Results 31 to 40 of about 13,770,514 (290)

PGMD/curcumin nanoparticles for the treatment of breast cancer

Scientific Reports, 2021
The present study aims at developing PGMD (poly-glycerol-malic acid-dodecanedioic acid)/curcumin nanoparticles based formulation for anticancer activity against breast cancer cells. The nanoparticles were prepared using both the variants of PGMD polymer (
Mankamna Kumari, Nikita Sharma, Romila Manchanda, Nidhi Gupta, Asad Syed, Ali H. Bahkali, Surendra Nimesh   +6 more
doaj   +1 more source

The Use of the Mitochondrial Toxin 3-NP to Uncover Cellular Dysfunction in Huntington’s Disease [PDF]

, 2012
Degenerative diseases that affect the nervous system are characterized by a progressive alteration of specific neuronal populations and normally end in cell death. Some neurodegenerative disorders exhibit a clear genetic origin, such as in the case of Huntington’s Disease (HD); however, most neurodegenerative diseases do not have a genetic cause ...
Elizabeth Hernndez-Echeagaray, Gabriela De la Rosa-Lpez, Ernesto Mendoza-Duarte   +2 more
openaire   +1 more source

Overexpression of Aquaporin-3 Alleviates Hyperosmolarity-Induced Nucleus Pulposus Cell Apoptosis via Regulating the ERK1/2 Pathway

Pain Research and Management, 2022
Intervertebral disc degeneration (IDD) is closely related to osmolarity, which fluctuates with daily activities, and hyperosmolarity may be a contributor to nucleus pulposus (NP) cells apoptosis.
Zetong Zhang, Chen Zhao, Ruijie Zhang, Yiyang Wang, Yanzhu Hu, Qiang Zhou, Pei Li   +6 more
doaj   +1 more source

Effect of Air Annealing on the Structural, Textural, Magnetic, Thermal and Luminescence Properties of Cerium Fluoride Nanoparticles

Physchem, 2022
This paper presents the physicochemical characteristics of CeF3 nanopowder (NP) obtained via electron evaporation. The initial NP was annealed in air (200–500 °C) for 30 min.
Vladislav Ilves, Aidar Murzakaev, Sergey Sokovnin, Tat’yana Sultanova, Olga Svetlova, Mikhail A. Uimin, Maria Ulitko, Mikhail Zuev   +7 more
doaj   +1 more source

P vs NP: P is Equal to NP: Desired Proof

, 2021
Computations and computational complexity are fundamental for mathematics and all computer science, including web load time, cryptography (cryptocurrency mining), cybersecurity, artificial intelligence, game theory, multimedia processing, computational ...
Zulfia A. Chotchaeva
core   +1 more source

FK506 prevents mitochondrial-dependent apoptotic cell death induced by 3-nitropropionic acid in rat primary cortical cultures

Neurobiology of Disease, 2004
The mitochondrial toxin 3-nitropropionic acid (3-NP) has been largely used to study neurodegenerative disorders in which bioenergetic defects are implicated.
Sandra Almeida, António Domingues, Luís Rodrigues, Catarina R. Oliveira, A. Cristina Rego   +4 more
doaj   +1 more source

Clinical Outcome of Invasive Pituitary Prolactinomas Treated with Cabergoline

مجله كليه طب الكندي, 2020
Background: Treatment of invasive prolactinoma, which has several characteristics including invasive growth into cavernous sinuses and formation of giant adenomas compressing adjacent neural structures, resulting in neurological dysfunction, has been ...
Bassam M Flamerz Arkawazi
doaj   +1 more source

Reduced mitochondrial complex II activity enhances cell death via intracellular reactive oxygen species in STHdhQ111 striatal neurons with mutant huntingtin

Journal of Pharmacological Sciences, 2021
Huntington's disease (HD) is an inherited neurodegenerative disorder caused by CAG repeat expansion in the huntingtin (HTT) gene. Here, we examined the effects of antioxidants on 3-nitropropionic acid (3-NP; a mitochondrial complex II inhibitor)-induced ...
Noria Okada, Tomohiro Yako, Shinsuke Nakamura, Masamitsu Shimazawa, Hideaki Hara   +4 more
doaj   +1 more source

Effect of cilostazol (100 mg/kg, p.o) on striatal histopathological photomicrographs in 3-NP-treated rats.

, 2018
Sections A and B show normal neuronal structure of rats receiving saline and cilostazol, respectively. Section of (C) 3-NP treated group show a significant neuronal damage with severe neuronal necrosis and neuronophagia, (D) focal gliosis, and (E ...
Dalia M. El-Tanbouly (5797460), Hanan El-Abhar (5797451), Walaa Wadie (5797457), Mai A. Abd El Fattah (5797454)   +3 more
core   +1 more source

Identification of cyclin D1 as a major modulator of 3-nitropropionic acid-induced striatal neurodegeneration

Neurobiology of Disease, 2022
Mitochondria dysfunction occurs in the aging brain as well as in several neurodegenerative disorders and predisposes neuronal cells to enhanced sensitivity to neurotoxins.
Paula Dietrich, Shanta Alli, Megan K. Mulligan, Rachel Cox, David G. Ashbrook, Robert W. Williams, Ioannis Dragatsis   +6 more
doaj   +1 more source