Results 41 to 50 of about 1,013 (159)
Brain and Behavior, Volume 15, Issue 9, September 2025.Schematic diagram. Low KLF7 expression after IS further impairs transcriptional repression of MKNK2, which exacerbates MCAO/R‐induced pathological injury in mice by activating the HIF‐1 pathway‐mediated pro‐inflammatory M1 polarization of microglia. ABSTRACT Background Ischemic stroke (IS) is a common neurological disease with a significant financial ...
Ran Wei, Shuang Li, Lei Tang
wiley +1 more source
ENERGY &ENVIRONMENTAL MATERIALS, Volume 8, Issue 5, September 2025.This review involves a comprehensive study on the diverse applications of the magnetic layered double hydroxides (LDHs) including their catalytic performances, as well as, environmental and biological functions. Moreover, different strategies utilized for the synthesis of LDH‐based composites are described.
Mohammad Mavvaji +2 more
wiley +1 more source
Deacylative Reactions: Synthetic Applications [PDF]
, 2018 Herein we introduce the recent developments of a new strategy based on deacylative alkylation (DaA) reactions for the generation of quaternary stereocenters based on the in situ preparation and functionalization of enolates under very mild reaction ...
Molina, Cynthia +4 more
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Advances in Ligand‐Driven Pd‐Catalyzed C─H Functionalizations: Recent Insights and Updates
ChemCatChem, Volume 17, Issue 15, August 7, 2025.The most significant advances in ligand‐driven Pd‐catalyzed organic synthesis over the past two years are presented. Processes involving C─H activation of substrates, avoiding their prefunctionalization are illustrated. Both the activity and selectivity of the catalyst depend on the design of the ligands (pyridones, pyridines, amino acids, phosphines ...
Jesús Moradell +3 more
wiley +1 more source
3-Alkoxy-1-Benzyl-5-Nitroindazole Derivatives Are Potent Antileishmanial Compounds [PDF]
Indazoles have previously been identified as molecules with antiprotozoal activity. In this study, we evaluate the in vitro activity of thirteen 3-alkoxy-1-benzyl-5-nitroindazole derivatives (series D) against L. amazonensis, L. infantum, and L. mexicana.
Aguirre-García, María Magdalena +11 more
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ChemistryOpen, Volume 14, Issue 8, August 2025.New tellurium‐containing tetrahydropyrazolo[1,2‐a]pyridazines and dihydropyrazolo[1,2‐a]pyrazoles were obtained by electrophilic heterocyclization in the form of intramolecular salts, and optimal conditions for their synthesis were found. The heterocyclization process is regio‐ and stereoselective, which is confirmed by spectral studies, and by X‐ray ...
Marianna V. Povidaichyk +3 more
wiley +1 more source
Multidirectional Synthesis of Substituted Indazoles via Iridium-Catalyzed C–H Borylation [PDF]
, 2015 In the absence of a steric directing group, iridium-catalyzed C–H borylation of N-protected indazoles occurs rapidly and selectively at C-3 and the resulting boronate esters can be utilized in a range of downstream conversions.
Andrew C. Hones +5 more
core +4 more sources
C−H Alkylation of Heterocycles via Light‐Mediated Palladium Catalysis
Angewandte Chemie, Volume 137, Issue 4, January 21, 2025.The photoexcitation of palladium catalysts enables the C−H functionalization of aromatic heterocycles with alkyl halides via a radical strategy. By integrating experimental and computational approaches, we develop a predictive substrate scope and outline generalized synthetic applications. Abstract Methods enabling direct C−H alkylation of heterocycles
Sudip Senapati +5 more
wiley +2 more sources
Metal-catalyzed and aryne-mediated multicomponent approaches to heterocycles [PDF]
, 2012 Over the course of the work described in this dissertation, several novel methodologies have been successfully developed and applied to the synthesis of medicinally-relevant heterocycles, including indoles, benzo[b]furans, 1,2-dihydroisoquinolines, 1H ...
Markina, Nataliya Alexandrovna
core +3 more sources
eAmidation: An Electrochemical Amidation of Aldehydes via the Oxidation of N‐Aryl Hydrazones
Advanced Synthesis &Catalysis, Volume 367, Issue 14, July 29, 2025.The indirect electrochemical oxidation of N‐aryl hydrazones offers an efficient approach to access amides from aldehydes and amines. The AZADO‐mediated reaction enables the selective synthesis of a broad range of valuable amides using readily available aldehydes.
Luke Chen +2 more
wiley +1 more source