EMD273316 & EMD95833, type 4 phosphodiesterase inhibitors, stimulate fibroblastic-colony formation by bone marrow cells via direct inhibition of PDE4 and the induction of endogenous prostaglandin synthesis [PDF]
, 2004 BACKGROUND: Type 4 phosphodiesterase (PDE4) inhibitors have been shown to stimulate bone formation in vivo and to stimulate osteoblastic differentiation in vitro.
Beier, Norbert +2 more
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Molecular, Enzymatic, and Cellular Characterization of Soluble Adenylyl Cyclase From Aquatic Animals. [PDF]
, 2018 The enzyme soluble adenylyl cyclase (sAC) is the most recently identified source of the messenger molecule cyclic adenosine monophosphate. sAC is evolutionarily conserved from cyanobacteria to human, is directly stimulated by [Formula: see text] ions ...
Acin-Perez +58 more
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Oocyte maturation and quality: role of cyclic nucleotides [PDF]
, 2016 Advance Publication first posted online on 15 July 2016 - Accepted manuscriptThe cyclic nucleotides, cAMP and cGMP, are the key molecules controlling mammalian oocyte meiosis.
De Vos, M. +9 more
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Cell Proliferation, 1977 ABSTRACTResting mammalian fibroblasts, either sparse and maintained in a serum‐free medium, or confluent and contact inhibited, are stimulated to divide by treatment with a preparation of 3′: 5′‐cyclic AMP phosphodiesterase. This enzyme preparation contained a low level of trypsin‐like and α‐chymotrypsin‐like activity, but its effect on cell growth ...
D A, Laurence, P, Dézelée, P, Jullien
openaire +2 more sources
Interaction between integrin α5 and PDE4D regulates endothelial inflammatory signalling [PDF]
, 2016 Atherosclerosis is primarily a disease of lipid metabolism and inflammation; however, it is also closely associated with endothelial extracellular matrix (ECM) remodelling, with fibronectin accumulating in the laminin–collagen basement membrane.
Anderson, Daniel Griffith +8 more
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Dopamine D1, D2 and mu-opioid receptors are co-expressed with adenylyl cyclase 5 and phosphodiesterase 7B mRNAs in striatal rat cells [PDF]
, 2013 El pdf es la versión post-print.Intracellular cAMP levels are regulated by cAMP synthesis and degradation rate. Nine isoforms of cAMP-synthesizing enzymes called adenylyl-cyclases (ACs) and eleven phosphodiesterases (PDEs) that degrade cyclic nucleotides
Griesshammer, Martin +2 more
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THE CONCISE GUIDE TO PHARMACOLOGY 2017/18:Enzymes [PDF]
, 2017 The Concise Guide to PHARMACOLOGY 2017/18 provides concise overviews of the key properties of nearly 1800 human drug targets with an emphasis on selective pharmacology (where available), plus links to an open access knowledgebase of drug targets and ...
, +11 more
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, 2018 3′-5′-cyclic adenosine monophosphate (cAMP) is a signaling messenger produced in response to the stimulation of cellular receptors, and has a myriad of functional applications depending on the cell type.
Bhogal, NK, Gorelik, J, Hasan, A
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A predictive computational model reveals that GIV/girdin serves as a tunable valve for EGFR-stimulated cyclic AMP signals. [PDF]
, 2019 Cellular levels of the versatile second messenger cyclic (c)AMP are regulated by the antagonistic actions of the canonical G protein → adenylyl cyclase pathway that is initiated by G-protein-coupled receptors (GPCRs) and attenuated by phosphodiesterases (
Getz, Michael +4 more
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Characterization of cyclic nucleotide phosphodiesterase isoenzymes in the human ureter and their functional role in vitro [PDF]
, 1994 Forssmann, W. G. +6 more
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