Results 61 to 70 of about 5,904 (191)

Intermolecular 1,3-dipolar cycloadditions of azomethine imines [PDF]

, 2007
Dipolar cycloadditions of azomethine imines, formed in situ from aldehydes and N1-alkyl-N2- acylhydrazines, with electron-deficient dipolarophiles produce pyrazolidines: mono-substituted dipolarophiles afford principally 4-substituted ...
Ray Jones (1249197), Stephen J. Hollis (7162967), James N. Iley (2383180)   +2 more
core  

Creating a Masterpiece. The Road to (and Beyond) Woodward and Hoffmann's 1969 Angewandte Chemie Treatise

The Chemical Record, EarlyView.
This publication describes how R. B. Woodward and Roald Hoffmann crafted their masterpiece publications. Illustrations include Woodward's first draft of the famous “Violations There are none. Nor can violations be expected of so fundamental a principle of maximum bonding.” Original but discarded text shows the stepwise paths toward the W‐H masterpieces.
Jeffrey I. Seeman
wiley   +1 more source

Late‐Stage Functionalization of Peptides on the Solid Phase

Angewandte Chemie International Edition, Volume 65, Issue 31, 27 July 2026.
Peptide modifications are essential to control pharmacodynamic and pharmacokinetic properties of peptide drugs. Consequently, strategies that allow for efficient and rapid incorporation of non‐canonical modifications into peptides in parallel formats are highly sought after.
Marius Werner, Truc Lam Pham, Franziska Thomas   +2 more
wiley   +1 more source

Pd(II)‐Catalyzed Strategies for the β‐Arylation of α‐Amino Acids: An Overview

Chemistry – A European Journal, Volume 32, Issue 28, 25 July 2026.
The graphical abstract summarizes the review “Pd(II)‐Catalyzed Strategies for the β‐Arylation of α‐Amino Acids: An Overview”, highlighting representative Pd(II)‐catalyzed methods for the β‐arylation of α‐amino acids. Key mechanistic features, substrate diversity, and synthetic relevance of these transformations are showcased. Abstract Metal‐catalyzed C─
Davide Illuminati, Claudio Trapella, Vinicio Zanirato, Virginia Cristofori, Anna Fantinati   +4 more
wiley   +1 more source

Total Syntheses of Agelamadin F and (±)‐Tauroacidin A, Enabled by NaClO2‐Mediated Coupling Reactions of Oroidin and Amines

Chemistry – A European Journal, Volume 32, Issue 27, 17 July 2026.
Total syntheses of agelamadin F and (±)‐tauroacidin A were achieved by sodium chlorite (NaClO2)‐mediated oxidative C─N coupling. Nine C15–N–amino acid‐substituted oroidin derivatives were successfully prepared to demonstrate the applicability and versatility of this oxidative coupling reaction.
Ryosuke Hirozumi, Yuta Kudo, Yuko Cho, Mari Yotsu‐Yamashita   +3 more
wiley   +1 more source

Organocatalytic and stereoselective [3+2] cycloadditions of azomethine imines with alpha,beta-unsaturated aldehydes [PDF]

, 2006
Bipyrazolidin-3-one derivatives are biologically significant compounds and their importance has increased in the past decades. In this paper, the first stereoselective [3 + 2] dipolar cycloadditions of azomethine imines with alpha,beta-unsaturated ...
Du, W, Yuan, XH, Wu, Y, Ding, LS, Chen, YC, Sichuan Univ, W China Sch Pharm, Key LDrug Targeting Educ Minist, Chengdu 610041, Peoples R China., Chen, W, Li, R, Chen, YC   +7 more
core  

Nuclear Quantum Effects on the Organic Bifurcation Reaction in Microsolvated Water Clusters: Ring‐Polymer Molecular Dynamics Calculations Using an Explicit Solvation Model

Journal of Computational Chemistry, Volume 47, Issue 19, 15 July 2026.
Ring‐polymer molecular dynamics in explicit water clusters shows that nuclear quantum effects steer an organic bifurcation reaction—enhancing the minor (4 + 2) channel and accelerating water‐mediated proton transfer—proving that accurate aqueous reaction dynamics require both explicit solvation and nuclear quantum effects. ABSTRACT Solvent environments
Shoto Nakagawa, Hayato Matsubuchi, Haruki Ota, Toshiyuki Takayanagi, Tatsuhiro Murakami   +4 more
wiley   +1 more source

Fused 1,5-benzothiazepines from o-aminothiophenol and its derivatives as versatile synthons

Acta Chimica Slovenica, 2014
This review describes the reactions of o-aminothiophenol and its derivatives as building blocks for the synthesis of polyfunctionalised 1,5-benzothiazipines with pharmacological interest.
Batchu Chandra Sekhar
doaj  

Reaction Enumeration Based on NBO‐Informed Molecular Graphs

Journal of Computational Chemistry, Volume 47, Issue 19, 15 July 2026.
NBO‐informed molecular graphs represent chemistry via valence orbitals rather than atomic connectivity, enabling consistent reaction analysis across environments. By identifying delocalized motifs and increasing complexity adaptively, the framework enables efficient exploration of inaccessible mechanisms and diverse catalytic and reaction networks for ...
Javier E. Alfonso‐Ramos, Thijs Stuyver
wiley   +1 more source

Oligonucleotides Post‐Synthetic Modifications: An Overview of Clickable Nucleoside Phosphoramidites Suitable for Solid‐Phase Synthesis

ChemBioChem, Volume 27, Issue 13, 14 July 2026.
Clickable nucleoside phosphoramidites can be incorporated into oligonucleotides via solid‐phase synthesis (SPOS), enabling rapid and site‐specific post‐functionalization using bioorthogonal reactions. This review highlights their design, synthetic accessibility, and SPOS incorporation requirements, along with the kinetics and efficiency of post ...
Sébastien Depienne, Alexandra Bristiel, Dominique Urban, Dominique Guianvarc’h   +3 more
wiley   +1 more source