Results 21 to 30 of about 264,556 (306)
NT-4/5 Exacerbates Free Radical-Induced Neuronal Necrosis in Vitro and in Vivo
Neurobiology of Disease, 2000 Neurotrophins render neurons highly vulnerable to certain injuries. We examined the possibility that NT-4/5 would enhance free radical neurotoxicity in vivo as well as in vitro.
Seok J. Won +6 more
doaj +1 more source
Adult Neurogenesis and Stroke: A Tale of Two Neurogenic Niches
Frontiers in Neuroscience, 2021 In the aftermath of an acute stroke, numerous signaling cascades that reshape the brain both in the perilesional zone as well as in more distal regions are activated.
Mihai Ceanga +4 more
doaj +1 more source
Frontostriatal Maturation Predicts Cognitive Control Failure to Appetitive Cues in Adolescents [PDF]
, 2011 Adolescent risk-taking is a public health issue that increases the odds of poor lifetime outcomes. One factor thought to influence adolescents' propensity for risk-taking is an enhanced sensitivity to appetitive cues, relative to an immature capacity to ...
B. J. Casey +7 more
core +2 more sources
Анналы клинической и экспериментальной неврологии, 2017 Introduction.Huntingtons disease (HD) is a severe neurodegenerativedisorder characterized by choreic hyperkinesis, cognitivedecline, behavioral disorders, and progressive neuronal death,mostly in the striatum.
Alla V. Stavrovskaya +4 more
doaj +1 more source
Kinetics and durability of transgene expression after intrastriatal injection of AAV9 vectors
Frontiers in Neurology, 2022 Understanding the kinetics and durability of AAV-mediated transgene expression in the brain is essential for conducting basic neuroscience studies as well as for developing gene therapy approaches for CNS diseases.
Bradley S. Hollidge +9 more
doaj +1 more source
Dopamine-D1 and δ-opioid receptors co-exist in rat striatal neurons [PDF]
, 2006 Cocaine’s enhancement of dopaminergic neurotransmission in the mesolimbic pathway plays a critical role in the initial reinforcing properties of this drug. However, other neurotransmitter systems are also integral to the addiction process.
Ambrose-Lanci, L. M. +3 more
core +2 more sources
Experience of experimental simulation of Huntington’s disease
Анналы клинической и экспериментальной неврологии, 2017 Huntingtons disease (HD) is an autosomal dominant neurodegenerativedisease characterized by choreic hyperkinesia, cognitivedecline, behavioral disorders, and progressive neuronaldeath affecting primarily the striatum.
A. V. Stavrovskaya +5 more
doaj +1 more source
A Mechanism Linking Two Known Vulnerability Factors for Alcohol Abuse: Heightened Alcohol Stimulation and Low Striatal Dopamine D2 Receptors [PDF]
, 2019 Alcohol produces both stimulant and sedative effects in humans and rodents. In humans, alcohol abuse disorder is associated with a higher stimulant and lower sedative responses to alcohol.
Bocarsly, Miriam E. +8 more
core +1 more source
Ventral Caudate and Anterior Insula Recruitment During Value Estimation of Passionate Rewarding Cues
Frontiers in Neuroscience, 2020 “Wanting”, a component of reward processing, is a motivational property that guides decision making in goal-oriented behavior. This includes behavior aiming at supporting relational bonds, even at the group level.
Isabel Catarina Duarte +6 more
doaj +1 more source
Frontiers in Neuroscience, 2020 Patients with chronic schizophrenia often display enlarged striatal volumes, and antipsychotic drugs may contribute via the dopamine D2/3 receptor (D2/3R) blockade.
Helle G. Andersen +19 more
doaj +1 more source