Results 81 to 90 of about 771,527 (271)
Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum
FEBS Open Bio, EarlyView.Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik +6 more
wiley +1 more source
Journal of Materials Research and TechnologyCurrent-voltage measurement (I–V curve) is a typical method to identify the critical current (Ic) of second-generation high-temperature superconducting tapes (2G HTS tapes).
Chia-Ming Yang +3 more
doaj +1 more source
The impact of three thioxothiazolidin compounds on trehalase activity and development of Spodoptera frugiperda larvae [PDF]
PeerJTrehalases (TREs), serving as crucial enzymes regulating trehalose and chitin metabolism in insects, represent prime targets for pest control strategies.
Yan Wu +10 more
doaj +2 more sources
YIPFα1A expression is regulated by multilayered molecular mechanisms
FEBS Open Bio, EarlyView.YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji +2 more
wiley +1 more source
On the top homology group of Johnson kernel
, 2019 The action of the mapping class group $\mathrm{Mod}_g$ of an oriented surface $\Sigma_g$ on the lower central series of $\pi_1(\Sigma_g)$ defines the descending filtration in $\mathrm{Mod}_g$ called the Johnson filtration.
Gaifullin, Alexander A.
core
FEBS Open Bio, EarlyView.Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero +5 more
wiley +1 more source
Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment
Aging and Cancer, EarlyView.Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey +12 more
wiley +1 more source
Evaluation of Intracellular Signaling Downstream Chimeric Antigen Receptors.
PLoS ONE, 2015 CD19-targeting CAR T cells have shown potency in clinical trials targeting B cell leukemia. Although mainly second generation (2G) CARs carrying CD28 or 4-1BB have been investigated in patients, preclinical studies suggest that third generation (3G) CARs
Hannah Karlsson +7 more
doaj +1 more source
The period matrix of the hyperelliptic curve $w^2=z^{2g+1}-1$ [PDF]
, 2014 A geometric algorithm is introduced for finding a symplectic basis of the first integral homology group of a compact Riemann surface, which is a $p$-cyclic covering of ${\mathbb C} P^1$ branched over 3 points.
Tadokoro, Yuuki
core +2 more sources
Annals of Clinical and Translational Neurology, EarlyView.Epigenetic reprogramming in hematopoietic stem and progenitor cells (HSPCs) and downstream myeloid cells, mediated by H3.3 downregulation and endogenous retroelement (ERE) overexpression, contributes to the progression of multiple sclerosis (MS). ABSTRACT Background Skewed myelopoiesis in the bone marrow has been identified as a key driver of multiple ...
Li‐Mei Xiao +6 more
wiley +1 more source