepatic Cholangiocarcinoma Through the Positive Feedback Loop Between PTGS2 Transcriptional Activation and Neutrophil Recruitment

Advanced Science, EarlyView.
The CXCL5/CXCR2 axis directly inhibits ferroptosis in ICC cells by activating the NF‐κB/PTGS2 pathway. Meanwhile, the CXCL5/CXCR2 axis recruits N2 TANs, and the activated PTGS2 promotes the secretion of TNF‐α from the recruited N2 TANs via the CCL2/CCL7/CCR2 pathway, thereby activating the NF‐κB/PTGS2 axis and forming a positive feedback loop, which ...
Chanqi Ye, Kefeng Lin, Shuyao Yang, Yan Zhang, Wenli Gao, Jiaqi Chen, Ying Dong, Rui Bai, Yang Tian, Minghao Wang, Zhijun Yuan, Yuxiao Ma, Yuqin He, Ruyin Chen, Wenguang Fu, Qi Jiang, Qiong Li, Jian Ruan   +17 more
wiley   +1 more source

Statement of Retraction: STAT3-induced upregulation of long noncoding RNA HNF1A-AS1 promotes the progression of oral squamous cell carcinoma via activating Notch signaling pathway. [PDF]

Cancer Biol Ther
europepmc   +1 more source

Influence of semiconductive shielding protrusions on the electric field distribution in ±500 kV HVDC cables. [PDF]

PLoS One
Xu H, Wang W, Lu Y, Shi H, Zhao Z, Tang C, Lyu G, Cao L.   +7 more
europepmc   +1 more source

Iron‐Tannic Acid Hydrogel Mediated Mild Photothermal Therapy Combined With Ferroptosis Enhances Anti‐Tumor Immunity in Colorectal Cancer

Advanced Science, EarlyView.
An injectable gelatin‐based tannic acid–iron hydrogel with mild photothermal therapy could not only induce immunogenic cell death, but also elicit ferroptosis of both tumor cells and tumor‐associated macrophages, resulting in DC maturation, T‐cell infiltration and down‐regulation of ferroptosis‐sensitive M2‐type TAMs levels.
Yuan Zhu, Xi Yu, Tao Wang, Wanyi Liu, Chang Lu, Jiani Zhong, Yujie He, Wei Li, Kunxi Zhang, Peihao Yin, Zeting Yuan   +10 more
wiley   +1 more source

Statement of Retraction: MicroRNA-146 attenuates lipopolysaccharide induced ovarian dysfunction by inhibiting the TLR4/NF- κB signaling pathway. [PDF]

Bioengineered
europepmc   +1 more source

A Cytosine‑Bulged (3+1) Hybrid G‑Quadruplex Formed by the Chicken DNA Replication Origin. [PDF]

Chemistry
You Y, Suen MC, Miao H, Geng Y, Din RU, Yuan M, Xue Q, Li X, Xu N, Guo Z, Lam HM, Lo KW, Liu C, Zhu G.   +13 more
europepmc   +1 more source