Results 1 to 10 of about 22,721 (206)

The Characterization of Escherichia coli CpdB as a Recombinant Protein Reveals that, besides Having the Expected 3´-Nucleotidase and 2´,3´-Cyclic Mononucleotide Phosphodiesterase Activities, It Is Also Active as Cyclic Dinucleotide Phosphodiesterase. [PDF]

PLoS ONE, 2016
Endogenous cyclic diadenylate phosphodiesterase activity was accidentally detected in lysates of Escherichia coli BL21. Since this kind of activity is uncommon in Gram-negative bacteria, its identification was undertaken.
Iralis López-Villamizar, Alicia Cabezas, Rosa María Pinto, José Canales, João Meireles Ribeiro, José Carlos Cameselle, María Jesús Costas   +6 more
doaj   +14 more sources

Discovery of natural CdnP inhibitors through structure-based virtual screening and molecular dynamics simulations [PDF]

Microbiology Spectrum
Tuberculosis, caused by Mycobacterium tuberculosis, remains one of the most lethal infectious diseases both historically and in the post-coronavirus disease 2019 era.
Xiaoxia Gu, Chaohu Xiong, Xinyu Wang, Hucheng Zhu, Weiguang Sun, Yan He, Jinwen Zhang   +6 more
doaj   +2 more sources

C-di-AMP levels modulate Staphylococcus aureus cell wall thickness, response to oxidative stress, and antibiotic resistance and tolerance

Microbiology Spectrum, 2023
Beta-lactam antibiotics are widely used to treat infections caused by the important human pathogen Staphylococcus aureus. Resistance to beta-lactams, as found in methicillin-resistant S. aureus, renders effective treatment difficult. The second messenger
Vanina Dengler Haunreiter, Andrea Tarnutzer, Julian Bär, Manuela von Matt, Sanne Hertegonne, Federica Andreoni, Clément Vulin, Lisa Künzi, Carmen Menzi, Patrick Kiefer, Philipp Christen, Julia A. Vorholt, Annelies S. Zinkernagel   +12 more
doaj   +2 more sources

Assessment of Diadenylate Cyclase and c-di-AMP-phosphodiesterase Activities Using Thin-layer and Ion Exchange Chromatography

Bio-Protocol, 2021
All living cells use cyclic nucleotides as second messengers for signal sensing and transduction. Cyclic di-3′,5′-adenosine monophosphate (c-di-AMP) is primarily involved in the control of bacterial and euryarcheal osmoadaptation and is produced by ...
Andreas Latoscha, David Drexler, Gregor Witte, Natalia Tschowri   +3 more
doaj   +1 more source

Functional Analysis of the Expanded Phosphodiesterase Gene Family in Toxoplasma gondii Tachyzoites

mSphere, 2022
Toxoplasma motility is both activated and suppressed by 3′,5′-cyclic nucleotide signaling. Cyclic GMP (cGMP) signaling through Toxoplasma gondii protein kinase G (TgPKG) activates motility, whereas cyclic AMP (cAMP) signaling through TgPKAc1 inhibits ...
William J. Moss, Caitlyn E. Patterson, Alexander K. Jochmans, Kevin M. Brown   +3 more
doaj   +1 more source

Ectonucleotidases in Acute and Chronic Inflammation

Frontiers in Pharmacology, 2021
Ectonucleotidases are extracellular enzymes with a pivotal role in inflammation that hydrolyse extracellular purine and pyrimidine nucleotides, e.g., ATP, UTP, ADP, UDP, AMP and NAD+. Ectonucleotidases, expressed by virtually all cell types, immune cells
Anna Lisa Giuliani, Alba Clara Sarti, Francesco Di Virgilio   +2 more
doaj   +1 more source

Growth of the marine luminous bacterium Vibrio fischeri on 3':5'-cyclic AMP: correlation with a periplasmic 3':5'-cyclic AMP phosphodiesterase [PDF]

Journal of General Microbiology, 1992
Summary: The marine luminous bacterium Vibrio fischeri, the species-specific light-organ symbiont of monocentrid (pinecone) fish, grew on 3′:5′-cyclic adenosine monophosphate (cAMP) as a sole source of carbon and energy, a capability not previously described in bacteria.
P. V. Dunlap, U. Mueller, T. A. Lisa, K. S. Lundberg   +3 more
openaire   +1 more source

Identification and Localization of the Cyclic Nucleotide Phosphodiesterase 10A in Bovine Testis and Mature Spermatozoa. [PDF]

PLoS ONE, 2016
In mammals, adenosine 3', 5'-cyclic monophosphate (cAMP) is known to play highly important roles in sperm motility and acrosomal exocytosis. It is known to act through protein phosphorylation via PRKA and through the activation of guanine nucleotide ...
Serge Goupil, Loïze Maréchal, Hassan El Hajj, Marie-Ève Tremblay, François J Richard, Pierre Leclerc   +5 more
doaj   +1 more source

Regulation of transsynaptically elicited increase of 3':5'-cyclic AMP by endogenous phosphodiesterase activator. [PDF]

Proceedings of the National Academy of Sciences, 1976
Experiments with cold exposure confirmed previous studies indicating that the endogenous protein acitvator of phosphodiesterase (PDEA) isolated by Cheung participates in the in vivo regulation of 3':5'-cyclic adenosine monophosphate (cAMP) in adrenal medulla.
M E, Gnegy, E, Costa, P, Uzunov
openaire   +4 more sources

Disinhibition of hippocampal CA3 neurons induced by suppression of an adenosine A1 receptor-mediated inhibitory tonus: Pre- and postsynaptic components [PDF]

, 1993
Intracellular recordings were performed on hippocampal CA3 neuronsin vitro to investigate the inhibitory tonus generated by endogenously produced adenosine in this brain region.
Alzheimer, Alzheimer, Alzheimer, Alzheimer, Andreasen, Arai, Ault, Ault, B. Sutor, Bauer, Beavo, Beavo, Ben-Ari, Bruns, Bruns, C. Alzheimer, Chamberlin, Daly, Dragunow, Dragunow, Dunwiddie, Dunwiddie, Dunwiddie, Fredholm, G. Ten Bruggencate, Gerber, Greene, Greene, Haas, Hablitz, Hablitz, Jackisch, Johnston, Linden, Linden, Llinás, Lohse, Madison, Malenka, Meghji, Miles, Moraidis, Nicholson, Pockett, Prestwich, Prince, Scholz, Schubert, Schubert, Smellie, Smellie, Smith, Snyder, Snyder, Sutor, Tanaka, Thompson, Thompson, Van Calker, Williams, Zetterström   +60 more
core   +1 more source