Results 21 to 30 of about 19,351,043 (289)

CREB is a key regulator of striatal vulnerability in chemical and genetic models of Huntington's disease

Neurobiology of Disease, 2009
Evidence of dysregulation of the CREB/CRE transcriptional pathway in animal models of Huntington's disease (HD) suggests that strategies designed to augment CRE-mediated transcription may be of therapeutic value. Here, we investigated the consequences of
Yun-Sik Choi, Boyoung Lee, Hee-Yeon Cho, Iza B. Reyes, Xin-An Pu, Takaomi C. Saido, Kari R. Hoyt, Karl Obrietan   +7 more
doaj   +1 more source

Alleviative effects of magnetic Fe3O4 nanoparticles on the physiological toxicity of 3-nitrophenol to rice (Oryza sativa L.) seedlings

Open Life Sciences, 2022
In the present study, we explored whether magnetic iron oxide nanoparticles (MNPs-Fe3O4) can be used to alleviate the toxicity of 3-nitrophenol (3-NP) to rice (Oryza sativa L.) seedlings grown under hydroponic conditions.
Sainao Wangqing, Shi Zhenzhen, Pang Hailong, Feng Hanqing   +3 more
doaj   +1 more source

Transparent conductive oxide films mixed with gallium oxide nanoparticle/single-walled carbon nanotube layer for deep ultraviolet light-emitting diodes [PDF]

, 2013
We propose a transparent conductive oxide electrode scheme of gallium oxide nanoparticle mixed with a single-walled carbon nanotube (Ga(2)O(3) NP/SWNT) layer for deep ultraviolet light-emitting diodes using spin and dipping methods.
Hee-Dong Kim, Ho-Myoung An, Kyoeng Kim, Tae Kim   +3 more
core   +1 more source

Aquaporin-3 Attenuates Oxidative Stress-Induced Nucleus Pulposus Cell Apoptosis Through Regulating the P38 MAPK Pathway

Cellular Physiology and Biochemistry, 2018
Background/Aims: Previous studies have shown that oxidative damage is a main contributor to disc nucleus pulposus (NP) cell apoptosis. Aquaporin-3 (AQP-3) facilitates reactive oxygen species (ROS) scavenging and thus alleviates oxidative injury in other ...
Yichun Xu, Hui Yao, Qiyou Wang, Wenbin Xu, Kaihua Liu, Junbin Zhang, Huiqing Zhao, Gang Hou   +7 more
doaj   +1 more source

HMGB1 Promotes Mitochondrial Dysfunction-Triggered Striatal Neurodegeneration via Autophagy and Apoptosis Activation. [PDF]

PLoS ONE, 2015
Impairments in mitochondrial energy metabolism are thought to be involved in many neurodegenerative diseases. The mitochondrial inhibitor 3-nitropropionic acid (3-NP) induces striatal pathology mimicking neurodegeneration in vivo. Previous studies showed
Lin Qi, Xue Sun, Feng-E Li, Bao-Song Zhu, Frank K Braun, Zhi-Qiang Liu, Jin-Le Tang, Chao Wu, Fei Xu, Hui-Han Wang, Luis A Velasquez, Kui Zhao, Feng-Rui Lei, Ji-Gang Zhang, Yun-Tian Shen, Jian-Xuan Zou, Hui-Min Meng, Gang-Li An, Lin Yang, Xing-Ding Zhang   +19 more
doaj   +1 more source

Postgerminative growth and lipid catabolism in oilseeds lacking the glyoxylate cycle [PDF]

, 2000
The glyoxylate cycle is regarded as essential for postgerminative growth and seedling establishment in oilseed plants. We have identified two allelic Arabidopsis mutants, icl-1 and icl-2, which lack the glyoxylate cycle because of the absence of the key ...
Bryce, J.H., Eastmond, P.J., Germain, V., Graham, I.A., Lange, P.R., Smith, S.M.   +5 more
core   +2 more sources

Erythropoietin and sonic hedgehog mediate the neuroprotective effects of brain-derived neurotrophic factor against mitochondrial inhibition

Neurobiology of Disease, 2010
Brain-derived neurotrophic factor (BDNF) deficiency and mitochondrial dysfunction have been implicated in the pathogenesis of Huntington's disease (HD).
Chia-Lin Wu, Shang-Der Chen, Jiu-Haw Yin, Chi-Shin Hwang, Ding-I Yang   +4 more
doaj   +1 more source

Microglial activation and cell death induced by the mitochondrial toxin 3-nitropropionic acid: in vitro and in vivo studies

Neurobiology of Disease, 2003
Metabolic impairment of neurons has been implicated in several neurological disorders, but it is not at present known whether such metabolic impairment has deleterious effects on microglia, the phagocytic cells of the central nervous system (CNS). In the
Jae K Ryu, Atsushi Nagai, Jean Kim, Min C Lee, James G McLarnon, Seung U Kim   +5 more
doaj   +1 more source

Magnetic Monopoles, Gauge Invariant Dynamical Variables and Georgi Glashow Model [PDF]

, 1997
We investigate Georgi-Glashow model in terms of a set of explicitly SO(3) gauge invariant dynamical variables. In the new description a novel compact abelian gauge invariance emerges naturally.
't Hooft, 't Hooft, 't Hooft, Adriano Di Giacomo, Akhmedov, Bardakci, D' Adda, Dirac, Dirac, Giacomo, Kronfeld, Mandelstam, Manu Mathur, Mathur, Polyakov, Polyakov, Polyakov, Polyakov, Weinberg, Witten, Yang   +20 more
core   +2 more sources

A Comparative Assessment of Nanotoxicity Induced by Metal (Silver, Nickel) and Metal Oxide (Cobalt, Chromium) Nanoparticles in Labeo rohita

Nanomaterials, 2019
In the present in vivo study, we provide a comparison of toxicological consequences induced by four different types of spherical nanoparticles (NPs)—silver nanoparticles (AgNPs, 40 ± 6 nm), nickel (NiNPs, 43 ± 6 nm), cobalt oxide ...
Zakia Kanwal, Muhammad Akram Raza, Farkhanda Manzoor, Saira Riaz, Ghazala Jabeen, Shafaq Fatima, Shahzad Naseem   +6 more
doaj   +1 more source