Results 81 to 90 of about 17,169,589 (293)

Complement Receptor 3 Pathway and NMDA Receptor 2B Subunit Involve Neuropathic Pain Associated with Spinal Cord Injury

Journal of Pain Research, 2022
Yong Li,1,* Sheng-Chun Fang,2,* Lan Zhou,1 Xue-Mei Mo,3 Hao-Dong Guo,3 Yan-Bo Deng,3 Hong-Hao Yu,1 Wei-Yi Gong3 1College of Biotechnology, Guilin Medical University, Guilin, Guangxi, 541100, People’s Republic of China; 2Department of ...
Li Y, Fang SC, Zhou L, Mo XM, Guo HD, Deng YB, Yu HH, Gong WY   +7 more
doaj  

More Insight into BDNF against Neurodegeneration: Anti-Apoptosis, Anti-Oxidation, and Suppression of Autophagy

International Journal of Molecular Sciences, 2017
In addition to its well-established neurotrophic action, brain-derived neurotrophic factor (BDNF) also possesses other neuroprotective effects including anti-apoptosis, anti-oxidation, and suppression of autophagy. We have shown before that BDNF triggers
Shang-Der Chen, Chia-Lin Wu, Wei‐Chao Hwang, Ding-I Yang   +3 more
semanticscholar   +1 more source

Interacting multi-component exciton gases in a potential trap: phase separation and Bose-Einstein condensation

, 2010
The system under consideration is a multi-component gas of interacting para- and orthoexcitons confined in a three dimensional potential trap. We calculate the spatially resolved optical emission spectrum due to interband transitions involving weak ...
D. Semkat, H. Fehske, H. Stolz, L. Pitaevskii, S. Sobkowiak, Th. Koch   +5 more
core   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Probucol increases striatal glutathione peroxidase activity and protects against 3-nitropropionic acid-induced pro-oxidative damage in rats. [PDF]

PLoS ONE, 2013
Huntington's disease (HD) is an autosomal dominantly inherited neurodegenerative disease characterized by symptoms attributable to the death of striatal and cortical neurons.
Dirleise Colle, Danúbia Bonfanti Santos, Eduardo Luiz Gasnhar Moreira, Juliana Montagna Hartwig, Alessandra Antunes dos Santos, Luciana Teixeira Zimmermann, Mariana Appel Hort, Marcelo Farina   +7 more
doaj   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source

Chitosan-titanium oxide fibers supported zero-valent nanoparticles: Highly efficient and easily retrievable catalyst for the removal of organic pollutants

Scientific Reports, 2018
Different chitosan-titanium oxide (CS-TiO2-x, with x = TiO2 loadings of 1, 5, 10,15 and 20 wt%) nanocomposite fibers were prepared and kept separately in each salt solution of CuSO4, CoNO3, AgNO3 and NiSO4 to adsorb Cu2+, Co2+, Ag+, and Ni+ ions ...
F. Ali, S. B. Khan, T. Kamal, K. Alamry, Abdullah M. Asiri   +4 more
semanticscholar   +1 more source

Studies of concentration and temperature dependencies of precipitation kinetics in iron-copper alloys using kinetic monte carlo and stochastic statistical simulations

, 2012
The earlier-developed ab initio model and the kinetic Monte Carlo method (KMCM) are used to simulate precipitation in a number of iron-copper alloys with different copper concentrations x and temperatures T.
A V Barashev, A Yu Stroev, C Wagner, F Soisson, F Soisson, F Soisson, F Soisson, F Soisson, I M Lifshitz, I. A. Zhuravlev, K Yu Khromov, K. Yu. Khromov, M H Mathon, M K Miller, M Nastar, R P Kolli, R P Kolli, R Shabadi, S R Goodman, V G Vaks, V G Vaks, V G Vaks, V Yu Dobretsov, V. G. Vaks   +23 more
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Utilizing targeted gene therapy with nanoparticles binding alpha v beta 3 for imaging and treating choroidal neovascularization.

PLoS ONE, 2011
PurposeThe integrin αvβ3 is differentially expressed on neovascular endothelial cells. We investigated whether a novel intravenously injectable αvβ3 integrin-ligand coupled nanoparticle (NP) can target choroidal neovascular membranes (CNV) for imaging ...
Hani Salehi-Had, Mi In Roh, Andrea Giani, Toshio Hisatomi, Shintaro Nakao, Ivana K Kim, Evangelos S Gragoudas, Demetrios Vavvas, Samira Guccione, Joan W Miller   +9 more
doaj   +1 more source