Results 31 to 40 of about 92,195 (127)

2‐Aryl‐3‐phenylamino‐4,5‐dihydro‐2H‐benz[g]indazoles with Analgesic Activity.

, 2003
A series of 2-aryl-3-phenylamino-4,5-dihydro-2H-benz[g]indazoles was synthesized and tested for antiarrhythmic, local anaesthetic and analgesic activity.
W. FILIPPELLI, F. MAZZEO, SCHENONE, SILVIA, RANISE, ANGELO, Giuseppe Falcone, G. FALCONE, BRUNO, OLGA, BONDAVALLI, FRANCESCO, Olga Bruno, BRULLO, CHIARA, Silvia Schenone, Annalisa Capuano, Angelo Ranise, Chiara Brullo, Filomena Mazzeo, Francesco Bondavalli, Walter Filippelli, A. CAPUANO   +17 more
core   +1 more source

A palladium-catalyzed domino reaction to access 3-amino-2H-indazoles from hydrazines and 2-halobenzonitriles

, 2020
The development of a novel selective synthesis of 3-amino-2H-indazoles from readily available 2-halobenzonitriles is presented. The reaction proceeds through a domino reaction sequence, consisting of a regioselective palladium-catalyzed coupling of ...
Lindemann, P., Miksche, S., Alsalim, R., Halland, N., Nazaré, M., López-Alberca, M.P., Czechtizky, W.   +6 more
core   +1 more source

Metal‐Organic Framework/Organocatalyst Combinations as Powerful Multicatalytic Systems for Aerobic Oxidations

Angewandte Chemie, Volume 138, Issue 3, 16 January 2026.
A multicatalytic strategy based on the simple combination of metal‐organic frameworks (MOFs) and organocatalysts is able to mediate challenging aerobic oxidation reactions. The use of earth‐abundant MOFs and commercially available (hydro)quinone co‐catalysts greatly simplify the generation of powerful multicatalytic systems, opening the door for the ...
Juan Camilo Arango‐Daza, Mathieu Onillon, Leonie Nork, Kunpot Mopoung, Yuttapoom Puttisong, Miguel A. Rivero‐Crespo   +5 more
wiley   +2 more sources

Monosubstituted N‐Arylhydroxylamine Chemistry: Integrating Contemporary Synthetic Approaches for the Efficient Construction of Diverse Heterocyclic Scaffolds

Chemistry – A European Journal, Volume 32, Issue 26, 11 July 2026.
Monosubstituted N‐arylhydroxylamines represent a unique subclass of hydroxylamines that act as pivotal intermediates in redox transformations and as versatile platforms for further synthetic transformations. They serve as key building blocks in the synthesis of architecturally complex heterocycles and other valuable organic compounds.
Michael G. Kallitsakis, Kyriakos D. Nikopoulos, Ioannis N. Lykakis   +2 more
wiley   +1 more source

Organophosphorus-mediated N-N bond formation: facile access to 3-amino-2H-indazoles

, 2016
A convenient and efficient strategy has been devised to access 3-amino-2H-indazole derivatives in two steps from readily available starting materials.
Nazare, M., Christmann, M., Schoene, J., Bel Abed, H.   +3 more
core   +1 more source

Mechanistic and Reactivity Insights into Diboron‐Mediated NN and NN Bond Scission

European Journal of Organic Chemistry, Volume 29, Issue 25, 4 July 2026.
This review highlights the emerging ability of diboron reagents to cleave both π‐bonded (N=N) and σ‐bonded (N—N) nitrogen–nitrogen linkages, integrating mechanistic understanding with recent synthetic applications. Diboron reagents have emerged as versatile reducing agents capable of transforming a broad range of functional groups through pathways like
Raúl Valderrama‐Callejón, Inés Alonso, M. Belén Cid   +2 more
wiley   +1 more source

Abuse Potential and Neurotoxic Effects of the Synthetic Cannabinoid 4F‐ABUTINACA Self‐Administration in Adult Male Rats

Addiction Biology, Volume 31, Issue 7, July 2026.
4F ABUTINACA maintains stable intravenous self‐administration at low doses in male rats, supporting its high abuse potential. Chronic exposure to 4F‐ABUTINACA induces persistent anxiety‐like behaviors and is associated with region‐specific neurotoxicity in the hippocampus, prefrontal cortex and nucleus accumbens, alongside dysregulation of the BDNF ...
Baobao Shi, Huizhen Liu, Manqing Wu, Yuting Wang, Dan Fu, Lili Wen, Huifen Liu, Peng Xu, Wenhua Zhou, Haitao Wang, Miaojun Lai   +10 more
wiley   +1 more source

Cu/Pd cooperatively catalyzed tandem C–N and C–P bond formation: access to phosphorated 2H-indazoles

, 2017
An unprecedented Cu/Pd cooperatively catalyzed tandem C–N/C–P bond formation reaction for the synthesis of phosphorated 2H-indazoles has been developed.
Aijun Lin, Xuanyi Li, Meng Gu, Weiwei Wei, Hequan Yao   +4 more
core   +1 more source

Cell Voltage-Dependent Structural Dichotomy: Electrochemical C–H Acyloxylation and N‑Acylation of 2H‑Indazoles

, 2023
A simple and efficient electrochemical method that utilizes modulation of the cell voltage to cause structural alterations in 2H-indazole is introduced. This method enables the C-3 acyloxylation of 2H-indazole and promotes the transfer of the acyl group ...
Neetu Kumari, Amanpreet Kaur Jassal (1693756), Ved Prakash Verma, Neetu Kumari (2881895), Dinesh Suwalka (16444174), Kuldeep Singh Bhati, Siddharth Sharma (1424311), Dinesh Suwalka, Kuldeep Singh Bhati (13949800), Amanpreet Kaur Jassal, Siddharth Sharma, Ved Prakash Verma (1828390)   +11 more
core   +2 more sources

Electrophilic Iodination of Heterocyclic Compounds. Recent Advances 2008–2025: Part II

European Journal of Organic Chemistry, Volume 29, Issue 22, 9 June 2026.
Electrophilic iodination using molecular iodine and iodide sources represents an efficient approach for accessing valuable iodinated organic compounds. This review highlights recent advances in the iodination of heterocyclic compounds from 2008 to 2025, emphasizing the role of heteroaryl iodides as important synthetic intermediates for biologically ...
Njomza Ajvazi, Stojan Stavber
wiley   +1 more source