Results 21 to 30 of about 147,438 (217)

Effects of an Adenosine A2A Receptor Antagonist on Striatal Dopamine D2-Type Receptor Availability: A Randomized Control Study Using Positron Emission Tomography

Frontiers in Neuroscience, 2021
Introduction: Altered dopaminergic neurotransmission, especially in the functioning of dopamine D2-type receptors, is considered central to the etiology of a variety of neuropsychiatric disorders.
Kyoji Okita, Kyoji Okita, Kyoji Okita, Koichi Kato, Yoko Shigemoto, Noriko Sato, Toshihiko Matsumoto, Toshihiko Matsumoto, Hiroshi Matsuda, Hiroshi Matsuda, Hiroshi Matsuda   +10 more
doaj   +1 more source

Comparison and Functional Genetic Analysis of Striatal Protein Expression Among Diverse Inbred Mouse Strains

Frontiers in Molecular Neuroscience, 2019
C57BL/6J (B6) and DBA/2J (D2) inbred mouse strains are highly variable genetically and differ in a large number of behavioral traits related to striatal function, including depression, anxiety, stress response, and response to drugs of abuse. The genetic
Cory Parks, Francesco Giorgianni, Byron C. Jones, Sarka Beranova-Giorgianni, Bob M. Moore II, Megan K. Mulligan   +5 more
doaj   +1 more source

A Biologically Plausible Architecture of the Striatum to Solve Context-Dependent Reinforcement Learning Tasks

Frontiers in Neural Circuits, 2017
Basal ganglia circuit is an important subcortical system of the brain thought to be responsible for reward-based learning. Striatum, the largest nucleus of the basal ganglia, serves as an input port that maps cortical information. Microanatomical studies
Sabyasachi Shivkumar, Vignesh Muralidharan, V. Srinivasa Chakravarthy   +2 more
doaj   +1 more source

Comparison of bloodstream infections due to Corynebacterium striatum, MRSA, and MRSE

BMC Infectious Diseases
Background Corynebacterium striatum (C. striatum), a common skin and mucosal colonizer, is increasingly considered as an opportunistic pathogen causing bloodstream infections (BSIs). This study aims to investigate the clinical features and outcomes of C.
Shu-Hua He, Yan Chen, Hong-Li Sun, Shan Li, Shi-Tong Diao, Yi-Fan Wang, Zhuo-Xin He, Li Weng, Jin-Min Peng, Bin Du   +9 more
doaj   +1 more source

Prodromal Lewy Body Disorder Features in REM Sleep Behavior Disorder With Biomarker‐Defined Synucleinopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Isolated rapid eye movement sleep behavior disorder (iRBD) is a prodromal state for Lewy body disorders and exhibits biological heterogeneity that may influence clinical expression and progression. We examined clinical features in individuals with iRBD and biomarker‐defined synucleinopathy.
Daniel Weintraub, Michele K. York, Roseanne Dobkin, Anuprita R. Nair, Ryan Kurth, David‐Erick Lafontant, Chelsea Caspell‐Garcia, Roy N. Alcalay, Ethan G. Brown, Lana M. Chahine, Christopher Coffey, Tatiana Foroud, Douglas Galasko, Karl Kieburtz, Kenneth Marek, Kalpana Merchant, Brit Mollenhauer, Kathleen L. Poston, Andrew Siderowf, Cristina Simonet, Tanya Simuni, Caroline M. Tanner, Thomas F. Tropea, Aleksandar Videnovic, The Parkinson's Progression Markers Initiative   +24 more
wiley   +1 more source

Uptake of 18F-AV45 in the Putamen Provides Additional Insights into Alzheimer’s Disease beyond the Cortex

Biomolecules
Cortical uptake in brain amyloid positron emission tomography (PET) is increasingly used for the biological diagnosis of Alzheimer’s disease (AD); however, the clinical and biological relevance of the striatum beyond the cortex in amyloid PET scans ...
Zhengshi Yang, Jefferson W. Kinney, Dietmar Cordes, The Alzheimer’s Disease Neuroimaging Initiative   +3 more
doaj   +1 more source

Noise exposure in early adulthood causes age-dependent and brain region-specific impairments in cognitive function

Frontiers in Neuroscience, 2022
Hearing loss is a chronic health condition that affects millions of people worldwide. In addition to age-related hearing impairment, excessive noise exposure is a leading cause of hearing loss. Beyond the devastating effects of hearing impairment itself,
Salonee V. Patel, Courtney M. DeCarlo, Shae A. Book, Ashley L. Schormans, Shawn N. Whitehead, Brian L. Allman, Sarah H. Hayes   +6 more
doaj   +1 more source

Neurochemical Endpoints to Inform Early‐Stage Trials of Spinocerebellar Ataxia 2 and 3 in a Multisite Setting

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Neurochemical levels measured by brain MR spectroscopy (MRS) have been proposed as endpoints for clinical trials in early‐stage spinocerebellar ataxia (SCA) trials. We tested their trial‐readiness by quantifying neurochemicals in three affected brain regions in early‐stage cohorts of SCA2 and SCA3, examining their reproducibility in ...
James M. Joers, Yaqiao Wei, Dinesh K. Deelchand, Adam Berrington, Young Woo Park, Guita Banan, Michal Povazan, Jens T. Rosenberg, André J. W. van der Kouwe, Tetsuo Ashizawa, Khalaf O. Bushara, Chiadi U. Onyike, Sub H. Subramony, Jeremy D. Schmahmann, Brian J. Soher, Peter B. Barker, Thomas H. Mareci, Eva‐Maria Ratai, Lynn E. Eberly, Gülin Öz   +19 more
wiley   +1 more source

Dopamine D1 and Glutamate Receptors Co-operate With Brain-Derived Neurotrophic Factor (BDNF) and TrkB to Modulate ERK Signaling in Adult Striatal Slices

Frontiers in Cellular Neuroscience, 2020
In the striatum, the input nucleus of the basal ganglia, the extracellular-signal-regulated kinase (ERK) pathway, necessary for various forms of behavioral plasticity, is triggered by the combined engagement of dopamine D1 and ionotropic glutamate ...
Ilaria Morella, Ilaria Morella, Harriet Hallum, Harriet Hallum, Riccardo Brambilla, Riccardo Brambilla   +5 more
doaj   +1 more source

Genetic tagging of the adenosine A2A receptor reveals its heterogeneous expression in brain regions

Frontiers in Neuroanatomy, 2022
The adenosine A2A receptor (A2AR), a G protein-coupled receptor, is involved in numerous and varied physiological and pathological processes, including inflammation, immune responses, blood flow, and neurotransmission.
Muran Wang, Zewen Li, Yue Song, Qiuqin Sun, Lu Deng, Lu Deng, Zhiqing Lin, Yang Zeng, Chunhong Qiu, Jingjing Lin, Jingjing Lin, Hui Guo, Jiangfan Chen, Wei Guo   +13 more
doaj   +1 more source