Results 151 to 160 of about 1,083,982 (306)

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

2D-Materials: Synthesis and Investigation of Electrical and Thermal Properties

, 2018
This dissertation presents a study of (1) the growth of in-plane MoS2-graphene heterostructure together with its electrical characterizations, (2) the power dissipation of the WSe2 FET as a representative of 2D-material FETs (Field effect transistors ...
Amirhossein Behranginia (1420744)
core   +1 more source

Author Correction: Valley-filling instability and critical magnetic field for interaction-enhanced Zeeman response in doped WSe2 monolayers

npj Computational Materials, 2022
Fengyuan Xuan, Su Ying Quek
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Tailoring electronic and optical properties of hBN/InTe and hBN/GaTe heterostructures through biaxial strain engineering

Scientific Reports
In this research study, we systematically investigate the electronic and optical properties of van der Waals heterostructures (HSs) consisting of InTe (GaTe) and hBN monolayers, subjected to controlled biaxial strain.
A. Šolajić, J. Pešić
doaj   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

2D Frameworks of C2N and C3N as New Anode Materials for Lithium-Ion Batteries

, 2017
Novel layered 2D frameworks (C3N and C2N-450) with well-defined crystal structures are explored for use as anode materials in lithium-ion batteries (LIBs) for the first time.
Liming Dai, Jong‐Beom Baek, Xu, Jian, Yuhai Dou, Li, Feng, Xu, Jiantie, Baek, Jong-Beom, Jiantie Xu, Feng Li, Dou, Shixue, Mahmood, Javeed, Dou, Yuhai, Shixue Dou, Dai, Liming, Javeed Mahmood   +14 more
core   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Introduction to 2D materials and their applications

RSC Advances
Diana Berman, Agnieszka Jastrzebska, Massimiliano Papi, and Andreas Rosenkranz introduce the RSC Advances themed issue on 2D materials and their applications.
Diana Berman, Agnieszka Jastrzebska, Massimiliano Papi, Andreas Rosenkranz   +3 more
openaire   +3 more sources