Results 81 to 90 of about 19,351,043 (289)

Probucol increases striatal glutathione peroxidase activity and protects against 3-nitropropionic acid-induced pro-oxidative damage in rats. [PDF]

PLoS ONE, 2013
Huntington's disease (HD) is an autosomal dominantly inherited neurodegenerative disease characterized by symptoms attributable to the death of striatal and cortical neurons.
Dirleise Colle, Danúbia Bonfanti Santos, Eduardo Luiz Gasnhar Moreira, Juliana Montagna Hartwig, Alessandra Antunes dos Santos, Luciana Teixeira Zimmermann, Mariana Appel Hort, Marcelo Farina   +7 more
doaj   +1 more source

Chameleon sequences reveal structural effects in proteins representing micelle‐like distribution of hydrophobicity

FEBS Open Bio, EarlyView.
Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman, Katarzyna Stapor, Leszek Konieczny, Krzysztof Gądek, Piotr Nowakowski   +4 more
wiley   +1 more source

Interacting multi-component exciton gases in a potential trap: phase separation and Bose-Einstein condensation

, 2010
The system under consideration is a multi-component gas of interacting para- and orthoexcitons confined in a three dimensional potential trap. We calculate the spatially resolved optical emission spectrum due to interband transitions involving weak ...
D. Semkat, H. Fehske, H. Stolz, L. Pitaevskii, S. Sobkowiak, Th. Koch   +5 more
core   +1 more source

Iron homeostasis disruption and lipid peroxidation in skeletal muscle during short‐term immobilization

FEBS Open Bio, EarlyView.
14‐day casting‐induced immobilization reduced gastrocnemius muscle mass and increased non‐heme iron and ferritin heavy chain levels. Despite iron accumulation, transferrin receptor 1 and iron regulatory protein 2 were paradoxically upregulated. Lipid peroxidation was elevated without compensatory antioxidant responses.
Haruka Yokogawa, Kazuhiko Higashida, Naoya Nakai   +2 more
wiley   +1 more source

Utilizing targeted gene therapy with nanoparticles binding alpha v beta 3 for imaging and treating choroidal neovascularization.

PLoS ONE, 2011
PurposeThe integrin αvβ3 is differentially expressed on neovascular endothelial cells. We investigated whether a novel intravenously injectable αvβ3 integrin-ligand coupled nanoparticle (NP) can target choroidal neovascular membranes (CNV) for imaging ...
Hani Salehi-Had, Mi In Roh, Andrea Giani, Toshio Hisatomi, Shintaro Nakao, Ivana K Kim, Evangelos S Gragoudas, Demetrios Vavvas, Samira Guccione, Joan W Miller   +9 more
doaj   +1 more source

Roman spa - sauna world [PDF]

, 2013
Diplomová práce byla vypracována jako návrh interiéru Římských lázní a saunového světa. Římské lázně a saunový svět se nachází ve 3.NP objektu Aquacentra, jehož návrh byl zpracován ve Specializovaném ateliéru ve 2.
Vičánková, Lenka
core  

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Proactive transplantation of human neural stem cells prevents degeneration of striatal neurons in a rat model of Huntington disease

Neurobiology of Disease, 2004
We have investigated the effectiveness of transplantation of human neural stem cells into adult rat striatum prior to induction of striatal damage with the mitochondrial toxin 3-nitropropionic acid (3-NP).
Jae K Ryu, Jean Kim, Sung J Cho, Kozo Hatori, Astushi Nagai, Hyun B Choi, Min C Lee, James G McLarnon, Seung U Kim   +8 more
doaj   +1 more source

Mice Deficient in Cellular Glutathione Peroxidase Show Increased Vulnerability to Malonate, 3-Nitropropionic Acid, and 1-Methyl-4-Phenyl-1,2,5,6-Tetrahydropyridine

Journal of Neuroscience, 2000
Glutathione peroxidase (GSHPx) is a critical intracellular enzyme involved in detoxification of hydrogen peroxide (H2O2) to water. In the present study we examined the susceptibility of mice with a disruption of the glutathione peroxidase gene to the ...
P. Klivényi, Ole A. Andreassen, R. Ferrante, A. Dedeoglu, Gerald Mueller, E. Lancelot, M. Bogdanov, Julie K. Andersen, D. Jiang, M. Beal   +9 more
semanticscholar   +1 more source

Normal type-2 Fuzzy Rational B-Spline Curve

, 2013
In this paper, we proposed a new form of type-2 fuzzy data points(T2FDPs) that is normal type-2 data points(NT2FDPs). These brand-new forms of data were defined by using the definition of normal type-2 triangular fuzzy number(NT2TFN).
Gobithaasan, R. U., Wahab, Abd. Fatah, Zakaria, Rozaimi   +2 more
core   +1 more source