Results 291 to 300 of about 19,374,224 (331)

Piperine Enhances the Protective Effect of Curcumin Against 3-NP Induced Neurotoxicity: Possible Neurotransmitters Modulation Mechanism

Neurochemical Research, 2015
3-Nitropropionic acid (3-NP) is a fungal toxin well established model used for inducing symptoms of Huntington's disease. Curcumin a natural polyphenol has been reported to possess neuroprotective activity by decreasing oxidative stress. The aim of present study was to investigate neuroprotective effect of curcumin with piperine (bioavailability ...
Shamsher, Singh, Sumit, Jamwal, Puneet, Kumar   +2 more
openaire   +3 more sources

Preferential interneuron survival in the transition zone of 3‐NP‐induced striatal injury in rats

Journal of Neuroscience Research, 2011
AbstractHistology, immunohistochemistry, and Western blotting were used to characterize the changes in morphology, distribution pattern, and marker protein expression of striatal interneurons in the transition zone of striatal injury induced by 3‐NP. The 3‐NP treatment in rats yielded movement, motor coordination, and cognitive dysfunction.
Shuhua, Mu, Lisi, OuYang, Bingbing, Liu, Yaxi, Zhu, Keyi, Li, Mali, Zhan, Zongwei, Liu, Yu, Jia, Wanlong, Lei, A, Reiner   +9 more
openaire   +3 more sources

Spermidine ameliorates 3-nitropropionic acid (3-NP)-induced striatal toxicity: Possible role of oxidative stress, neuroinflammation, and neurotransmitters

Physiology & Behavior, 2016
Spermidine, a naturally occurring polyamine, is involved in various internal biological functions, due to its antioxidant and anti-inflammatory properties. A decreased level of polyamines is associated with aging and neurodegenerative disorders including Huntington disease (HD).
Sumit Jamwal, Puneet Kumar
openaire   +3 more sources

NGF attenuates 3-nitrotyrosine formation in a 3-NP model of Huntingtonʼs disease

NeuroReport, 1996
Nerve growth factor (NGF)-secreting fibroblasts are able to protect against the Huntington-like striatal neurodegeneration induced by the mitochondrial toxin 3-nitropropionic acid (3-NP). In the present study, we investigated whether the neuroprotective effects of NGF are mediated through antioxidative mechanisms.
Galpern, Wendy R., Matthews, Russell T., Beal, M. Flint, Isacson, Ole   +3 more
openaire   +4 more sources

Study on the aerobic biodegradability and degradation kinetics of 3-NP; 2,4-DNP and 2,6-DNP

Journal of Hazardous Materials, 2012
Four biodegradability tests (BOD(5)/COD ratio, production of carbon dioxide, relative oxygen uptake rate and relative enzymatic activity) were used to determine the aerobic biodegradability of 3-nitrophenol (3-NP), 2,4-dinitrophenol (2,4-DNP) and 2,6-dinitrophenol (2,6-DNP).
Zonglian, She, Tian, Xie, Yingjie, Zhu, Leilei, Li, Gaifeng, Tang, Jian, Huang   +5 more
openaire   +3 more sources

Cystamine and cysteamine prevent 3‐NP‐induced mitochondrial depolarization of Huntington's disease knock‐in striatal cells

European Journal of Neuroscience, 2006
AbstractCystamine significantly improved motor deficits and extended survival in mouse models of Huntington's disease (HD); however, the precise mechanism(s) by which cystamine and the related compound cysteamine are beneficial remain to be elucidated.
Zhengkuan, Mao, Yeun Su, Choo, Mathieu, Lesort   +2 more
openaire   +3 more sources

Neuroprotective effect of nicotine against 3-nitropropionic acid (3-NP)-induced experimental Huntington's disease in rats

Brain Research Bulletin, 2005
Nicotinic acetylcholine receptors (nAChRs) are regarded as potential therapeutic targets to control various neurodegenerative diseases. Owing to the relevance of cholinergic neurotransmission in the pathogenesis of Huntington's disease (HD) this investigation was aimed to study the effect of nicotine, a nAChR agonist, on 3-nitropropionic acid (3-NP ...
Mohammad, Tariq, Haseeb Ahmad, Khan, Ibrahim, Elfaki, Saleh, Al Deeb, Khalaf, Al Moutaery   +4 more
openaire   +3 more sources

Protective effect of minocycline, a semi-synthetic second-generation tetracycline against 3-nitropropionic acid (3-NP)-induced neurotoxicity

Toxicology, 2008
3-Nitropropionic acid (3-NP) is an irreversible inhibitor of the electron transport enzyme succinate dehydrogenase, a mitochondrial Complex II enzyme. Minocycline is a semi-synthetic second-generation tetracycline with neuroprotective activity and has the capability to effectively cross the blood-brain barrier.
Manuj, Ahuja, Mahendra, Bishnoi, Kanwaljit, Chopra   +2 more
openaire   +3 more sources

L-theanine, a Component of Green Tea Prevents 3-Nitropropionic Acid (3-NP)-Induced Striatal Toxicity by Modulating Nitric Oxide Pathway

Molecular Neurobiology, 2016
L-theanine is unique amino acid which readily crosses blood brain barrier and possesses neuroprotective potential against neurodegenerative disorders including Huntington disease (HD). HD is characterized by selective loss of GABAergic medium spiny neurons.
Sumit, Jamwal, Puneet, Kumar
openaire   +3 more sources

Succinobucol versus probucol: Higher efficiency of succinobucol in mitigating 3-NP-induced brain mitochondrial dysfunction and oxidative stress in vitro

Mitochondrion, 2013
This study evaluated and compared the potential protective effects of probucol and succinobucol, two lipid-lowering compounds with anti-inflammatory and antioxidant properties, on oxidative stress and mitochondrial dysfunction induced by 3-nitropropionic acid (3-NP, a succinate dehydrogenase (SDH) inhibitor largely used as model of Huntington's disease)
Dirleise, Colle, Danúbia B, Santos, Juliana M, Hartwig, Marcelo, Godoi, Antonio L, Braga, Marcelo, Farina   +5 more
openaire   +3 more sources