Results 11 to 20 of about 92,195 (127)

Visible-Light-Driven Decarboxylative Coupling of 2H-Indazoles with α-Keto Acids without Photocatalysts and Oxidants. [PDF]

J Org Chem
An efficient synthesis of functionalized 3-acyl-2H-indazoles via visible-light-induced self-catalyzed energy transfer was developed. This method utilized a self-catalyzed energy transfer process between 2H-indazoles and α-keto acids, offering advantages ...
Niu M, Yang C, Leng M, Cao Q, Li M, Shen Z.   +5 more
europepmc   +6 more sources

Copper-Catalyzed Hydroamination of 2-Alkynylazobenzenes: Synthesis of 3-Alkenyl-2H-Indazoles. [PDF]

J Org Chem
A copper-catalyzed intramolecular synthesis of 3-alkenyl-2H-indazoles from 2-alkynylazobenzenes is described. The reaction proceeds in a single step via C–N bond formation and a subsequent 1,2-hydride shift, affording products in high yields.
Mañas C, Herrero-Bourdieu J, Merino E.
europepmc   +2 more sources

Probing 3-Amino-2H-Azaindazoles as Allosteric Inhibitors of the Protein Tyrosine Phosphatase SHP2. [PDF]

ChemMedChem
A palladium‐catalyzed domino reaction facilitated the discovery and rapid synthesis of selective, potent 3‐amino‐2H‐azaindazole derivatives serving as allosteric inhibitors of SHP2. Structural analysis via co‐crystallography confirmed binding at the allosteric site, thereby stabilizing the autoinhibited SHP2 conformation, qualifying this scaffold as a ...
Amoussa M, Efrém NL, Li F, Guo Z, Roske Y, Frank KJ, Pach S, Wolf CA, Bo F, Lesina M, Kintzel M, Alsalim R, Zeitz V, Csorba N, Radetzki S, Keserű GM, Daumke O, Algül H, Wolber G, Li J, Nazaré M.   +20 more
europepmc   +2 more sources

Davis-Beirut reaction: route to thiazolo-, thiazino-, and thiazepino-2H-indazoles. [PDF]

J Org Chem, 2014
Methods for the construction of thiazolo-, thiazino-, and thiazepino-2H-indazoles from o-nitrobenzaldehydes or o-nitrobenzyl bromides and S-trityl-protected 1°-aminothioalkanes are reported.
Farber KM, Haddadin MJ, Kurth MJ.
europepmc   +2 more sources

Photopromoted Free Radical Silylation of 2‑Aryl‑2H‑indazoles with Silanes

, 2023
Photoinduced silylation of silanes with 2-aryl-2H-indazoles was developed under mild conditions, which could efficiently result in diverse 3-silylated 2H-indazoles with good substrate scopes.
Luping Zheng (389782), Yunfei Tian (477047), Zejiang Li (1776949), Dongyu Guo (4347958), Yuyan Miao (17401503), Lijun Li (406691), Weijun Fu (331703)   +6 more
core   +2 more sources

Structure of NH-benzazoles (1H-benzimidazoles, 1H- and 2H-indazoles, 1H- and 2H-benzotriazoles) [PDF]

, 2014
The structure and properties (crystallography, NMR, theoretical calculations) of the three N-unsubstituted benzazoles (1H-benzimidazoles, 1H- and 2H-indazoles, 1H- and 2H-benzotriazoles) have been reviewed for the period 2000-2012 with some results from ...
Elguero, José, López, C., Alkorta, Ibon, Pérez-Torralba, M., Cabildo, P., Sanz, D., García, M. Ángeles, Claramunt, Rosa M., Santa María, D., Farrán, M. Ángeles, Cornago, P.   +10 more
core   +1 more source

Direct Arylations of 2H-Indazoles On Water

, 2016
The efficient palladium-catalyzed synthesis of a range of substituted 2H-Indazoles via C−H arylation is reported. Reactions are performed on water and provide a direct and mild route toward 2,3-diaryl indazoles of widespread biological ...
Michael F. Greaney (1299891), Stephan A. Ohnmacht (747230), Andrew J. Culshaw (2325298)   +2 more
core   +2 more sources

Photochemical Conversion of Indazoles into Benzimidazoles. [PDF]

Angew Chem Int Ed Engl
Fragment-based drug discovery relies on preparing diverse libraries of advanced building blocks, often incorporating heteroaromatic motifs. Altering the core of heteroaromatics to maximize library diversity typically requires de novo synthesis of each ...
Dos Santos T, Buettner CS, Yildiz DB, Mamone M, Ruffoni A, Leonori D.   +5 more
europepmc   +2 more sources

Davis-Beirut Reaction: A Photochemical Brønsted Acid Catalyzed Route to N-Aryl 2H-Indazoles. [PDF]

Org Lett, 2019
The Davis-Beirut reaction provides access to 2H-indazoles from aromatic nitro compounds. However, N-aryl targets have been traditionally challenging to access due to competitive alternate reaction pathways.
Kraemer N, Li CJ, Zhu JS, Larach JM, Tsui KY, Tantillo DJ, Haddadin MJ, Kurth MJ.   +7 more
europepmc   +2 more sources

Efficient and Regioselective Synthesis of 2-Alkyl-2H-indazoles

, 2016
An efficient and regioselective synthesis of 2-methyl-2H-indazoles and 2-ethyl-2H-indazoles using trimethyloxonium tetrafluoroborate or triethyloxonium hexafluorophosphate is ...
Mui Cheung (1523842), Jeffrey A. Stafford (2235520), Amogh Boloor (2425156)   +2 more
core   +1 more source