Results 61 to 70 of about 22,721 (206)

Blocking Lysine Crotonylation and Aerobic Glycolysis as Targeting Strategy Against mpox Virus Replication

Advanced Science, Volume 13, Issue 4, 19 January 2026.
Wei et al. report that MPXV infection induces aerobic glycolysis, a process mediated by the viral protein I3 through lysine crotonylation at its K102 residue. The acetyltransferase MYST1 catalyzes the crotonylation of I3 to inhibit the ubiquitin‐mediated degradation of WDR26.
Pengjun Wei, Zongzheng Zhao, Ruoqi Xu, Qin Yan, Liangzi Jiang, Fuxiao Geng, Yang Gu, Tianjiao Wang, Jing Zhou, Xiao Li, Qin Yan, Chun Lu, Wan Li   +12 more
wiley   +1 more source

NAD⁺ Reduction in Glutamatergic Neurons Induces Lipid Catabolism and Neuroinflammation in the Brain via SARM1

Advanced Science, Volume 13, Issue 6, 30 January 2026.
NAD⁺ homeostasis maintains neuronal integrity through opposing actions of NMNAT2 and SARM1. Loss of NMNAT2 in glutamatergic neurons reprograms cortical metabolism from glucose to lipid catabolism, depletes lipid stores, and triggers inflammation and neurodegeneration.
Zhen‐Xian Niou, Sen Yang, Andrea Enriquez, Nino A. Espinas, Anoosha Sri, Caliel D. Hines, Jason M. Tennessen, Chia‐Shan Wu, Jui‐Yen Huang, Hui‐Chen Lu   +9 more
wiley   +1 more source

Efecto del inhibidor de fosfodiesterasa tipo 4 -rolipram, sobre la maduración in vitro de oocitos bovinos Efeito do inibidor de fosfodiesterasa tipo 4 -rolipram, sobre a maturação in vitro de oocitos bovinos Effect of phosphodiesterase type 4-inhibitor rolipram on in vitro maturatrion of bovine oocytes

Revista Colombiana de Ciencias Pecuarias, 2008
Durante el proceso de maduración in vitro de oocitos, las gonadotropinas FSH y LH inducen la producción de AMPc. El AMPc tiene efecto dual, donde los altos niveles de AMPc intraoocitario mantienen su bloqueo meiótico, mientras que en las células de la ...
Yuddy S López, Ana M Mejía, Elder E Escobar, Bernardo Agudelo Jaramillo, Neil A Vásquez Araque, Hernán Echavarría   +5 more
doaj  

Amphiphilic Cu(II) Oxacyclen Complexes: From Oxidative Cleavage to Condensation of DNA

ChemBioChem, Volume 27, Issue 2, January 2026.
Monoalkylated Cu(II) oxacyclen complexes show a dual DNA effect: shorter alkyl chains enable ROS‐mediated DNA cleavage, whereas longer chains cause strong DNA condensation/aggregation. Thus, chain length controls activity. Using circular dichroism, UV/visible and fluorescence spectroscopy, atomic force microscopy, dynamic light scattering, and ...
Olga Verbitsky, Sebastián Hinojosa, Amr Mostafa, Deepak Ojha, Ilko Bald, Nora Kulak   +5 more
wiley   +1 more source

Digital image processing of optical density wave propagation in Dictyostelium discoideum and analysis of the effects of caffeine and ammonia [PDF]

, 1989
Waves of chemotactic movement during the early phase of aggregation in Dictyostelium discoideum were analyzed by digital image processing in a manner that immediately shows the following parameters: wave propagation velocity, period length, wave ...
Siegert, Florian, Weijer, Cornelis J.
core   +1 more source

Stimulator of interferon genes (STING)‐activating nanomedicines: Translating innate immune modulation into effective therapy for triple‐negative breast cancer

Clinical and Translational Medicine, Volume 16, Issue 1, January 2026.
Graphical representation of STING‐activated nanomedicines is for effective treatment of triple‐negative breast cancer. Abstract Triple‐negative breast cancer (TNBC), marked by profound immunosuppressive complexity, poses a critical challenge in therapy due to the absence of hormone receptors in its phenotype, making it unavailable for conventional ...
Harshita Singhai, Taha Alqahtani, Humood Al Shmrany, Garima Gupta, Umesh Kumar Patil, Amirhossein Sahebkar, Prashant Kesharwani   +6 more
wiley   +1 more source

[Regulation of the activity of 3', 5'-cyclic AMP phosphodiesterase by pancreatic hormones].

Problemy endokrinologii, 1979
The character of the insulin effect on the activity of phosphodiesterase (PDE) cAMP of various subcellular localization was studied in the liver of normal and diabetic rats. As a result of kinetic investigations for PDE cAMP preparations of the plasma membranes there were obtained kinetic characteristics of two PDE forms, differing by their affinity to
N V, Zin'ko, L K, Starosel'tseva
openaire   +1 more source

Serum Uric Acid as a Mediator of Insulin Resistance: Molecular Mechanisms and Metabolic Pathways

Endocrinology, Diabetes &Metabolism, Volume 9, Issue 1, January 2026.
Elevated SUA can lead to oxidative stress, endothelial dysfunction, inflammation and impaired function of adipocytes—all of which collectively impede insulin receptor activity and downstream signalling. Key pathways involved include activation of the NLRP3 inflammasome, suppression of AMPK and induction of mitochondrial dysfunction.
Nurshad Ali
wiley   +1 more source

Sildenafil helps the beat go on

Experimental Physiology, EarlyView.
Jules C. Hancox
wiley   +1 more source

Further Insights Into Anticholinergic Action Informed by Japanese Anticholinergic Risk Scale

Geriatrics &Gerontology International, Volume 26, Issue 1, January 2026.
ABSTRACT The increased anticholinergic burden caused by medications in older adults is one of the adverse drug reactions of particular concern, as it can exacerbate the onset of geriatric syndromes or induce cognitive dysfunction, and is also related to the issue of polypharmacy.
Masaki Mogi, Shuang Liu, Yasuyuki Suzuki, Yuuka Shibata, Shizuo Yamada   +4 more
wiley   +1 more source