Results 31 to 40 of about 285,502 (248)

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

The Impacts of Assimilating Fengyun-4A Atmospheric Motion Vectors on Typhoon Forecasts

Atmosphere, 2023
Atmospheric motion vectors (AMVs), known as cloud track winds, have positive impacts on global numerical weather forecasts (NWP). In this study, AMVs that were retrieved from Fengyun-2G and Fengyun-4A were compared in their data quality and impacts on ...
Keyi Chen, Peigen Guan
doaj   +1 more source

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

Molecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard, Sarmad Mehmood, Eva Boysen Fynboe Ebert, Peter Meldgaard, Anindya Dutta, Boe S. Sorensen   +5 more
wiley   +1 more source

The effect of different early feeding regimens involving a hydrated nutritious gel on productive performance, immune variables, and intestinal morphology of broiler chickens

Italian Journal of Animal Science, 2022
The present research aimed to evaluate the effect of early feeding (EF) with a hydrated nutritious gel (HNG) on productive performance, carcass traits, immune variables, and intestinal morphology of broiler chickens.
Alireza Hesabi Nameghi, Ali Nasari Nejad, Marzieh Afkhami, Farhad Khaligh, Omid Behrouzi Nasab   +4 more
doaj   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Awareness of pregnant women about proper nutrition habits and rational diet

Journal of Education, Health and Sport, 2023
Introduction Proper nutrition of a woman before conception and during pregnancy determines the proper course of pregnancy, fetal development and the health of the mother and child in the future.
Izabela Mandryk, Izabella Węgrzyn
doaj   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Диференційований підхід до лікування хронічних ран на основі генетичних досліджень

Український журнал військової медицини
Мета. Дослідити деякі патогенетичні механізми ранового процесу при хронічних ранах, їх асоціативні зв’язки з варіантами поліморфізму 1G/2G-1607 гена ММР-1 та розробити диференційовану тактику лікування таких пацієнтів.
I. Yu. Polianskyi, I. M. Melnyk
doaj   +1 more source

EAA FlightLink 2G

Proceedings of the Wisconsin Space Conference, 2012
Founded over half a century ago in Milwaukee, WI, by a pro-active group of aviators interested in building their own aircraft, the Experimental Aircraft Association (EAA) has subsequently expanded its mission to include the history, preservation, display, and ongoing research on antiques, classics, warbirds, aerobatic aircraft, ultralights, helicopters,
openaire   +1 more source