Results 41 to 50 of about 92,195 (127)

Theoretical estimation of the annular tautomerism of indazoles

, 2013
Theoretical calculations at semi-empirical AM1 and density functional B3LYP/6-31G* levels were carried out on 52 NH-indazoles. Although in most cases the 1H-tautomer is the most stable, we found several indazoles for which the 2H-tautomer is more stable ...
Elguero, José, Alkorta, Ibon
core   +1 more source

Synthesis, Cytotoxicity, and ADME Studies of New Compounds Containing Coumarin–Indazole–Triazole Nucleus

ChemistrySelect, Volume 11, Issue 24, 25 June 2026.
In this work, the preparation of new coumarin–indazole–triazole–sulfonamide hybrids via a multistep route has been fine‐tuned. The synthesis involves nitration, reduction, formation of a sulfonamide, alkylation, and CuAAC coupling. The synthesized compounds were screened for antiproliferative activity against MDA‐MB‐231 triple‐negative breast cancer ...
Achraf Hibot, Mümin Alper Erdoğan, Abderrafia Hafid, Mostafa Khouili, Güliz Armagan, Maria Dolors Pujol   +5 more
wiley   +1 more source

A facile synthesis of 2H-indazoles under neat conditions and further transformation into aza-gcarboline alkaloid analogues in a tandem one-pot fashion† [PDF]

, 2014
We have described a facile, microwave-assisted, catalyst-free and solvent-free approach to 2H-indazoles and further developed a robust tandem one-pot metal-free strategy for C–C bond formation at the C-3 position of 2H-indazoles leading to a unique ...
D S, Sharada, N C, Chaitra, Shinde, V, A, Sagar   +3 more
core   +1 more source

Preparation of Polyfunctional Indazoles and Heteroarylazo Compounds Using Highly Functionalized Zinc Reagents

, 2016
Readily available 2-chloromethylarylzinc reagents react with functionalized aryldiazonium tetrafluoroborates providing polyfunctional indazoles. Selective metalations of these 2-aryl-2H-indazoles afford new polycyclic aromatics.
Paul Knochel (1376235), Zhihua Peng (535169), Benjamin Haag (347756)   +2 more
core   +2 more sources

SYNTHESIS AND PHARMACOLOGICAL EVALUATION OF 6-CARBETHOXY-5-(3'-BROMOPHENYL)-3-ARYL-2-CYCLOHEXENONES AND 6-ARYL-4-(3'-BROMOPHENYL)-3-OXO-2,3A,4,5-TETRAHYDRO-2H-INDAZOLES [PDF]

Journal of Sciences, Islamic Republic of Iran, 2002
6-Carbethoxy-5-(3'-bromophenyl)-3-aryl-2-cyclohexenones 2a-j were obtained from the1-Aryl-3-(3'-bromophenyl)-2-propene-1-ones 1a-j by Micheal addition of ethyl acetoacetate, followed by internal Claisen condensation.
doaj  

Inhibitors Targeting SARS‐CoV‐2 Papain‐Like Protease: Screening, Design, Synthesis, and Biological Evaluation

ChemMedChem, Volume 21, Issue 9, 14 May 2026.
In our study, we obtained both non‐covalent and covalent PLpro inhibitors. Additionally, the stable protein‐ligand interactions of the active compound were examined using advanced computational docking and molecular dynamics simulations. The non‐covalent inhibitor 2t showed antiviral activity with an EC50 of 2.89 µM, indicating its potential as a ...
Elena‐Oriana Iuga, Nilu Gone, Mariana Ortiz de Godoy, Gabriel Correa Verissimo, Giovanna de Jesus Agostinetto, Liam Urich, Nadine Krüger, Thales Kronenberger, Rafael Victorio Carvalho Guido, Anthony J. O’Donoghue, Stefan A. Laufer, Thanigaimalai Pillaiyar   +11 more
wiley   +1 more source

Discovery of 4‐Quinazolinone‐Containing Phenylalanine Derivatives as Potent, Resistant‐Tolerant HIV Capsid Inhibitors

MedComm, Volume 7, Issue 5, May 2026.
Novel phenylalanine derivatives were identified as HIV‐1 capsid inhibitors. IC‐2i showed significant anti‐HIV‐1 activity at picomolar concentrations. ABSTRACT The HIV‐1 capsid (CA) is a validated antiviral target that plays critical roles in both the early and late stages of the viral life cycle.
Xujie Zhang, Lin Sun, Laura Walsham, Yuexi Ma, Dang Ding, Mei Wang, Fabao Zhao, Jian Zhang, Zhao Wang, Shujing Xu, Xiangyi Jiang, Yang Zhou, Erik De Clercq, Christophe Pannecouque, Chin‐Ho Chen, David C. Goldstone, Xinyong Liu, Alexej Dick, Peng Zhan   +18 more
wiley   +1 more source

An Asymmetric Aryne‐capture Cascade Process: Tunable and Regiodivergent Synthesis of Chiral 2‐Aminobenzylamines by a Three‐Component Reaction

Advanced Synthesis &Catalysis, Volume 368, Issue 7, 1 April 2026.
This method introduces a first‐in‐class diastereoselective and regiodivergent aryne‐capture cascade three‐component reaction (aryne–aryl amine–sulfinimine) that provides direct, one‐pot access to stereochemically defined 2‐aminobenzylamines. Mechanistic investigations have enabled the identification of conditions that can be tuned to selectively ...
Noah Wright, Nathan R. Halcovitch, Bara Mala, Priscilla Ogunmola, Joseph B. Sweeney, Julien Doulcet   +5 more
wiley   +1 more source

Recent Contributions of Organic Synthesis to Forensic Science

ChemPlusChem, Volume 91, Issue 2, February 2026.
Forensic science is a multidisciplinary field that plays a vital role in providing scientific evidence for criminal investigations. This review highlights advances and opportunities at the interface between organic synthesis and forensic science, with applications in drug identification, forensic toxicology, and latent fingerprint detection and ...
Gustavo dos Santos Martins, Mariana dos Santos Dupim, Rodrigo Garcia Agostinho, Fernanda Gadini Finelli   +3 more
wiley   +1 more source

Synthesis, Antitubercular Activity, and Computational Characterization of Novel Phenylpyrazole‐Isoniazid Derivatives

Advances in Pharmacological and Pharmaceutical Sciences, Volume 2026, Issue 1, 2026.
Six new phenyl‐1H‐pyrazole‐carbaldehyde isonicotinylhydrazone derivatives 1-10 were synthesized and characterized by spectroscopic (FT‐IR, 1H NMR, and 13C NMR) techniques and electrospray ionization–mass spectrometry (ESI–MS). Homonuclear data from 2D‐NMR (1H‐1H NOESY) revealed that 3 and 5 adopt the transE isomeric form.
Fernando Carrasco, Wilfredo Hernández, Juan Z. Dávalos, Jackeline Mosquera, Oscar Chupayo, Nelly Sivipaucar, Jaime Tamayo, Eduardo Carrasco-S, Jorge Coronel, Osvaldo Yañez, William Tiznado, Anjali Chauhan   +11 more
wiley   +1 more source