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NP [PDF]

open access: yes, 2023
462.A.1.10(2).pdf created from original election material in the South African Elections Collection held in the Manuscripts Section of the Stellenbosch Library and Information Service.Campaign poster by the National Party (NP) encouraging South Africans ...

core  

CREB is a key regulator of striatal vulnerability in chemical and genetic models of Huntington's disease

open access: yesNeurobiology of Disease, 2009
Evidence of dysregulation of the CREB/CRE transcriptional pathway in animal models of Huntington's disease (HD) suggests that strategies designed to augment CRE-mediated transcription may be of therapeutic value. Here, we investigated the consequences of
Yun-Sik Choi   +7 more
doaj   +1 more source

Aquaporin-3 Attenuates Oxidative Stress-Induced Nucleus Pulposus Cell Apoptosis Through Regulating the P38 MAPK Pathway

open access: yesCellular Physiology and Biochemistry, 2018
Background/Aims: Previous studies have shown that oxidative damage is a main contributor to disc nucleus pulposus (NP) cell apoptosis. Aquaporin-3 (AQP-3) facilitates reactive oxygen species (ROS) scavenging and thus alleviates oxidative injury in other ...
Yichun Xu   +7 more
doaj   +1 more source

HMGB1 Promotes Mitochondrial Dysfunction-Triggered Striatal Neurodegeneration via Autophagy and Apoptosis Activation. [PDF]

open access: yesPLoS ONE, 2015
Impairments in mitochondrial energy metabolism are thought to be involved in many neurodegenerative diseases. The mitochondrial inhibitor 3-nitropropionic acid (3-NP) induces striatal pathology mimicking neurodegeneration in vivo. Previous studies showed
Lin Qi   +19 more
doaj   +1 more source

Erythropoietin and sonic hedgehog mediate the neuroprotective effects of brain-derived neurotrophic factor against mitochondrial inhibition

open access: yesNeurobiology of Disease, 2010
Brain-derived neurotrophic factor (BDNF) deficiency and mitochondrial dysfunction have been implicated in the pathogenesis of Huntington's disease (HD).
Chia-Lin Wu   +4 more
doaj   +1 more source

Microglial activation and cell death induced by the mitochondrial toxin 3-nitropropionic acid: in vitro and in vivo studies

open access: yesNeurobiology of Disease, 2003
Metabolic impairment of neurons has been implicated in several neurological disorders, but it is not at present known whether such metabolic impairment has deleterious effects on microglia, the phagocytic cells of the central nervous system (CNS). In the
Jae K Ryu   +5 more
doaj   +1 more source

Turkish Propolis and Its Nano Form Can Ameliorate the Side Effects of Cisplatin, Which Is a Widely Used Drug in the Treatment of Cancer

open access: yesPlants, 2020
This study was performed to determine the effects of chitosan-coated nano-propolis (NP), which is synthesized via a green sonochemical method, and propolis on the side effects of cisplatin (CP), which is a widely used drug in the treatment of cancer. For
Pinar Tatli Seven   +6 more
doaj   +1 more source

Determining PR8-NP-intNL mRNA splicing rates and virus stability in cell culture.

open access: yes, 2021
(A) Top: Diagram of “NP-int/NP” (yellow) and “NP-int only” (green) dye-based qPCR primer locations on PR8 NP-intNL mRNAs. Bottom, left: Absolute standard curve detecting “NP-int/NP” and “NP-int only” sequences from a plasmid containing an PR8 NP intron ...
Kaitlyn N. Burke (10885460)   +6 more
core   +1 more source

A Comparative Assessment of Nanotoxicity Induced by Metal (Silver, Nickel) and Metal Oxide (Cobalt, Chromium) Nanoparticles in Labeo rohita

open access: yesNanomaterials, 2019
In the present in vivo study, we provide a comparison of toxicological consequences induced by four different types of spherical nanoparticles (NPs)—silver nanoparticles (AgNPs, 40 ± 6 nm), nickel (NiNPs, 43 ± 6 nm), cobalt oxide ...
Zakia Kanwal   +6 more
doaj   +1 more source

Nutritional programming improves dietary plant protein utilization in zebrafish Danio rerio.

open access: yesPLoS ONE, 2020
Nutritional Programming (NP) has been shown to counteract the negative effects of dietary plant protein (PP) by introducing PP at an early age towards enhancement of PP utilization during later life stages.
Karolina Kwasek   +5 more
doaj   +1 more source

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