Results 71 to 80 of about 13,770,514 (290)

3-NP-induced Huntington's-like disease impairs Nrf2 activation without loss of cardiac function in aged rats

Experimental Gerontology, 2017
Cardiovascular diseases (CVDs) are one of the leading causes of death in patients over 60years with Huntington's disease (HD). Here, we investigated if age-related oxidative stress (OS) is a relevant factor to develop cardiac damage in an in vivo model of striatal neurodegeneration induced by 3-nitropropionic acid (3-NP).
A, Silva-Palacios, M, Ostolga-Chavarría, M, Buelna-Chontal, C, Garibay, S, Hernández-Reséndiz, F J, Roldán, P L, Flores, A, Luna-López, M, Königsberg, C, Zazueta   +9 more
openaire   +2 more sources

Role of surface charge and oxidative stress in cytotoxicity of organic monolayer-coated silicon nanoparticles towards macrophage NR8383 cells

Particle and Fibre Toxicology, 2010
Background Surface charge and oxidative stress are often hypothesized to be important factors in cytotoxicity of nanoparticles. However, the role of these factors is not well understood.
Bhattacharjee Sourav, de Haan Laura HJ, Evers Nynke M, Jiang Xue, Marcelis Antonius TM, Zuilhof Han, Rietjens Ivonne MCM, Alink Gerrit M   +7 more
doaj   +1 more source

k-L(2, 1)-labelling for planar graphs is NP-complete for k>=4

, 2009
A mapping from the vertex set of a graph G=(V,E) into an interval of integers {0,...,k} is an L(2,1)-labelling of G of span k if any two adjacent vertices are mapped onto integers that are at least 2 apart, and every two vertices with a common ...
Noble, Steven, Havet, F, Eggemann, N, Havet, F., Nicole Eggemann, Frédéric Havet, Eggemann, N., Noble, S D, Steven D. Noble   +8 more
core   +1 more source

Complexity results for the gap inequalities for the max-cut problem [PDF]

, 2012
We prove several complexity results about the gap inequalities for the max-cut problem, including (i) the gap-1 inequalities do not imply the other gap inequalities, unless NP=Co NP; (ii) there must exist non-redundant gap inequalities with exponentially
Galli, Laura, Letchford, Adam, Kaparis, Konstantinos, Letchford, A N   +3 more
core   +1 more source

Photomicrograph of the striatum of 3-NP-ijnected group showing nuclear pyknosis of the degenerated neurons (white arrow) with gliosis satellatosis (green arrow) and neuronophagia (H&E 400x & 1000x).

, 2023
Photomicrograph of the striatum of 3-NP-ijnected group showing nuclear pyknosis of the degenerated neurons (white arrow) with gliosis satellatosis (green arrow) and neuronophagia (H&E 400x & 1000x).
Roqaya Mahmoud Hussein (17319695), Sherine Maher Rizk (17319698), Nagwa Ibrahim Shehata (17319689), Dina Mohamed Abd EL-Salam (17319692)   +3 more
core   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Complement Receptor 3 Pathway and NMDA Receptor 2B Subunit Involve Neuropathic Pain Associated with Spinal Cord Injury

Journal of Pain Research, 2022
Yong Li,1,* Sheng-Chun Fang,2,* Lan Zhou,1 Xue-Mei Mo,3 Hao-Dong Guo,3 Yan-Bo Deng,3 Hong-Hao Yu,1 Wei-Yi Gong3 1College of Biotechnology, Guilin Medical University, Guilin, Guangxi, 541100, People’s Republic of China; 2Department of ...
Li Y, Fang SC, Zhou L, Mo XM, Guo HD, Deng YB, Yu HH, Gong WY   +7 more
doaj  

Optical waveguide amplifiers based on NaYF_4: Er^3+, Yb^3+ NPs-PMMA covalent-linking nanocomposites

Optical Materials Express, 2015
NaYF4: Er3+, Yb3+ nanoparticles (NPs) were synthesized by using a high temperature thermal decomposition approach. Under a 980 nm laser excitation, intense emission at 1.53 μm from NaYF4: Er3+,Yb3+ NPs was obtained. NaYF4: Er3+, Yb3+ NPs-PMMA covalent-linking nanocomposite was prepared by copolymerization of the oleic acid-modified NaYF4: Er3+, Yb3 ...
Tianjiao Wang, Dan Zhao, Meiling Zhang, Jiao Yin, Weiye Song, Zhixu Jia, Xibin Wang, Guanshi Qin, Weiping Qin, Fei Wang, Daming Zhang   +10 more
openaire   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Probucol increases striatal glutathione peroxidase activity and protects against 3-nitropropionic acid-induced pro-oxidative damage in rats. [PDF]

PLoS ONE, 2013
Huntington's disease (HD) is an autosomal dominantly inherited neurodegenerative disease characterized by symptoms attributable to the death of striatal and cortical neurons.
Dirleise Colle, Danúbia Bonfanti Santos, Eduardo Luiz Gasnhar Moreira, Juliana Montagna Hartwig, Alessandra Antunes dos Santos, Luciana Teixeira Zimmermann, Mariana Appel Hort, Marcelo Farina   +7 more
doaj   +1 more source