Results 41 to 50 of about 178,790 (312)

Dopamine restores reward prediction errors in old age [PDF]

, 2013
Senescence affects the ability to utilize information about the likelihood of rewards for optimal decision-making. Using functional magnetic resonance imaging in humans, we found that healthy older adults had an abnormal signature of expected value ...
Dayan, P., Dolan, Raymond J, Dayan, P, Dolan, R., Huys, Q., Guitart-Masip, M. ; https://orcid.org/, Düzel, E., Rumana Chowdhury, Chowdhury, R., Christian Lambert, Emrah Düzel, Duezel, Emrah, Guitart-Masip, M., Dolan, Raymond J., Lambert, C., Lambert, C, Chowdhury, Rumana, Chowdhury, R, Guitart-Masip, Marc,, Guitart-Masip, Marc, Dolan, RJ, Marc Guitart-masip, Düzel, E, Dolan, R. ; https://orcid.org/, Raymond J Dolan, Peter Dayan, Dayan, Peter, Guitart-Masip, M, Düzel, Emrah, Huys, Q, Lambert, Christian, Quentin Huys, Huys, Quentin   +32 more
core   +1 more source

Neuronal Replacement as a Tool for Basal Ganglia Circuitry Repair: 40 Years in Perspective

Frontiers in Cellular Neuroscience, 2020
The ability of new neurons to promote repair of brain circuitry depends on their capacity to re-establish afferent and efferent connections with the host.
Anders Björklund, Malin Parmar
doaj   +1 more source

Maladaptive bias for extrahippocampal navigation strategies in aging humans. [PDF]

, 2013
Efficient spatial navigation requires not only accurate spatial knowledge but also the selection of appropriate strategies. Using a novel paradigm that allowed us to distinguish between beacon, associative cue, and place strategies, we investigated the ...
Wiener, Jan M., Wolbers, Thomas, Wiener, J.M., Harris, Mat, Harris, M. A., Wiener, J. M., Harris, M.A., de Condappa, O., de Condappa, Olivier, Wolbers, T.   +9 more
core   +1 more source

Adult-specific Reelin expression alters striatal neuronal organization: implications for neuropsychiatric disorders

Frontiers in Cellular Neuroscience, 2023
In addition to neuronal migration, brain development, and adult plasticity, the extracellular matrix protein Reelin has been extensively implicated in human psychiatric disorders such as schizophrenia, bipolar disorder, and autism spectrum disorder ...
Mònica Pardo, Mònica Pardo, Sara Gregorio, Sara Gregorio, Enrica Montalban, Lluís Pujadas, Lluís Pujadas, Lluís Pujadas, Lluís Pujadas, Alba Elias-Tersa, Alba Elias-Tersa, Núria Masachs, Núria Masachs, Alba Vílchez-Acosta, Alba Vílchez-Acosta, Annabelle Parent, Carme Auladell, Carme Auladell, Jean-Antoine Girault, Miquel Vila, Miquel Vila, Miquel Vila, Miquel Vila, Miquel Vila, Angus C. Nairn, Yasmina Manso, Yasmina Manso, Eduardo Soriano, Eduardo Soriano   +28 more
doaj   +1 more source

A new functional role for lateral inhibition in the striatum: Pavlovian conditioning

, 2011
The striatum has long been implicated in reinforcement learning and has been suggested by several neurophysiological studies as the substrate for encoding the reward value of stimuli.
Patrick Connor, Thomas Trappenberg
core   +1 more source

In vivo PET quantification of the dopamine transporter in rat brain with [¹⁸F]LBT-999. [PDF]

, 2013
INTRODUCTION: We examined whether [(18)F]LBT-999 ((E)-N-(4-fluorobut-2-enyl)2β-carbomethoxy-3β-(4'-tolyl)nortropane) is an efficient positron emission tomography (PET) tracer for the quantification of the dopamine transporter (DAT) in the healthy rat ...
Sérrière, Sophie, Tauber, Clovis, Chalon, Sylvie, Vercouillie, Johnny, Garreau, Lucette, Guilloteau, Denis, Galineau, Laurant, Deloye, Jean-Bernard   +7 more
core   +1 more source

Neural Correlates for Intrinsic Motivational Deficits of Schizophrenia; Implications for Therapeutics of Cognitive Impairment

Frontiers in Psychiatry, 2018
The ultimate goal of the treatment of schizophrenia is recovery, a notion related to improvement of cognitive and social functioning. Cognitive remediation therapies (CRT), one of the most effective cognition enhancing methods, have been shown to ...
Kazuyoshi Takeda, Tomiki Sumiyoshi, Madoka Matsumoto, Kou Murayama, Kou Murayama, Satoru Ikezawa, Kenji Matsumoto, Kazuyuki Nakagome   +7 more
doaj   +1 more source

GABA Neuronal Deletion of Shank3 Exons 14–16 in Mice Suppresses Striatal Excitatory Synaptic Input and Induces Social and Locomotor Abnormalities

Frontiers in Cellular Neuroscience, 2018
Shank3 is an excitatory postsynaptic scaffolding protein implicated in multiple brain disorders, including autism spectrum disorders (ASD) and Phelan-McDermid syndrome (PMS). Although previous neurobiological studies on Shank3 and Shank3-mutant mice have
Taesun Yoo, Heejin Cho, Jiseok Lee, Haram Park, Ye-Eun Yoo, Esther Yang, Jin Yong Kim, Hyun Kim, Eunjoon Kim, Eunjoon Kim   +9 more
doaj   +1 more source

Striatal dopamine transmission is subtly modified in human A53Tα-synuclein overexpressing mice

, 2012
Mutations in, or elevated dosage of, SNCA, the gene for α-synuclein (α-syn), cause familial Parkinson's disease (PD). Mouse lines overexpressing the mutant human A53Tα-syn may represent a model of early PD.
Auburger, G, Gispert, Suzana, Stephanie J Cragg, Suzana Gispert, Auburger Georg, Cragg, Stephanie J., Cragg Stephanie J., Georg Auburger, Gispert, S, Platt Nicola J., Auburger, Georg, Platt, NJ, Cragg, Stephanie, Nicola J Platt, Gispert Suzana, Platt, Nicola J.   +15 more
core   +1 more source

Ramping activity in the striatum

Frontiers in Computational Neuroscience, 2022
Control of the timing of behavior is thought to require the basal ganglia (BG) and BG pathologies impair performance in timing tasks. Temporal interval discrimination depends on the ramping activity of medium spiny neurons (MSN) in the main BG input structure, the striatum, but the underlying mechanisms driving this activity are unclear.
Adam Ponzi, Jeff Wickens
openaire   +4 more sources