Results 61 to 70 of about 771,527 (271)

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Phase Angle Is Related with Visceral Obesity in Young Adults

Obesities
Obesity is a global problem, increasing interest in adipose tissue (AT) biology. One of the techniques for analyzing visceral adipose tissue (VAT) and phase angle (PhA) is bioelectrical impedance analysis (BIA).
Izabela Mandryk, Joanna Bonior, Magdalena Koszarska   +2 more
doaj   +1 more source

Extensive study on the pharmaceutical constituents of leaf and root of Costus after (ker) [PDF]

Journal of Chemistry Letters
An extensive investigation has been carried out on Costus afer (ker) plant leaves and roots so as to ascertain its secondary metabolites. The qualitative phytochemical assay indicated the presence of tannins, saponins, steroids, terpenoids, alkaloids ...
Ozioma Anekwe-Nwekeaku, Ebele Morah, Obiajulu Ezeigwe, Emeka Ezeudu, Amalachukwu Obi, Njideka Nwankwo   +5 more
doaj   +1 more source

Circular dichroism of magneto-phonon resonance in doped graphene

, 2012
Polarization resolved, Raman scattering response due to E$_{2g}$ phonon in monolayer graphene has been investigated in magnetic fields up to 29 T. The hybridization of the E$_{2g}$ phonon with only the fundamental inter Landau level excitation (involving
Dujardin, E., Faugeras, C., Geim, A. K., Kossacki, P., Kühne, M., Mahmood, A., Nair, R. R., Orlita, M., Potemski, M.   +8 more
core   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

The Influence of MMP-1 rs1799750 Gene Variant on the Severity of Open Bite Malocclusion

Applied Sciences
In this study, the association of MMP-1 rs1799750 gene polymorphism, which plays an important role in collagen degradation, with open bite malocclusion was investigated.
Özlem Özge Yılmaz, Tolga Polat, Elvan Önem Özbilen, Beste Tacal Aslan   +3 more
doaj   +1 more source

Techno-economic evaluation of 2^nd generation bioethanol production from sugar cane bagasse and leaves integrated with the sugar-based ethanol process

Biotechnology for Biofuels, 2012
Background Bioethanol produced from the lignocellulosic fractions of sugar cane (bagasse and leaves), i.e. second generation (2G) bioethanol, has a promising market potential as an automotive fuel; however, the process is still under investigation on ...
Macrelli Stefano, Mogensen Johan, Zacchi Guido   +2 more
doaj   +1 more source

Privat 2G, im Dienst 3G?

, 2021
Verfassungsblog: On Matters ...
openaire   +2 more sources