Results 161 to 170 of about 22,721 (206)
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Evidence for and some properties of a 3′, 5′- cyclic AMP phosphodiesterase inhibitor in potato
Biochemical and Biophysical Research Communications, 1972Summary Dialysis of potato 105,000 × g supernatant resulted in a dramatic increase in 3′, 5′- cyclic AMP phosphodiesterase activity, due to the removal of some unknown inhibitor of small molecular size, through this process. The inhibitor obtained by gel filtration was resistant to boiling at neutral, acidic, or alkaline pH and also to charcoal ...
Makoto Shimoyama +7 more
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Naunyn-Schmiedeberg's Archives of Pharmacology, 1972
Papaverine and eupaverin are potent inhibitors of 3′,5′-cyclic AMP phosphodiesterase from rabbit white skeletal muscle. These drugs inhibit more the activity associated with the particulate fractions than that associated with the soluble fraction.
G C, Toson, F, Carpenedo
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Papaverine and eupaverin are potent inhibitors of 3′,5′-cyclic AMP phosphodiesterase from rabbit white skeletal muscle. These drugs inhibit more the activity associated with the particulate fractions than that associated with the soluble fraction.
G C, Toson, F, Carpenedo
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Canadian Journal of Biochemistry, 1975
3′:5′-Cyclic-AMP phosphodiesterase (PDE) (EC 3.1.4.17) activity was measured in interscapular brown adipose tissue (BAT) and in white epididymal adipose tissue of rats acclimated to constant or fluctuating cold. Experiments were carried out on isolated adipocytes or tissue homogenates. In brown or white adipose tissue or isolated adipocyte homogenates,
R, Bertin, R, Portet
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3′:5′-Cyclic-AMP phosphodiesterase (PDE) (EC 3.1.4.17) activity was measured in interscapular brown adipose tissue (BAT) and in white epididymal adipose tissue of rats acclimated to constant or fluctuating cold. Experiments were carried out on isolated adipocytes or tissue homogenates. In brown or white adipose tissue or isolated adipocyte homogenates,
R, Bertin, R, Portet
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Journal of Medicinal Chemistry, 1982
Some penta-O-substituted analogues of quercetin were synthesized and tested for the inhibition of cytosolic and particulate rat brain cyclic AMP and cyclic GMP phosphodiesterase activities. Ten of these compounds are potent and highly selective inhibitors of cAMP hydrolysis with respect to cGMP hydrolysis.
M, Picq +4 more
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Some penta-O-substituted analogues of quercetin were synthesized and tested for the inhibition of cytosolic and particulate rat brain cyclic AMP and cyclic GMP phosphodiesterase activities. Ten of these compounds are potent and highly selective inhibitors of cAMP hydrolysis with respect to cGMP hydrolysis.
M, Picq +4 more
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Biochemical and Biophysical Research Communications, 1979
Summary A method is described to purify in a single step the inhibitor of the 3′–5′ cyclic AMP phosphodiesterase of D. discoideum by affinity chromatography to phosphodiesterase immobilized to Sepharose. Biologically active, pure inhibitor is eluted with 5M salt at high yields. Application of this technique to the study of mutants which overproduce
E, Dicou, P, Brachet
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Summary A method is described to purify in a single step the inhibitor of the 3′–5′ cyclic AMP phosphodiesterase of D. discoideum by affinity chromatography to phosphodiesterase immobilized to Sepharose. Biologically active, pure inhibitor is eluted with 5M salt at high yields. Application of this technique to the study of mutants which overproduce
E, Dicou, P, Brachet
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Molecular and Cellular Endocrinology, 1975
Partially purified, non-suppressible, insulin-like material (NSILA-S) was studied with respect to its effect on the levels of 3',5'-cyclic adenosine monophosphate (cAMP) and its mechanism of action in the control of this nucleotide in rat fat cells.
K D, Hepp +3 more
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Partially purified, non-suppressible, insulin-like material (NSILA-S) was studied with respect to its effect on the levels of 3',5'-cyclic adenosine monophosphate (cAMP) and its mechanism of action in the control of this nucleotide in rat fat cells.
K D, Hepp +3 more
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Biochemical and Biophysical Research Communications, 1972
Abstract We attempted to identify the low molecular sized 3′, 5′- cyclic AMP phosphodiesterase inhibitor in potato. Finding that the partially purified inhibitor yielded an elution pattern and a phosphodiesterase inhibition identical with those of inorganic phosphate in Sephadex G-25 column chromatography, and finding that the Rf value for this ...
M, Shimoyama +4 more
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Abstract We attempted to identify the low molecular sized 3′, 5′- cyclic AMP phosphodiesterase inhibitor in potato. Finding that the partially purified inhibitor yielded an elution pattern and a phosphodiesterase inhibition identical with those of inorganic phosphate in Sephadex G-25 column chromatography, and finding that the Rf value for this ...
M, Shimoyama +4 more
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Biochemical and Biophysical Research Communications, 1981
Summary A large scale purification of the inhibitor of the cAMP phosphodiesterase of Dictyostelium discoideum is achieved in one step by chromatography on Affi-Gel blue. The chromophoric component of the resin is responsible for the affinity. Caffeine and trifluoperazine partly inhibit the binding of the inhibitor while cAMP and AMP have no effect.
E, Dicou, P, Brachet
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Summary A large scale purification of the inhibitor of the cAMP phosphodiesterase of Dictyostelium discoideum is achieved in one step by chromatography on Affi-Gel blue. The chromophoric component of the resin is responsible for the affinity. Caffeine and trifluoperazine partly inhibit the binding of the inhibitor while cAMP and AMP have no effect.
E, Dicou, P, Brachet
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Plant Biosystems - An International Journal Dealing with all Aspects of Plant Biology, 2007
Abstract A 3′, 5′-cyclic-AMP phosphodiesterase (PDE) was detected and measured in the lichen Evernia prunastri. The percentage of hydrolysis of tritiated 3′, 5′-cyclic-adenosine monophosphate ([3H]-cAMP) and 3′, 5′-cyclic-guanosine monophosphate ([3H]-cGMP) by the PDE enzyme into tritiated 5′-adenosine-monophospahte ([3H]-AMP) and tritiated 5 ...
M. Segovia, F. L. Figueroa
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Abstract A 3′, 5′-cyclic-AMP phosphodiesterase (PDE) was detected and measured in the lichen Evernia prunastri. The percentage of hydrolysis of tritiated 3′, 5′-cyclic-adenosine monophosphate ([3H]-cAMP) and 3′, 5′-cyclic-guanosine monophosphate ([3H]-cGMP) by the PDE enzyme into tritiated 5′-adenosine-monophospahte ([3H]-AMP) and tritiated 5 ...
M. Segovia, F. L. Figueroa
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Chemischer Informationsdienst, 1974
AbstractDie Kondensation der 3‐Amino‐pyrazole (I) mit Acetylaceton (II) liefert die Kondensationsprodukte (III), die in der angegebenen Weise modifiziert werden.
T. NOVINSON +5 more
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AbstractDie Kondensation der 3‐Amino‐pyrazole (I) mit Acetylaceton (II) liefert die Kondensationsprodukte (III), die in der angegebenen Weise modifiziert werden.
T. NOVINSON +5 more
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