Results 41 to 50 of about 264,556 (306)

Effects of an Adenosine A2A Receptor Antagonist on Striatal Dopamine D2-Type Receptor Availability: A Randomized Control Study Using Positron Emission Tomography

Frontiers in Neuroscience, 2021
Introduction: Altered dopaminergic neurotransmission, especially in the functioning of dopamine D2-type receptors, is considered central to the etiology of a variety of neuropsychiatric disorders.
Kyoji Okita, Kyoji Okita, Kyoji Okita, Koichi Kato, Yoko Shigemoto, Noriko Sato, Toshihiko Matsumoto, Toshihiko Matsumoto, Hiroshi Matsuda, Hiroshi Matsuda, Hiroshi Matsuda   +10 more
doaj   +1 more source

Striatal cholinergic interneurons generate beta and gamma oscillations in the corticostriatal circuit and produce motor deficits [PDF]

, 2016
Cortico-basal ganglia-thalamic (CBT) neural circuits are critical modulators of cognitive and motor function. When compromised, these circuits contribute to neurological and psychiatric disorders, such as Parkinson's disease (PD).
Bucklin, Mark, Han, Xue, Kondabolu, Krishnakanth, Kopell, Nancy, McCarthy, Michelle M., Roberts, Erik A.   +5 more
core   +1 more source

Comparison of bloodstream infections due to Corynebacterium striatum, MRSA, and MRSE

BMC Infectious Diseases
Background Corynebacterium striatum (C. striatum), a common skin and mucosal colonizer, is increasingly considered as an opportunistic pathogen causing bloodstream infections (BSIs). This study aims to investigate the clinical features and outcomes of C.
Shu-Hua He, Yan Chen, Hong-Li Sun, Shan Li, Shi-Tong Diao, Yi-Fan Wang, Zhuo-Xin He, Li Weng, Jin-Min Peng, Bin Du   +9 more
doaj   +1 more source

Rising prevalence and drug resistance of Corynebacterium striatum in lower respiratory tract infections

Frontiers in Cellular and Infection Microbiology
Corynebacterium striatum (C. striatum) is a Gram-positive bacterium commonly colonizing the skin and mucosa in healthy individuals and hospitalized patients. Traditionally regarded as a contaminant, C.
Wei Li, Mingyue Gao, Jinyan Yu
doaj   +1 more source

Comparison and Functional Genetic Analysis of Striatal Protein Expression Among Diverse Inbred Mouse Strains

Frontiers in Molecular Neuroscience, 2019
C57BL/6J (B6) and DBA/2J (D2) inbred mouse strains are highly variable genetically and differ in a large number of behavioral traits related to striatal function, including depression, anxiety, stress response, and response to drugs of abuse. The genetic
Cory Parks, Francesco Giorgianni, Byron C. Jones, Sarka Beranova-Giorgianni, Bob M. Moore II, Megan K. Mulligan   +5 more
doaj   +1 more source

Time-Restricted Feeding Improves Circadian Dysfunction as well as Motor Symptoms in the Q175 Mouse Model of Huntington's Disease. [PDF]

, 2018
Huntington's disease (HD) patients suffer from a progressive neurodegeneration that results in cognitive, psychiatric, cardiovascular, and motor dysfunction.
Colwell, Christopher S, Cutler, Tamara, Howland, David, Loh, Dawn H, Wang, Huei-Bin, Whittaker, Daniel S   +5 more
core   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

A Biologically Plausible Architecture of the Striatum to Solve Context-Dependent Reinforcement Learning Tasks

Frontiers in Neural Circuits, 2017
Basal ganglia circuit is an important subcortical system of the brain thought to be responsible for reward-based learning. Striatum, the largest nucleus of the basal ganglia, serves as an input port that maps cortical information. Microanatomical studies
Sabyasachi Shivkumar, Vignesh Muralidharan, V. Srinivasa Chakravarthy   +2 more
doaj   +1 more source

Stress-induced reduction of dorsal striatal D2 dopamine receptors prevents retention of a newly acquired adaptive coping strategy [PDF]

, 2017
The inability to learn an adaptive coping strategy in a novel stressful condition leads to dysfunctional stress coping, a marker of mental disturbances.
Cabib, Simona, Campus, Paolo, Canterini, Sonia, Fiorenza, Maria Teresa, Orsini, Cristina, PUGLISI ALLEGRA, Stefano   +5 more
core   +1 more source

Discovery and Targeted Proteomic Studies Reveal Striatal Markers Validated for Huntington's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Clinical trials for Huntington's disease (HD) enrolling persons before clinical motor diagnosis (CMD) lack validated biomarkers. This study aimed to conduct an unbiased discovery analysis and a targeted examination of proteomic biomarkers scrutinized by clinical validation. Methods Cerebrospinal fluid was obtained from PREDICT‐HD and
Daniel Chelsky, Cara Joyce, H. Jeremy Bockholt, Paul A. Rudnick, William H. Adams, Fiona McAllister, Justin W. Smock, Michael A. Newton, Jane S. Paulsen   +8 more
wiley   +1 more source