Results 1 to 10 of about 178,790 (312)

Rotating and Neurochemical Activity of Rats Lesioned with Quinolinic Acid and Transplanted with Bone Marrow Mononuclear Cells

Behavioral Sciences, 2018
Huntington’s disease (HD) is an inherited, neurodegenerative disorder that results from the degeneration of striatal neurons, mainly GABAergic neurons. The study of neurochemical activity has provided reliable markers to explain motor disorders. To
Teresa Serrano Sánchez, María Elena González Fraguela, Lisette Blanco Lezcano, Esteban Alberti Amador, Beatriz Caballero Fernández, María de los Ángeles Robinson Agramonte, Lourdes Lorigados Pedre, Jorge A Bergado Rosado   +7 more
doaj   +1 more source

Basal Ganglia Neuromodulation Over Multiple Temporal and Structural Scales—Simulations of Direct Pathway MSNs Investigate the Fast Onset of Dopaminergic Effects and Predict the Role of Kv4.2

Frontiers in Neural Circuits, 2018
The basal ganglia are involved in the motivational and habitual control of motor and cognitive behaviors. Striatum, the largest basal ganglia input stage, integrates cortical and thalamic inputs in functionally segregated cortico-basal ganglia-thalamic ...
Robert Lindroos, Matthijs C. Dorst, Kai Du, Marko Filipović, Daniel Keller, Maya Ketzef, Alexander K. Kozlov, Arvind Kumar, Arvind Kumar, Mikael Lindahl, Anu G. Nair, Juan Pérez-Fernández, Sten Grillner, Gilad Silberberg, Jeanette Hellgren Kotaleski, Jeanette Hellgren Kotaleski   +15 more
doaj   +1 more source

Brain Processing of Contagious Itch in Patients with Atopic Dermatitis

Frontiers in Psychology, 2017
Several studies show that itch and scratching cannot only be induced by pruritogens like histamine or cowhage, but also by the presentation of certain (audio-) visual stimuli like pictures on crawling insects or videos showing other people scratching ...
Christina Schut, Hideki Mochizuki, Hideki Mochizuki, Shoshana K. Grossman, Andrew C. Lin, Christopher J. Conklin, Feroze B. Mohamed, Uwe Gieler, Joerg Kupfer, Gil Yosipovitch   +9 more
doaj   +1 more source

Pauses in cholinergic interneuron firing exert an inhibitory control on striatal output in vivo

eLife, 2018
The cholinergic interneurons (CINs) of the striatum are crucial for normal motor and behavioral functions of the basal ganglia. Striatal CINs exhibit tonic firing punctuated by distinct pauses.
Stefano Zucca, Aya Zucca, Takashi Nakano, Sho Aoki, Jeffery Wickens   +4 more
doaj   +1 more source

Dopamine neurons projecting to the posterior striatum form an anatomically distinct subclass

eLife, 2015
Combining rabies-virus tracing, optical clearing (CLARITY), and whole-brain light-sheet imaging, we mapped the monosynaptic inputs to midbrain dopamine neurons projecting to different targets (different parts of the striatum, cortex, amygdala, etc) in ...
William Menegas, Joseph F Bergan, Sachie K Ogawa, Yoh Isogai, Kannan Umadevi Venkataraju, Pavel Osten, Naoshige Uchida, Mitsuko Watabe-Uchida   +7 more
doaj   +1 more source

Striatal Dopaminergic Deficit and Sleep in Idiopathic Rapid Eye Movement Behaviour Disorder: An Explorative Study

Nature and Science of Sleep, 2021
Danielle Wasserman,1,2,* Dorothea Bindman,1,* Alexander D Nesbitt,1– 3 Diana Cash,4 Milan Milosevic,5 Paul T Francis,6 K Ray Chaudhuri,7 Guy D Leschziner,1,2 Luigi Ferini-Strambi,8 Clive Ballard,9 Amy Eccles,10 Ivana Rosenzweig1,2 1Sleep and Brain ...
Wasserman D, Bindman D, Nesbitt AD, Cash D, Milosevic M, Francis PT, Chaudhuri KR, Leschziner GD, Ferini-Strambi L, Ballard C, Eccles A, Rosenzweig I   +11 more
doaj  

Striatal dual cholinergic /GABAergic transmission in Parkinson disease: friends or foes?

Cell Stress, 2018
The rule of one terminal and one transmitter acting on one synapse clearly fails to cover the complexity of chemical synapse operation in the brain. Compelling evidence now indicates that two transmitters can be released from the same terminal, acting in
Natalia Lozovaya, Yehezkel Ben-Ari, Constance Hammond   +2 more
doaj   +1 more source

Common and Distinct Functional Brain Networks for Intuitive and Deliberate Decision Making

Brain Sciences, 2019
Reinforcement learning studies in rodents and primates demonstrate that goal-directed and habitual choice behaviors are mediated through different fronto-striatal systems, but the evidence is less clear in humans.
Burak Erdeniz, John Done
doaj   +1 more source

Modification of Monoaminergic Activity by MAO Inhibitors Influences Methamphetamine Actions

Drug Target Insights, 2006
Methamphetamine (METH) abuse is a serious health and social problem worldwide. At present, however, there are no effective medications for the treatment of METH abuse.
Junichi Kitanaka, Nobue Kitanaka, Motohiko Takemura   +2 more
doaj  

DNA methylation profiling in Huntington's disease reveals disease associated changes in the striatum. [PDF]

Clin Epigenetics
Wheildon G, Smith AR, Weymouth L, Harvey J, Kouhsar M, MacBean LF, Troakes C, Pishva E, Smith RG, Lunnon K.   +9 more
europepmc   +1 more source